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Opioid Receptor: Kappa Opioid Receptor

Opioid Receptor: Kappa Opioid Receptor


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About the Book

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: The -opioid receptor (KOR) is a type of opioid receptor which binds the opioid peptide dynorphin as the primary endogenous ligand. -Opioid receptors are widely distributed in the brain (hypothalamus, periaqueductal gray, and claustrum), spinal cord (substantia gelatinosa), and in pain neurons. Based on receptor binding studies, three variants of the -opioid receptor designated 1, 2, and 3 have been characterized. However only one cDNA clone has been identified, hence these receptor subtypes likely arise from interaction of one -opioid receptor protein with other membrane associated proteins. It has long been understood that -opioid receptor agonists are dysphoric but dysphoria from -opioid receptor agonists has been shown to differ between sexes More recent studies have shown the aversive properties in a variety of ways and the -opioid receptor has been strongly implicated as an integral neurochemical component of addiction and the remission thereof. It is now widely accepted that -opioid receptor (partial) agonists have dissociative and deliriant effects, as exemplified by salvinorin A. These effects are generally undesirable in medicinal drugs and could have had frightening or disturbing effects in the tested humans. It is thought that the hallucinogenic effects of drugs such as butorphanol, nalbuphine, and pentazocine serve to limit their opiate abuse potential. In the case of salvinorin A, a structurally novel neoclerodane diterpene -opioid receptor agonist, these hallucinogenic, more specifically deliriant and dissciative, effects are sought after, even though the substance is inherently dysphoric. While salvinorin A is considered a hallucinogen, it is not a psychedelic, and its effects are qualitatively different than those produced by... More: http://booksllc.net/?id=5203386


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Product Details
  • ISBN-13: 9781156188705
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Kappa Opioid Receptor
  • Width: 229 mm
  • ISBN-10: 1156188709
  • Publisher Date: 31 May 2010
  • Binding: Paperback
  • Spine Width: 3 mm
  • Weight: 73 gr


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