Lipids and Atherosclerosis
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Lipids and Atherosclerosis: (Advances in Translational Medical Science)

Lipids and Atherosclerosis: (Advances in Translational Medical Science)


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About the Book

New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of s

Table of Contents:
List of contributors vii Foreword xi Preface xiii Acknowledgements xiv 1. The assembly of very low density lipoproteins in the liver 1 S-O. Olofsson and L. Asp 2. Cardiovascular implications of partial, tissue-specific silencing of MTP 15 C.C. Shoulders 3. Acyl CoA: Diacylglycerol acyltransferases (DGATs) as therapeutic targets for cardiovascular disease 31 J.S. Millar and J.T. Billheimer 4. The biochemical and physiological roles of ACAT1 and ACAT2 in cholesterol homeostasis and atherosclerosis 41 R.G. Lee and L.L. Rudel 5. Overview of intestinal lipid metabolism 55 T.A. Miettinen and H. Gylling 6. The role of non-cholesterol sterols in the pathogenesis of atherosclerosis and their modulation by the sitosterolaemia locus 63 E.L. Klett and S.B. Patel 7. FXR: the molecular link between bile acid and lipid metabolism 69 T. Claudel, E. Sturm, B. Staels and F. Kuipers 8. Overview of HDL and reverse cholesterol transport 81 P. Barter 9. LXR as a therapeutic target for atherosclerosis 93 I.G. Schulman and R.A. Heyman 10. Endothelial lipase and the regulation of HDL metabolism 101 K.O. Badellino and W. Jin 11. Cholesteryl ester transfer protein (CETP) inhibition as a therapeutic strategy for raising HDL-cholesterol levels and reducing atherosclerosis 111 D.J. Rader Contents Prelims 14/7/05 4:44 pm Page v 12. Overview of insulin resistance and the metabolic syndrome 119 N. Sattar and B. Mukhopadhyay 13. Peroxisome proliferator activated receptors and energy metabolism 137 P. Gervois, J-C. Fruchart and B. Staels 14. Adipocytes and their secretory products 153 J.B. Prins 15. Regulation of adipocyte triglyceride storage 165 F. Karpe and G.D. Tan 16. Role of innate immunity in atherosclerosis: immune recognition, immune activation and the atherosclerotic process 175 J-M. Fernández-Real 17. Role of CD44 in atherogenesis and its potential role as a therapeutic target 191 E. Puré 18. Lipoxygenases: potential therapeutic target in atherosclerosis 207 L. Zhao and C.D. Funk 19. Role of secretory phospholipase A2 isozymes (Lp-PLA2) 219 C.H. Macphee Index

About the Author :
Daniel J. Rader Chris J. Packard

Review :
'This book provides a comprehensive overview of lipoprotein metabolism, which entails a wide variety of topics spanning several different disciplines. The book will appeal to a wide audience of researchers in the field of cardiovascular disease' Clinical Chemistry Journal


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Product Details
  • ISBN-13: 9781135401320
  • Publisher: Taylor & Francis Ltd
  • Binding: Digital (delivered electronically)
  • Series Title: Advances in Translational Medical Science
  • ISBN-10: 1135401322
  • Publisher Date: 08 Sep 2005
  • Language: English


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Lipids and Atherosclerosis: (Advances in Translational Medical Science)
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