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Home > Art, Film & Photography > EC 3.4.23: Pepsin
EC 3.4.23: Pepsin

EC 3.4.23: Pepsin


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Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Pepsin - Wikipedia, the free encyclopedia Pepsin is expressed as a pro-form zymogen, pepsinogen, whose primary structure has an additional 44 amino acids. In the stomach, chief cells release pepsinogen. This zymogen is activated by hydrochloric acid (HCl), which is released from parietal cells in the stomach lining. The hormone gastrin and the vagus nerve trigger the release of both pepsinogen and HCl from the stomach lining when food is ingested. Hydrochloric acid creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic fashion, thereby generating pepsin (the active form). Pepsin cleaves the 44 amino acids from pepsinogen to create more pepsin. Pepsin will digest up to 20% of ingested amide bonds by cleaving preferentially after the N-terminal of aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. Pepsin exhibits preferential cleavage for hydrophobic, preferably aromatic, residues in P1 and P1' positions. Increased susceptibility to hydrolysis occurs if there is a sulfur-containing amino acid close to the peptide bond, which has an aromatic amino acid. Pepsin cleaves PheVal, GlnHis, GluAla, AlaLeu, LeuTyr, TyrLeu, GlyPhe, PhePhe and PheTyr bonds in the B chain of insulin. Peptides may be further digested by other proteases (in the duodenum) and eventually absorbed by the body. Pepsin is stored as pepsinogen so it will only be released when needed, and does not digest the body's own proteins in the stomach's lining. Pepsin functions best in acidic environments and is often found in an acidic environment, in particular those with a pH of 1.5 to 2. Pepsin denatures if the pH is more than 5.0. Pepsin is said to have an optimum temperature between 37C and 42C in humans. Pepsin is p... More: http://booksllc.net/?id=169118


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Product Details
  • ISBN-13: 9781156258217
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Pepsin
  • Width: 229 mm
  • ISBN-10: 1156258219
  • Publisher Date: 31 May 2010
  • Binding: Paperback
  • Spine Width: 2 mm
  • Weight: 73 gr


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