Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease, 2 Volume Set

Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease Comprehensive textbook covering all aspects of the care of patients with advanced heart or lung disease Transplantation and Mechanical Support for End-Stage Heart and Lung Disease is the most comprehensive and contemporary textbook available that addresses the medical and surgical treatment options for patients with end-stage heart and lung disease. All facets of these complex and resource-intensive therapies are covered by leading experts — including the basics of transplant immunology, databases, regulatory and ethical aspects of transplantation and conventional and new modalities of donor organ harvest. Transplantation and Mechanical Support for End-Stage Heart and Lung Disease includes further information on topics such as: Historical developments that facilitated heart and lung transplantation; engineering advances in continuous flow technologies Transplant organizations, oversight, structure, process, databases and registries in the thoracic transplants and MCS field Current strategies in immune modulation, desensitization protocols and mechanisms of allograft rejection and tolerance/immunosenescence Detailed descriptions of donor and recipient surgical procedures as well as comprehensive implantation techniques for all available short- and long-term mechanical circulatory support devices, including ECMO Organ allocation and prioritization, donor evaluation, high risk donors, marginal donors, and risk assessment Richly enhanced with summary tables and color illustrations to provide an engaging and supportive learning experience, the book will serve as a highly valuable source of contemporary knowledge for medical students, residents, nurses, perfusionists, physicians and surgeons involved in the care of these desperately ill group of patients. “This comprehensive book covers all aspects of advanced heart and lung failure treatment, including shock, short-term and durable mechanical assistance, as well as transplantation. The in-depth information will be welcome by newcomers in the field as well as seasoned veterans.” —Andreas Zuckermann, M.D Vice-Chair, Department of Cardiac Surgery, Director of Cardiac Transplantation Program, Medical University of Vienna, Vienna General Hospital “This comprehensive tour-de-force compendium covers practical issues of clinical administration, program development, care pathways, ongoing challenges and opportunities in each treatment area as a must go-to reference for guidance in the rapidly evolving fields of mechanical circulatory support and transplantation.” —Mandeep R. Mehra, MBBS, MSc, FRCP Executive Director, Center for Advanced Heart Disease, Brigham and Women’s Hospital, Harvard Medical School “This unique textbook authored by key opinion leaders is a refreshing 'wind of change' in our field, one that will well serve all professionals involved in the care of end-stage heart and lung patients for many years to come.” —Marcelo Cypel MD, MSc, FACS, FRCSC Surgical Director Ajmera Transplant Centre at UHN , University of Toronto

