Topology and Physics of Circular DNA (1992)
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Topology and Physics of Circular DNA (1992): (CRC Press Revivals)
Topology and Physics of Circular DNA (1992): (CRC Press Revivals)

Topology and Physics of Circular DNA (1992): (CRC Press Revivals)


     0     
5
4
3
2
1



Available


X
About the Book

Topology and Physics of Circular DNA presents comprehensive coverage of the physical properties of circular DNA. The author examines how topological constraints arising from cyclization of DNA lead to distinctive properties that make closed molecules radically different from linear DNA. The phenomenon of supercoiling, its geometric and topological analysis, and the formation of noncanonical structures in circular DNA under the influence of supercoiling are emphasized. The combination of consistent theoretical analysis and detailed treatment of major experimental approaches make Topology and Physics of Circular DNA an important reference volume for biophysicists, biochemists, molecular biologists, and researchers and students who want to expand their understanding of circular DNA.

Table of Contents:
Foreword. Introduction. BASIC PHYSICAL PROPERTIES OF DNA. DNA STRUCTURE. Single-Stranded DNA. The Double Helix. Alternative Forms of the Double Helix. Other Regular Structures. Hairpins and Cruciform Structures. FLEXIBILITY OF THE DOUBLE HELIX. Macromolecular Conformation in Solution. Chains with Correlated Direction of Adjacent Links. Persistence Length of DNA. Excluded Volume Effect. Torsional Rigidity of the Double Helix. CONFORMATIONAL TRANSITIONS. General Properties of Conformational Transitions. Statistical-Mechanical Treatment of Conformational Transitions. Helix-Coil Transition. B-A Transition. B-Z Transition. CIRCULAR DNA AND SUPERCOILING. THE CIRCULAR FORM OF DNA. The Discovery of Circular DNA. The Topological Aspect of Inter-Strand Linkage. Linking Number Difference and Superhelical Density: Topoisomers. EXPERIMENTAL STUDIES OF SUPERCOILING. Determining the Linking Number Difference. The Dependence of Superhelical Density on Solution Conditions. Superhelicity of Circular DNA Isolated from Cells. Obtaining DNA with a Preset Superhelical Density. SUPERCOILING ENERGY. TOPOISOMERASES. GEOMETRY AND TOPOLOGY OF CIRCULAR DNA. RIBBON THEORY. Writhe and Twist. Principal Properties of Writhe. CONFORMATIONS OF SUPERCOILED DNA. Torsional Rigidity of the Double Helix. Computer Simulation of Supercoiling. Experimental Studies of Supercoiled DNA Conformations. Thermodynamics of Supercoiling. CYCLIZATION OF DNA. KNOTTED AND LINKED DNA. Types of Knots and Linkages. Theoretical Analysis of Knots and Linkages. Knots and Linkages in DNA. Topological Approach to the Study of the Mechanisms of Enzymatic Reactions. FORMATION OF NONCANONICAL STRUCTURES UNDER THE IMPACT OF NEGATIVE SUPERCOILING. EXPERIMENTAL METHODS OF ANALYSIS OF NONCANONICAL STRUCTURES IN CIRCULAR DNA. Methods of Localization of Structural Transitions. The Method of Two-Dimensional Gel Electrophoresis. THERMODYNAMIC ANALYSIS OF THE FORMATION OF NONCANONICAL STRUCTURES. CRUCIFORM STRUCTURES. THE LEFT-HANDED Z-FORM. MELTING OF CLOSED CIRCULAR DNA. THE H-FORM. THE INFLUENCE OF SUPERCOILING ON THE B-A TRANSITION. STATISTICAL-MECHANICAL ANALYSIS. MUTUAL INFLUENCE AND COMPETITION OF DIFFERENT STRUCTURAL TRANSITIONS. KINETICS OF THE FORMATION OF NONCANONICAL STRUCTURES IN CIRCULAR DNA. THE USE OF CIRCULAR DNA IN STUDIES OF THE DOUBLE HELIX AND ITS GENERAL PROPERTIES. FINDING THE HELICAL REPEAT OF THE DOUBLE HELIX. FINDING THE DOUBLE HELIX UNWINDING ANGLE UPON LIGAND BINDING. DNA SUPERCOILING INSIDE THE CELL. SUPERHELICAL STRESS. EXISTENCE OF NONCANONICAL STRUCTURE WITHIN A CELL. TRANSCRIPTION-INDUCED DNA SUPERCOILING.

About the Author :
Alexander V. Vologodskii is Research Professor of Chemistry Department of Chemistry New York University.


Best Sellers


Product Details
  • ISBN-13: 9781138105058
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: CRC Press
  • Height: 234 mm
  • No of Pages: 192
  • Weight: 453 gr
  • ISBN-10: 1138105058
  • Publisher Date: 02 Oct 2017
  • Binding: Hardback
  • Language: English
  • Series Title: CRC Press Revivals
  • Width: 156 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Topology and Physics of Circular DNA (1992): (CRC Press Revivals)
Taylor & Francis Ltd -
Topology and Physics of Circular DNA (1992): (CRC Press Revivals)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Topology and Physics of Circular DNA (1992): (CRC Press Revivals)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!