About the Book
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 36. Chapters: AH-1058, Amlodipine, Amlodipine/valsartan, Anipamil, Aranidipine, Azelnidipine, Azor (medication), Barnidipine, Bay K8644, Bencyclane, Benidipine, Bepridil, Berbamine, Calcium channel blocker, Canadine, Carboxyamidotriazole, Cilnidipine, Clentiazem, Clevidipine, Darodipine, Dauricine, Devapamil, Dihydropyridine, Diltiazem, Dimeditiapramine, Diproteverine, Dotarizine, Efonidipine, Emopamil, Enpiperate, Falipamil, Fantofarone, Felodipine, Fendiline, Flunarizine, Gallopamil, Isradipine, JTV-519, Lercanidipine, Lidoflazine, Manidipine, Manoalide, Mepirodipine, Mibefradil, Monatepil, Naftopidil, Nicardipine, Nifedipine, Niguldipine, Niludipin, Nilvadipine, Nimodipine, Nisoldipine, Nitrendipine, Norverapamil, Osthol, Oxodipine, Pinaverium, Pranidipine, Ryodipine, Sesamodil, Tetrandrine, TROX-1. Excerpt: Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is also an effective preventive medication for migraine. It is a class 3 antianginal drug, and a class IV antiarrhythmic. It is a common adulterant of cocaine seized in the UK, and has been found to reduce cocaine cravings in rats, indicating it may prolong the "high" (see below). It incites minimal reflex sympathetic changes. It is based upon a 1,4-thiazepine ring. Diltiazem is metabolized by and acts as an inhibitor of the CYP3A4 enzyme. 180mg Cardizem capsuleDiltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil. It is a potent vasodilator of coronary and peripheral vessels, which reduces peripheral resistance and afterload. Because of its negative inotropic effect, diltiazem causes a modest decrease in heart muscle contractility and reduces myocardium oxygen consumption. Its negative chronotropic effect results in a modest lowering of heart rate, due to slowing of the sinoatrial node. It results in reduced myocardium oxygen consumption. Because of its negative dromotropic effect, conduction through the AV (atrioventricular) node is slowed, which increases the time needed for each beat. This results in reduced myocardium oxygen consumption. A reflex sympathetic response, caused by the peripheral dilation of vessels and the resulting drop in BP, works to counteract the negative inotropic, chronotropic and dromotropic effects of diltiazem. Undesirable effects include hypotension, bradycardia, dizziness, and flushing. The drug is indicated for angina: For supraventricular tachycardias, diltiazem appears to be as effective as verapamil in treating re-entrant supraventricular tachycardia. Atrial fibrillation or atrial flutter PS
