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Home > Art, Film & Photography > Statins: Statin, Simvastatin, Atorvastatin, Lovastatin, Mevalonate Inhibition, Cholesterol Depletion, Rosuvastatin, Ezetimibe]simvastatin
Statins: Statin, Simvastatin, Atorvastatin, Lovastatin, Mevalonate Inhibition, Cholesterol Depletion, Rosuvastatin, Ezetimibe]simvastatin

Statins: Statin, Simvastatin, Atorvastatin, Lovastatin, Mevalonate Inhibition, Cholesterol Depletion, Rosuvastatin, Ezetimibe]simvastatin


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Purchase includes free access to book updates online and a free trial membership in the publisher's book club where you can select from more than a million books without charge. Chapters: Statin, Simvastatin, Atorvastatin, Lovastatin, Mevalonate Inhibition, Cholesterol Depletion, Rosuvastatin, Ezetimibe/simvastatin, Cerivastatin, Pitavastatin, Pravastatin, Scandinavian Simvastatin Survival Study, Caduet, Mevastatin, Fluvastatin. Excerpt: Atorvastatin (INN ) (pronounced / t rv st]t n/ ) ( Lipitor, Pfizer), is a member of the drug class known as statins, used for lowering blood cholesterol . It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Atorvastatin inhibits HMG-CoA reductase, the rate-determining enzyme located in hepatic tissue that produces mevalonate, a small molecule used in the synthesis of cholesterol and other mevalonate derivatives. This lowers the amount of cholesterol produced which in turn lowers the total amount of LDL cholesterol . Atorvastatin was first synthesized in 1985 by Bruce Roth while working at Parke-Davis Warner-Lambert Company (now Pfizer ). With 2008 sales of US $12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world. US patent protection is scheduled to expire in June 2011. However, Pfizer made an agreement with Ranbaxy Laboratories to delay the generic launch in the US until November 2011. Atorvastatin is one of many statins on the market. Pharmacology Main article: Statin As with other statins, atorvastatin is a competitive inhibitor of HMG-CoA reductase . Unlike most others, however, it is a completely synthetic compound. HMG-CoA reductase catalyzes the reduction of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) to mevalonate, which is the rate-limiting step in hepatic cholesterol biosynthesis. Inhibition of the enzyme decreases de novo cholesterol synthesis, increasing expression of low-density lipoprotein receptors (LDL receptors ) on hepatocytes . This i...


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Product Details
  • ISBN-13: 9781155282633
  • Publisher: Books LLC
  • Publisher Imprint: Books LLC
  • Height: 152 mm
  • No of Pages: 94
  • Spine Width: 6 mm
  • Weight: 150 gr
  • ISBN-10: 1155282639
  • Publisher Date: 02 May 2010
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Sub Title: Statin, Simvastatin, Atorvastatin, Lovastatin, Mevalonate Inhibition, Cholesterol Depletion, Rosuvastatin, Ezetimibe]simvastatin
  • Width: 229 mm


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