Liver Transplantation: Clinical Assessment and Management

Explore this practical and step-by-step guide to managing liver transplant patients from leading international clinicians in Hepatology  The newly revised Second Edition of Liver Transplantation: Clinical Assessment and Management delivers expert clinical guidance on best practices in managing the care of liver transplant patients. Authors are all experts in their field and cover a world-wide perspective. Organized in an accessible, stepwise fashion and packed with text features such as key points, the book covers all critical areas of each stage of the liver transplant journey, from assessment, to management on the list, to long term care.  Readers will learn when to refer a patient for liver transplantation, how to assess a potential liver transplant recipient, learn the principles of the procedure and the long term management of the transplant recipient. Liver Transplantation provides the entire hepatology and surgical team the information required for a sound understanding of the entire procedure, from pre- to post-operative care and management.  Clinically oriented and management-focused, the book is far more accessible than the liver transplant sections in traditional hepatology textbooks. Readers will also enjoy:  A thorough discussion of when to refer a patient for liver transplantation, including general considerations and the use and abuse of prognostic models  An exploration of the selection, assessment, and management of patients on the transplant list, including how to manage a patient with chronic liver disease while on the waiting list  A treatment of liver transplantation for acute liver failure (ALF), including assessment and management of ALF patients on the transplant waiting list  A discussion of care of the liver transplant recipient after the procedure in the short and long term   Perfect for gastroenterologists, hepatologists, and surgeons and other health care professionals managing patients with liver disease who are awaiting, undergoing and following liver transplantation, Liver Transplantation: Clinical Assessment and Management will also earn a place in the libraries of medical students, residents, internal medicine physicians, and GI/Hepatology trainees and all health care professionals providing clinical care to people with liver disease, before, during and after transplantation. 

