Methodologies for Metabolomics
Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Methodologies for Metabolomics: Experimental Strategies and Techniques
29%
Methodologies for Metabolomics: Experimental Strategies and Techniques

Methodologies for Metabolomics: Experimental Strategies and Techniques


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Table of Contents:
List of contributors; Part I. Basic Methodological Strategies in Metabolomic Research: 1. Exploring the human metabolome by nuclear magnetic resonance spectroscopy and mass spectroscopy; 2. Methodological requirements for lipidomics research; 3. Biological methods for metabolic research; Part II. Metabolomic Mass Spectrometry: Experimental Techniques and Bioinformatics: 4. Considerations in sample preparation, collection, and extraction approaches applied in microbial, plant, and mammalian metabolic profiling; 5. Mass spectrometry-based methodologies for single-cell metabolite detection and identification; 6. Direct metabolomics from tissues and cells: laser ablation electrospray ionization for small molecule and lipid characterization; 7. Bioinformatic approaches to processing and annotation of high-resolution mass spectrometry data; 8. Approaches for natural product detection and structural elucidation using mass spectrometry with high mass accuracy; 9. Metabolomics using ion mobility mass spectrometry; 10. Metabolomics via biomedical mass spectrometry: from sampling to clinical applications; Part III. Metabolomics of Biofluids: Nuclear Magnetic Resonance Spectroscopy and Chemometrics: 11. Analytical techniques in metabolomics integrating nuclear magnetic resonance spectroscopy and chromatography with mass spectrometry; 12. Chemometric methods in nuclear magnetic resonance-based body fluid analysis; 13. Nuclear magnetic resonance of cerebrospinal fluid: the neurometabolome; 14. Nuclear magnetic resonance-based saliva metabolomics; 15. Nuclear magnetic resonance methods for metabolomic investigation of amniotic fluid; 16. Nuclear magnetic resonance analysis and genetic metabolic disease; 17. Lipid profiling in health and disease; Part IV. Metabolomic Nuclear Magnetic Resonance Spectroscopy Techniques for Body Tissue Analysis: 18. Magnetic resonance spectroscopy in investigating the cancer metabolome in preclinical model systems; 19. Phospholipidomics by phosphorous nuclear magnetic resonance spectroscopy of tissue extracts; 20. Carbon-13 nuclear magnetic resonance for analysis of metabolic pathways; 21. Hyperpolarized nuclear magnetic resonance spectroscopy - a new method for metabolomic research; 22. Metabolomic magnetic resonance spectroscopy of human tissues: comparison of in vivo and high-resolution magic angle spinning ex vivo techniques; 23. Reproducible sample preparation and spectrum acquisition techniques for metabolic profiling of human tissues by proton high-resolution magic angle spinning nuclear magnetic resonance; 24. Assignment strategies for nuclear magnetic resonances in metabolomics research; Index.

About the Author :
Norbert W. Lutz is Research Professor at the School of Medicine at the University of Aix-Marseille, France. He has previously held positions at the Johns Hopkins University School of Medicine, the German Cancer Research Center, the University of Arizona Cancer Center and other internationally renowned research institutions. His research is primarily focused on the analysis of metabolic processes in cancer and in neurological diseases. His papers have appeared in Analytical Chemistry, Annals of Neurology, PLoS ONE, International Journal of Cancer, AIDS, Metabolomics, NMR in Biomedicine and other journals. Jonathan V. Sweedler is the James R. Eiszner Family Professor of Chemistry and the Director of the School of Chemical Sciences at the University of Illinois at Urbana-Champaign, USA. His major research efforts involve developing new approaches for small-volume peptidomics and metabolomics and the application of these technologies to study novel neuro-chemical pathways. Professor Sweedler has published more than 350 manuscripts, book chapters and reviews and has presented 350 invited lectures relate to research in these areas. He is Editor-in-Chief of Analytical Chemistry. Ron Wevers is head of the laboratory of Genetic Endocrine and Metabolic Diseases of the Radboud University Nijmegen Medical Centre in the Netherlands. He has a chair in Clinical Chemistry of Inborn Errors of Metabolism. Professor Wevers is also a member of the Dutch Health Council. He has co-authored more than 300 peer-reviewed papers and many book chapters and wrote a handbook on body fluid NMR spectroscopy in patients with inborn errors of metabolism.


Best Sellers


Product Details
  • ISBN-13: 9781139602884
  • Publisher: Cambridge University Press
  • Publisher Imprint: Cambridge University Press (Virtual Publishing)
  • Binding: Digital download and online
  • Language: English
  • No of Pages: 272
  • ISBN-10: 1139602888
  • Publisher Date: 10 Dec 2012
  • Binding: Digital download and online
  • Language: English
  • No of Pages: 272
  • Sub Title: Experimental Strategies and Techniques


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Methodologies for Metabolomics: Experimental Strategies and Techniques
Cambridge University Press -
Methodologies for Metabolomics: Experimental Strategies and Techniques
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Methodologies for Metabolomics: Experimental Strategies and Techniques

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!