Table of Contents:
Section IX The MCS Patient 785 Stephan Schueler 56 Postoperative ICU Care for Mechanical Circulatory Support Patients 787 Nicholas C. Cavarocchi 57 Post-ICU LVAD Course 797 Melissa Lyle and Divya Gupta 58 The VAD Coordinator's Role: Education and Team Communication 805 Heidi Craddock and Christy Kay 59 The LVAD Patient Bridging to Wellness: Psychological Assessment and Rehabilitation 812 Mary Amanda Dew 60 LVAD Clinic: Outpatient Monitoring and Causes for Readmission 833 Nancy K. Sweitzer and Sophia Airhart 61 Hemodynamic Optimization of the LVAD Patient 849 Nikhil Narang, Gabriel Sayer, and Nir Uriel 62 Myocardial Recovery During LVAD Support 858 Christos P. Kyriakopoulos, Craig H. Selzman, and Stavros G. Drakos Section X MCS-Related Complications in the Chronic Patient 881 Joseph G. Rogers 63 Right Heart Failure: Risk Scores and Management 883 Brent C. Lampert and Jeffrey J. Teuteberg 64 LVAD-Associated Acquired von Willebrand Syndrome and Gastrointestinal Bleeding: Pathophysiology, Etiologies, and Management 898 Sanjhai L. Ramdeen and Carlo R. Bartoli 65 Mechanical Circulatory Support Infections 907 Gerard Giblin, Ciara O’Connor, Emer Joyce, and Margaret M. Hannan 66 Pump Thrombosis: Medical and Surgical Management 932 Andrew Xanthopoulos, Filippos Triposkiadis, and Randall C. Starling 67 Neurologic Complications: Pathophysiology, Incidence, Types, Prevention, and Management 945 Paolo C. Colombo, Chinwe Ibeh, Kara R. Melmed, and Joshua Willey 68 Renal Dysfunction in MCS Patients: Perioperative and Long-Term Considerations 966 Natasha A. Vedage and Meredith A. Brisco-Bacik 69 De Novo Aortic Insufficiency 977 Jennifer Cowger Section XI The LVAD Program and Future Directions 987 Daniel J. Goldstein 70 Regulatory and Miscellaneous Aspects of an LVAD Program 989 Christina Cheyne, Igor Gosev, and Sunil Prasad 71 Current Limitations and Characteristics of Next-Generation Ventricular Assist Devices 996 Yuji Kaku, Yoshifumi Naka, and Daniel Burkhoff 72 MCS and Novel Adjunctive Therapies: An Update 1011 Doris A. Taylor, Lourdes I. Chacon, Camila Hochman-Mendez, and Luiz C. Sampaio 73 Artificial Intelligence and Machine Learning in MCS 1021 Manreet Kanwar, Marek J. Druzdzel, Faezeh Movahedi, and Jim Antaki Lung Transplant Section XII The Pretransplant Phase: Recipient 1035 Mani A. Daneshmand 74 Recipient Selection and the Lung Transplant Window for Adult and Pediatric Patients 1037 David C. Neujahr and William R. Hunt 75 Advanced Lung Disease 1053 Cynthia Jane Gries 76 The Acute Lung Failure Patient and Temporary Mechanical Support 1070 Purav Shah, Maria C. Creel, and Satish Chandrashekaran 77 Preoperative Optimization for Lung Transplant 1081 Andrew M. Vekstein, John C. Haney, John M. Reynolds, and Jacob A.Klapper 78 Lung Transplant Waitlist Management 1089 Joshua B. Smith and Alice L. Gray Section XIII The Pretransplant Phase: Donor 1101 Yaron D. Barac 79 Prioritization: Candidate Selection and Organ Allocation Systems 1103 Are Martin Holm andMatthew G. Hartwig 80 Donor Lungs Evaluation 1110 Louis Stein, Alex Leung, Yaron D. Barac, Mani A. Daneshmand, and Yuri Pesachovitz 81 Lung Transplantation: Marginal Donors and Risk Assessment 1119 Laura L. Donahoe and Shaf Keshavjee 82 Organ Procurement and Preservation 1132 Reshma Biniwale and Abbas Ardehal 83 Machines and Donation After Circulatory Death (DCD) in Lung Transplantation 1145 Gabriel Loor and Pablo Sanchez Section XIV The Transplant Phase 1163 Mani A. Daneshmand 84 Components of the Lung Transplant Team 1165 Keshava Rajagopal 85 Anesthesia and Hemodynamic Management for Lung Transplantation 1167 Angela Pollak, Charles Overbeek, and Brandi Bottiger 86 Techniques in Lung Transplantation 1183 Maziar Khorsandi, Jeffrey Keenan, and Matthew Hartwig 87 Technical Considerations in the Complex Recipient 1193 Jamil F. Borgi and Stephen J. Forest 88 Taking the First Breath: ICU Care of the Lung Transplant Patient 1204 Daniel Herr and Patrick Odonkor Section XV The Post-Transplant Phase 1215 Yaron D. Barac 89 Post-Transplant Phase: Issues in the Early Postoperative Period 1217 John Mackintosh and Peter Hopkins 90 Post-Transplant Phase: From ICU Discharge to Hospital Discharge 1240 Osnat Shtraichman and Mordechai R. Kramer 91 Lung Transplant Rejection 1268 Caroline Patterson and Martin Goddard 92 Transplant Infectious Diseases 1288 Grace Chan, Breda Lynch, Michelle Murray, and Margaret M. Hannan 93 Post-Transplant Complications 1317 Jagan Murugachandran, Debra Thomas, and Jasvir Parmar 94 Post-Transplant Other Adverse Events 1333 Andres Pelaez and Karoun H. Bagamian 95 Survival and Quality of Life Post Lung Transplantation 1345 Attawar Sandeep, Vijil Rahulan, and Unmil Shah Section XVI Thoracic Transplant in a Long-Term Perspective 1359 Mani A. Daneshmand 96 The Future of Heart and Lung Transplantation 1361 Jane M.O., David C. Becerra, and Joren C. Madsen 97 Heart and Lung Xenotransplantation 1389 Jane O., Cynthia L. Miller, and Joren C. Madsen Index 1404

About the Author :
Yaron D. Barac, M.D, Ph.D Associate Professor of Surgery and Cardiovascular Physiology; Director of the Heart and Lung Transplantation and Mechanical Circulatory Support Programs; Director of The Cardiothoracic Surgery Translational Research Lab. The Division of Cardiovascular and Thoracic Surgery, Rabin Medical Center, Tel Aviv University, Israel. Scott C. Silvestry, M.D Co-Executive Medical Director, Heart, Lung, and Vascular Institute. Surgical Director, Thoracic Transplant Programs. AdventHealth Transplant Institute, AdventHealth Orlando. Mani A. Daneshmand, M.D Andrew J. McKelvey Professor of Lung Transplant Surgery. Director, Section of Thoracic Transplant and MCS Surgery. Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine. Daniel J. Goldstein, M.D Professor and Vice-Chair, Surgical Director, Cardiac Transplantation & Mechanical Assistance Programs, Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center, Albert Einstein College of Medicine.