Table of Contents:
List of Contributors x Foreword to the Second Edition xx Foreword to the First Edition xxi Preface xxii Abbreviations xxiii Part 1 When to Refer a Patient for Liver Transplantation 1 1 Overview on Organ Donation and Liver Transplantation 3 Michael Ronan Lucey 2 Predicting Outcomes and Use and Abuse of Prognostic Models 11 Moira B. Hilscher and Patrick S. Kamath Part 2 Selection, Assessment, and Management on the List 19 3 Assessment of the Potential Transplant Recipient 21 Michael L. Volk 4 Frailty and the Potential Liver Transplant Candidate 27 Matthew J. Armstrong and Jennifer C. Lai 5 Alcohol Use (excluding Alcohol-Related Liver Disease), Tobacco, Marijuana, and Illicit Drugs 33 John P. Rice 6 The Role of the Psychiatric Consultant in the Selection, Assessment, and Management of Liver Transplant Patients 39 Robert M. Weinrieb and Arpita Goswami-Banerjee 7 When Liver Transplant Patients Do Not Adhere to Therapeutic Plans 48 Kerry Webb and Rowena Jones 8 Liver Transplant Assessment for Young People: Addressing the Needs of Young People with Liver Disease 55 Marianne Samyn and Jemma Marie Day 9 Assessment and Management of the Patient with Hepatitis C 64 Emma L. Hathorn and David J. Mutimer 10 Management of Hepatitis B Virus Infection Pre Transplantation 68 Bruno Roche and Didier Samuel 11 Transplantation for the Management of Malignancy 74 Adiba I. Azad, Julie K. Heimbach, and Gregory J. Gores 12 Assessment and Management of the Liver Transplant Candidate with Acute-on-Chronic Liver Failure 82 Giovanni Perricone and Rajiv Jalan 13 Assessment and Management of the Transplant Candidate with Alcohol-Associated Liver Disease 96 Stéphanie Faure, Magdalena Meszaros, Lucy Meunier, Hélène Donnadieu-Rigole, and Georges-Philippe Pageaux 14 Non-alcoholic Fatty Liver Disease as an Indication for Liver Transplantation 104 Paul Horn and Philip N. Newsome 15 Consent 109 Christopher J.E. Watson 16 Prehabilitation and General Management 116 Matthew J. Armstrong and Felicity R. Williams 17 Removal of Patients from the Liver Transplant Waiting List 123 John O’Grady 18 Palliative Care and Liver Transplantation 126 Mina Rakoski and Puneeta Tandon Part 3 Transplantation for Acute Liver Failure 135 19 Assessment of the Patient with Acute Liver Failure 137 Ashley Barnabas and John O’Grady 20 Management of the Patient with Fulminant Hepatic Failure Awaiting Liver Transplantation 143 Robert J. Fontana Part 4 Donation and Allocation 153 21 Ethical and Legal Aspects of Organ Donation 155 Jessica Mellinger 22 Liver Allocation, Including Principles of Organ Allocation 161 Parita Patel and Michael Charlton 23 Living Donor Liver Transplant in Children 168 Adebowale A. Adeyemi, Elizabeth B. Rand, and Kim M. Olthoff 24 Living Liver Donation in Adults 180 Mohamed Rela and Ashwin Rammohan 25 Deceased Liver Donors: Standard and Expanded Criteria 190 Shareef Syed and Sandy Feng 26 Donor-Transmitted Disease 203 James Neuberger 27 Liver Donation and Preservation 209 Navneet Tiwari and Hynek Mergental 28 Liver Retrieval and Preservation 223 Carlo D.L. Ceresa, Brian R. Davidson, Peter J. Friend, and Rutger J. Ploeg 29 Alternatives to Whole Graft Liver Transplantation 236 Paolo Muiesan, Alessandro Parente, and Hector Vilca-Melendez 30 Surgical Aspects of Deceased Donor Transplantation 252 Amit Nair, K.V. Narayanan Menon, Cristiano Quintini, and Charles Miller Part 5 Care of the Liver Transplant Recipient 265 31 Outcomes after Liver Transplantation 267 James Neuberger 32 Outpatient Follow-Up of Liver Transplant Recipients 276 Amardeep Khanna and James Ferguson 33 Medication Adherence 285 Maureen Whitsett and Josh Levitsky 34 Transitional Care 299 Fiona Thompson 35 Managing the Liver Transplant Recipient with Abnormal Liver Blood Tests 303 Joanna A. Leithead 36 The Immune System in Liver Transplantation: Rejection versus Tolerance 317 Palak J. Trivedi and Nick D. Jones 37 Immunosuppressive Medications: Liver Transplantation 334 Tim Mitchell and Gerry MacQuillan 38 Immunosuppression in Liver Transplantation 344 Nicholas Lim and John R. Lake 39 Patterns of Liver Allograft Rejection 353 Geoffrey W. McCaughan, Ken Liu, Avik Majumdar, Patrick Bertolino, David G. Bowen, and Simone I. Strasser 40 De Novo Autoimmune Hepatitis 360 James Neuberger 41 Managing Rejection 364 Neil Halliday and Douglas Thorburn 42 Withdrawal of Immunosuppression after Liver Transplantation 386 Luca Toti, Tommaso Maria Manzia, Francesca Blasi, and Giuseppe Tisone 43 Liver Transplant Pathology 393 Owen L. Cain and Stefan G. Hübscher 44 Care of the Liver Transplant Recipient: Management of Renal Function 403 Andres F. Carrion and Paul Martin 45 Managing Cardiovascular Risk in the Liver Transplant Recipient 409 Manhal Izzy and Kymberly D. Watt 46 Bone Disease in Liver Transplantation 418 John Ayuk 47 Diagnosis and Management of Recurrent Autoimmune Liver Disease 424 Fernanda Q. Onofrio, Nazia Selzner, and Gideon M. Hirschfield 48 NAFLD and NASH in the Patient after Liver Transplantation 438 Paul Horn and Philip N. Newsome 49 Recurrent Metabolic Diseases 445 James Neuberger 50 Treatment of Hepatitis C in the Transplant Setting 449 Jeffrey Kahn and Norah A. Terrault 51 Management of Hepatitis B Virus Infection Post Transplantation 458 Bruno Roche and Didier Samuel 52 Antimicrobial Prophylaxis Following Liver Transplantation 469 Michael J. Williams and Peter C. Hayes 53 Cytomegalovirus and the Liver Transplant Recipient 475 James Ferguson 54 Post-Liver Transplant Infections 481 Miruna David and Ahmed Elsharkawy 55 De Novo Malignancies after Liver Transplantation 493 Simone I. Strasser, Ken Liu, Avik Majumdar, and Geoffrey W. McCaughan 56 Post-Transplant Lymphoproliferative Disorders 500 Jose Ignacio Herrero 57 Quality of Life and Employment after Liver Transplantation 507 Santiago Tome, Esteban Otero, and Michael Ronan Lucey 58 Sexual Function, Fertility, and Pregnancy in Liver Disease and after Liver Transplantation 514 Patrizia Burra, Salvatore Stefano Sciarrone, and Patrizio Bo 59 Common Drug Interactions 519 Amanda Smith 60 Immunization and Liver Transplantation 525 Jessica Hause and Erin Spengler Postscript 529 James Neuberger Index 531

About the Author :
JAMES NEUBERGER, DM, FRCP is Consultant Physician in the Liver Unit, Birmingham, UK. A previous President of the British Association for the Study of the Liver, he has over 35 years of liver transplantation and disease experience and has edited five books on liver disease and liver transplantation and published extensively in liver disease and transplantation. JAMES FERGUSON, MD, FRCPE is Consultant Hepatologist at the Queen Elizabeth Hospital in Birmingham, UK. He has extensive experience in managing patients with liver disease and in liver transplantation. PHILIP N. NEWSOME, PHD, FRCPE is Professor of Experimental Hepatology and Honorary Consultant Hepatologist, Director of Research and Knowledge Transfer for the College of Medical & Dental Sciences and Director of the Centre for Liver and Gastrointestinal Research in the University of Birmingham, UK. Currently Secretary General of the European Association for the Study of the Liver, he continues to research in all aspects of liver disease and stem cell therapy. MICHAEL RONAN LUCEY, MD, FRCPI is Chief of the Division of Gastroenterology and Hepatology at the University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. A past President of the American Society of Transplantation, he continues to publish widely in the field of liver disease and liver transplantation.