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Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Neurology and clinical neurophysiology > Multiple Sclerosis Therapeutics
Multiple Sclerosis Therapeutics

Multiple Sclerosis Therapeutics


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About the Book

This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclini

Table of Contents:
Part I: Introduction. Aspects of Multiple Sclerosis that Relate to Clinical Trial Design and Treatment. Part II: Clinical Trial Methodology. Measures of Impairment and Disability. Assessment of Neuropsychological Function. Health-related Quality of Life Assessment in Multiple Sclerosis. Magnetic Resonance Imaging in Multiple Sclerosis: an Overview. Measures of Gadolinium Enhancement. Measures of Magnetization Transfer. Measures of T1 and T2 Relaxation. Measurement of CNS Atrophy. Measures to Quantify Axonal Damage In Vivo Based on Magnetic Resonance Spectroscopy. Functional Imaging in Multiple Sclerosis. The Use of Cost Analyses to Improve our Understanding of Therapeutic Trade-offs for Multiple Sclerosis. Ethical Considerations in Multiple Sclerosis Clinical Trials. The Process of Drug Development and Approval in the United States, European Union, and Canada. Sponsors, Monitoring Committees, and Investigators: the Investigator's Perspective. Guidelines for Clinical Trials of New Therapeutic Agents in Multiple Sclerosis: Reporting Extended Results from Phase III Clinical Trials. The Failed Clinical Trial. The Challenge of Long-term Studies in MS: Use of Pooled Data, Historical Controls, and Observational Studies to determine efficacy. Part III: Clinical Trials of Disease Modifying Therapy. Emerging Concepts of Pathogenesis: Relationship to MS Therapies. Interferons in Relapsing Remitting MS. Interferons in Secondary Progressive MS. Biologic Mechanisms of Action of Interferons in MS. Glatiramer Acetate. Mitoxantrone. Intravenous Immunoglobin to Treat Multiple Sclerosis. Therapeutic Plasma Exchange for Multiple Sclerosis. Methylprednisolone. Cyclophosphamide Treatment of Multiple Sclerosis. Treatment of Multiple Sclerosis by Hematopoietic Stem Cell Transplantation. Emerging Disease-modifying Therapies. Combination Therapies in Multiple Sclerosis. Sex Hormones and Other Pregnancy Related Factors with Therapeutic Potential in Multiple Sclerosis. Complementary and Altern


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Product Details
  • ISBN-13: 9781135414023
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: CRC Press
  • Language: English
  • No of Pages: 784
  • ISBN-10: 1135414025
  • Publisher Date: 13 Feb 2019
  • Binding: Digital (delivered electronically)
  • No of Pages: 784


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