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Home > Art, Film & Photography > Mice: Mouse, Mouse Models of Colorectal and Intestinal Cancer, Fancy Mouse, Mousetrap, Knockout Mouse, Balb-C, Oncomouse, Nod Mice, C57bl-6
Mice: Mouse, Mouse Models of Colorectal and Intestinal Cancer, Fancy Mouse, Mousetrap, Knockout Mouse, Balb-C, Oncomouse, Nod Mice, C57bl-6

Mice: Mouse, Mouse Models of Colorectal and Intestinal Cancer, Fancy Mouse, Mousetrap, Knockout Mouse, Balb-C, Oncomouse, Nod Mice, C57bl-6


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About the Book

Chapters: Mouse, Mouse Models of Colorectal and Intestinal Cancer, Fancy Mouse, Mousetrap, Knockout Mouse, Balb/c, Oncomouse, Nod Mice, C57bl/6, Vacanti Mouse, Ob/ob Mouse, Sticky Mouse, Scrambler Mouse, Tail Vein, Murphy Roths Large, Scid Mouse. Source: Wikipedia. Pages: 76. Not illustrated. Free updates online. Purchase includes a free trial membership in the publisher's book club where you can select from more than a million books without charge. Excerpt: Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated or challenged with chemicals to develop malignancies in the gastrointestinal tract. These models enable researchers to study the onset, progression of the disease, and understand in depth the molecular events that contribute to the development and spread of colorectal cancer. They also provide a valuable biological system, to simulate human physiological conditions, suitable for testing therapeutics that can potentially benefit patients. An important example is the development of the APC mutant mouse model of colorectal cancer and the subsequent observation that cyclooxygenase expression is an early event in colorectal carcinogenesis. Genetic disruption of the cyclooxygenase-2 (COX-2) gene or inhibition of the activity of COX-2 with chemical inhibitors reduced the polyp burden in mice. These observations gave rationale to treat human patients suffering from the familial form of the disease FAP with specific COX-2 inhibitors. FAP is a hereditary disease that is characterized with development of numerous colon polyps. A genetic analysis of some FAP kindreds revealed that a common feature of the disease is a deletion of the APC gene. Further analysis of the APC gene revealed the existence of various mutations in cancer sufferers that also play a role in the onset of the sporadic form of colorectal cancer. The first mouse mutant in the Apc gene came fr...More: http: //booksllc.net/?id=1681863


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Product Details
  • ISBN-13: 9781155711577
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 78
  • Spine Width: 5 mm
  • Weight: 127 gr
  • ISBN-10: 1155711572
  • Publisher Date: 15 Sep 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Mouse, Mouse Models of Colorectal and Intestinal Cancer, Fancy Mouse, Mousetrap, Knockout Mouse, Balb-C, Oncomouse, Nod Mice, C57bl-6
  • Width: 229 mm


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