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Home > Art, Film & Photography > Polyomaviruses: Merkel Cell Polyomavirus
Polyomaviruses: Merkel Cell Polyomavirus

Polyomaviruses: Merkel Cell Polyomavirus


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About the Book

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Merkel cell polyomavirus (MCV or MCPyV) was first described in January 2008. MCV is one of seven known human tumor viruses. It is suspected to cause the majority of cases of Merkel cell carcinoma, a rare but aggressive form of skin cancer. Approximately 80% of Merkel cell carcinoma (MCe tumors have been found to be infected with MCV. MCV appears to be a commonif not universalinfection of older children and adults. It is found in respiratory secretions suggesting that it may be transmitted by a respiratory route. Most MCV viruses found in MCC tumors, however, have at least two mutations that render the virus nontransmissible: 1) The virus is integrated into the host genome in a monoclonal fashion and 2) The viral T antigen has truncation mutations that leave the T antigen unable to initiate DNA replication needed to propagate the virus. Family tree of the polyomaviruses, based on large T antigen sequence Electron microphotograph (x50,000) of MCV capsids artificially produced as virus-like particles by expressing MCV structural proteins in cells. The 55-60 nm viral capsids have typical icosahedral symmetry found in polyomaviruses.Polyomaviruses are small (~5400 base pair), non-enveloped, double-stranded DNA viruses. MCV is the fifth polyomavirus that infects humans to be discovered. It belongs to the murine polyomavirus group, one of the three main clades of polyomaviruses. (The group is named for murine polyomavirus, the earliest virus of the group to be discovered, and does not imply that MCV is transmitted to humans from rodents.) MCV is the only human polyomavirus discovered to date that does not fall within the SV40-like clade. MCV is genetically most closely related to the African green monkey lymphotropic polyomavirus (formerly known ... More: http://booksllc.net/?id=16814276


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Product Details
  • ISBN-13: 9781156192351
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 40
  • Spine Width: 2 mm
  • Weight: 73 gr
  • ISBN-10: 1156192358
  • Publisher Date: 31 May 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Merkel Cell Polyomavirus
  • Width: 229 mm


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