Pathology of Genetically Engineered and Other Mutant Mice

An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Table of Contents:
List of Contributors vii Preface and Acknowledgments x 1 Introduction to Mouse Pathology 1 Jerrold M. Ward, Peter Vogel, and John P. Sundberg 2 The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research 6 Dale A. Begley, Paul N. Schofield, and John P. Sundberg 3 Mouse Genetic Nomenclature: The Underpinning of Mouse Genetics 22 John P. Sundberg, Dale A. Begley, Melissa L. Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield 4 Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect 39 John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofield 5 Embryos, Placentas, and Neonates 48 Brad Bolon and Jerrold M. Ward 6 Ciliopathies 72 Peter Vogel and Laura J. Janke 7 Hematopoietic and Lymphoid Tissues 82 Harm HogenEsch and John P. Sundberg 8 Mouse Hematolymphoid Neoplasms 97 Jerold E. Rehg 9 Immunodeficient and Humanized Mice 132 Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch 10 Skin, Hair, and Nails 159 John P. Sundberg, Lloyd E. King, Jr, and Raoul V. Kuiper 11 Mammary Gland 213 Alexander D. Borowsky and Robert D. Cardiff 12 The Respiratory Tract 237 Jerrold M. Ward and John P. Sundberg 13 The Gastrointestinal Tract 259 Jerrold M. Ward, Piper M. Treuting, and M. Kay Washington 14 Cardiovascular System 284 Kathleen L. Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy K. Cooper 15 Liver and Pancreas 307 Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger 16 Neuromuscular System 336 Peter Vogel, Laura J. Janke, and Heather W. Sheppard 17 Endocrine System 355 Krista M. D. La Perle 18 Kidney and Urinary Bladder 378 Jeffrey B. Kopp, Avi Z. Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, and Jerrold M. Ward 19 Female Reproductive System 403 Darlene Dixon and Alexander Yu. Nikitin (In Memory of Dr. Joel Mahler) 20 Male Reproductive System 431 Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, and Robert D. Cardiff 21 Nervous System 462 Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli 22 Eye and Ear 493 Heather W. Sheppard, Laura J. Janke, Jerold E. Rehg, and Peter Vogel 23 Bones and Teeth 520 Peter Vogel, John P. Sundberg, and Cheryl Ackert-Bicknell Index 541

About the Author :
The editors John P. Sundberg, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA. Peter Vogel, DVM, PhD, DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children's Research Hospital in Memphis, Tennessee, USA. Jerrold M. Ward, DVM, PhD, DACVP, FIATP,is an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.