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Studies from the Otho S. A. Sprague Memorial Institute Volume 3; Collected Reprints

Studies from the Otho S. A. Sprague Memorial Institute Volume 3; Collected Reprints


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This historic book may have numerous typos and missing text. Purchasers can download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1915 Excerpt: ...be obtained with the higher members of the same series. The mechanism by which chloroform produces its characteristic tissue changes must accordingly be considered as a group reaction. Outside the body the similarities between the chemical behavior of different members of this group have been correlated by Nef on the basis of the type of dissociation which these substances undergo and the differences in their behavior on the basis of the differences of the degree to which such dissociations occur. According to the work of Nef, the group of substances under discussion has the property of dissociating to yield a halogen acid and an unsaturated alkylidene rest. Thus with chloroform the type of dissociation may be expressed thus: CHC13CC12 + HC1. A In this paper the view is developed that the changes characteristic of late poisonings with the above named group, namely edema, multiple hemorrhages, fat infiltration, and necrosis are ascribable (I) to acids and (2) to the fact that the amount of acid formed parallels the chemical dissociability of the drug outside of the body. Favoring the view that acid is responsible for the changes are the following observations. 1. All the characteristic features of late chloroform poisoning have been produced merely by the administration of hydrochloric acid, except, however, for a different distribution of the liver necrosis. 2. The areas of central necrosis produced in the liver by the various substances under discussion give an acid reaction to neutral red. 3. Sodium carbonate in a hypertonic sodium chloride solution markedly inhibits the production of the lesions. In favor of the view that the respective halogen acids play an important part are the following. 1. After the administration of some of these drugs there has be...



Product Details
  • ISBN-13: 9781130959949
  • Publisher: Rarebooksclub.com
  • Publisher Imprint: Rarebooksclub.com
  • Height: 246 mm
  • No of Pages: 130
  • Spine Width: 7 mm
  • Width: 189 mm
  • ISBN-10: 1130959945
  • Publisher Date: 01 Mar 2012
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 245 gr


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Studies from the Otho S. A. Sprague Memorial Institute Volume 3; Collected Reprints
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