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Home > Art, Film & Photography > Inotropic Agents: Dopamine, Digoxin, Levosimendan, Isoprenaline, Inotrope, Dopexamine
Inotropic Agents: Dopamine, Digoxin, Levosimendan, Isoprenaline, Inotrope, Dopexamine

Inotropic Agents: Dopamine, Digoxin, Levosimendan, Isoprenaline, Inotrope, Dopexamine


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About the Book

Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Dopamine, Digoxin, Levosimendan, Isoprenaline, Inotrope, Dopexamine, Milrinone. Excerpt: Digoxin (INN ) (pronounced /d d ks n/ ), also known as digitalis, is a purified cardiac glycoside extracted from the foxglove plant, Digitalis lanata . Its corresponding aglycone is digoxigenin, and its acetyl derivative is acetyldigoxin . Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication . Digoxin preparations are commonly marketed under the trade names Lanoxin, Digitek, and Lanoxicaps . It is also available as a 0.05 mg/mL oral solution and 0.25 mg/mL or 0.5 mg/mL injectable solution. It is marketed by GlaxoSmithKline . Actions The main pharmacological effects of digoxin are on the heart . Extracardiac effects are responsible for many of the adverse effects (see below). It has mechanical effects as it increases myocardial contractility, however, the duration of the contractile response is just slightly increased. Overall, the heart rate is decreased, while blood pressure increases as the stroke volume is increased, leading to increased tissue perfusion . Myocardial efficiency improves due to improved hemodynamics, and the ventricular function curve is improved. Other, electrical effects are an initial brief increase in action potential, followed by a decrease as the K conductance increases due to an increased intracellular amounts of Ca ions. The refractory period of the atria and ventricles is decreased, while it increases in the sinoatrial and AV nodes. Less negative RMP is made, leading to increased excitability. Other, more indirect effects are cholinomimetic because of vagal stimulation, giving rise to AV nodal delay. The conduction velocity ...


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Product Details
  • ISBN-13: 9781155533575
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • Sub Title: Dopamine, Digoxin, Levosimendan, Isoprenaline, Inotrope, Dopexamine
  • Width: 229 mm
  • ISBN-10: 1155533577
  • Publisher Date: 04 May 2010
  • Binding: Paperback
  • Spine Width: 3 mm
  • Weight: 91 gr


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