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Home > Art, Film & Photography > Triptans: Triptans: Drug Discovery and Development, Sumatriptan, Triptan, Almotriptan, Eletriptan, Zolmitriptan, Naratriptan, Frovatriptan
Triptans: Triptans: Drug Discovery and Development, Sumatriptan, Triptan, Almotriptan, Eletriptan, Zolmitriptan, Naratriptan, Frovatriptan

Triptans: Triptans: Drug Discovery and Development, Sumatriptan, Triptan, Almotriptan, Eletriptan, Zolmitriptan, Naratriptan, Frovatriptan


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About the Book

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Triptans: Drug Discovery and Development, Sumatriptan, Triptan, Almotriptan, Eletriptan, Zolmitriptan, Naratriptan, Frovatriptan, Rizatriptan, Avitriptan. Excerpt: Almotriptan (trade names: Axert (US-Canada), Almogran (Belgium, Denmark, Finland, France, Germany, Italy, Ireland Portugal, Spain, the United Kingdom, the Netherlands, Sweden, Switzerland, South Korea ) ] also Almotrex (Italy) and Amignul (Spain)), is a triptan drug discovered and developed by Almirall for the treatment of migraine headache . It is available in 12.5 mg in most countries and also 6.25 mg in US and Canada. Indications Almotriptan is prescribed to treat the acute treatment of the headache phase of migraine attacks with or without aura . Almotriptan is the only oral triptan approved in the USA for the treatment of migraine in adolescent from 12 to 17 years of age. Mode of action Almotriptan is a selective and potent serotonin 5-HT1B/1D agonist . Because of the particular distribution of the 5-HT1B/1D receptors, almotriptan basically constricts the human meningeal arteries; therefore it has a limited effect on arteries supplying blood to the brain, and little effect on cardiac and pulmonary vessels. Pharmacokinetics Almotriptan has no clinically relevant pharmacokinetic drug interactions and is metabolized through different pathways, requiring no dosage adjustment in patients with non-severe renal or hepatic impairment. There are also no clinically relevant differences between men and women or between the young and the elderly. Efficacy The efficacy of almotriptan in the acute treatment of migraine attacks was established in clinical trials involving more than 3000 patients who were administered 12.5 mg and it was found to have a fast onset of action and high efficacy to reach pain free status (see re...


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Product Details
  • ISBN-13: 9781155655055
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Triptans: Drug Discovery and Development, Sumatriptan, Triptan, Almotriptan, Eletriptan, Zolmitriptan, Naratriptan, Frovatriptan
  • Width: 229 mm
  • ISBN-10: 1155655052
  • Publisher Date: 06 May 2010
  • Binding: Paperback
  • Spine Width: 3 mm
  • Weight: 95 gr


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