Inflammatory Bowel Diseases: A Clinician's Guide

Inflammatory Bowel Diseases: A Clinician’s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterology trainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use. Written by the experts, Inflammatory Bowel Diseases: A Clinician’s Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease.

Table of Contents:
Preface ix Section I Pathogenesis and Clinical Features 1 1 Epidemiology and Pathogenesis 3 Clinical Take Home Messages 3 Epidemiology 3 Pathogenesis 6 Genetics 6 Microbiome 8 Environmental Triggers 9 Case Studies and Multiple Choice Questions 12 References 13 Answers to Questions 15 2 Clinical Features and Diagnosis of Crohn’s Disease 17 Clinical Take Home Messages 17 Clinical Features 19 Disease Course and Natural History 20 Diagnosis 21 History and Physical Examination 21 Laboratory Investigations 22 Serologic Markers 23 Endoscopy 23 Histology 25 Imaging Studies 25 Case Studies and Multiple Choice Questions 27 References 28 Answers to Questions 31 3 Clinical Features and Diagnosis of Ulcerative Colitis 33 Clinical Take Home Messages 33 Clinical Features 34 Disease Course and Natural History 35 Diagnosis 35 History and Physical Examination 36 Laboratory Investigations 36 Serologic Markers 37 Endoscopy 37 Histology 39 Imaging Studies 40 Differential Diagnosis (UC and CD) 40 Case Studies and Multiple Choice Questions 44 References 45 Answers to Questions 47 4 Extraintestinal Manifestations of Inflammatory Bowel Diseases 49 Clinical Take Home Messages 49 Arthritis and Arthropathy 50 Metabolic Bone Disease 51 Cutaneous Manifestations 52 Hepatobiliary Manifestations 53 Ophthalmologic Manifestations 55 Renal Complications 55 Thromboembolic and Cardiovascular Complications 56 Case Studies and Multiple Choice Questions 57 References 58 Answers to Questions 61 Section II Therapeutic Agents 63 5 Aminosalicylates 65 Clinical Take Home Messages 65 Efficacy in Ulcerative Colitis 66 Efficacy in Crohn’s Disease 68 Safety 68 Multiple Choice Questions 70 References 71 Answers to Questions 73 6 Corticosteroids 75 Clinical Take Home Messages 75 Efficacy in Ulcerative Colitis 76 Efficacy in Crohn’s Disease 77 Safety 78 Case Studies and Multiple Choice Questions 80 References 81 Answers to Questions 83 7 Immunomodulators 85 Clinical Take Home Messages 85 Thiopurines 85 Efficacy in Ulcerative Colitis 87 Efficacy in Crohn’s Disease 88 Safety 89 Methotrexate 90 Efficacy in Ulcerative Colitis 90 Efficacy in Crohn’s Disease 91 Safety 91 Calcineurin Inhibitors 91 Efficacy in Ulcerative Colitis 91 Efficacy in Crohn’s Disease 93 Case Studies and Multiple Choice Questions 94 References 95 Answers to Questions 99 8 Biologic Therapies 101 Clinical Take Home Messages 101 Infliximab 102 Efficacy in Ulcerative Colitis 102 Efficacy in Crohn’s Disease 105 Safety 108 Adalimumab 110 Efficacy in Ulcerative Colitis 110 Efficacy in Crohn’s Disease 111 Certolizumab Pegol 112 Efficacy in Crohn’s Disease 113 Newer Therapies 115 Case Studies and Multiple Choice Questions 116 References 117 Answers to Questions 121 9 Antibiotics 123 Clinical Take Home Messages 123 Efficacy in Ulcerative Colitis 123 Efficacy in Crohn’s Disease 124 Other Microbial Modification Methods – Probiotics and Fecal Microbiota Transplantation 125 Multiple Choice Questions 126 References 127 Answers to Questions 129 Section III Management 131 10 Medical Management of Ulcerative Colitis 133 Clinical Take Home Messages 133 Assessment of Extent, Activity, and Severity 133 Limited Colitis – Proctitis, Proctosigmoiditis, and Left‐sided Colitis 135 Pancolitis 136 Mild to Moderate Disease 137 Moderate to Severe Disease 138 Severe Disease 140 Case Studies and Multiple Choice Questions 142 References 144 Answers to Questions 146 11 Medical Management of Crohn’s Disease 149 Clinical Take Home Messages 149 Mild to Moderate Disease 150 Moderate to Severe Disease 151 Case Studies and Multiple Choice Questions 154 References 156 Answers to Questions 157 12 Surgical Management of Inflammatory Bowel Diseases 159 Clinical Take Home Messages 159 Surgery for Ulcerative Colitis 159 Pouch‐related Complications in Ulcerative Colitis 161 Surgery for Crohn’s Disease 163 Prophylaxis for Prevention of Postoperative Recurrence in Crohn’s Disease 164 Case Studies and Multiple Choice Questions 167 References 168 Recommended Reading 169 Answers to Questions 170 13 Complications of Inflammatory Bowel Diseases 171 Clinical Take Home Messages 171 Complications of Ulcerative Colitis 172 Toxic Megacolon and Perforation 172 Colonic Strictures 173 Clostridium difficile and Cytomegalovirus Colitis 173 Colorectal Dysplasia and Cancer 174 Magnitude and Risk Factors 174 Surveillance for Dysplasia and Cancer 175 Management of Dysplasia 175 Chemoprevention 176 Complications of Crohn’s Disease 176 Fibrostenosis and Strictures 176 Abscesses 177 Fistulizing Crohn’s Disease 178 Small‐bowel Cancer 181 Case Studies and Multiple Choice Questions 182 References 184 Answers to Questions 187 Section IV Special Considerations 189 14 Nutrition in Inflammatory Bowel Diseases 191 Clinical Take Home Messages 191 Malnutrition and Micronutrient Deficiencies 191 Dietary Therapies for Inflammatory Bowel Diseases 193 Case Studies and Multiple Choice Questions 194 References 195 Answers to Questions 197 15 Pregnancy, Conception, and Childbirth 199 Clinical Take Home Messages 199 Fertility 199 Effect of Pregnancy on Disease 200 Effect of Disease on Pregnancy 200 Maternal Medication Use During Pregnancy 201 Paternal Medication Use 203 Inheritance 203 Case Studies and Multiple Choice Questions 204 References 205 Answers to Questions 207 16 Inflammatory Bowel Disease During Childhood and Adolescence 209 Clinical Take Home Messages 209 Epidemiology and Clinical Features 209 Treatment of Pediatric Inflammatory Bowel Disease 210 Very Early‐onset Inflammatory Bowel Disease 211 Transition of Care in Pediatric Crohn’s Disease 211 Case Studies and Multiple Choice Questions 213 References 214 Answers to Questions 216 Index 217

About the Author :
Ashwin N. Ananthakrishnan MD, MPH, Assistant Professor of Medicine, Harvard Medical School; Director, Crohn’s and Colitis Center, Massachusetts General Hospital, Boston, MA, USA. Ramnik J. Xavier MD, Kurt Isselbacher Professor of Medicine, Harvard Medical School; Chief of Gastroenterology, Massachusetts General Hospital; Institute Member, Broad Institute of MIT and Harvard, Boston, MA, USA. Daniel K. Podolsky MD, President, University of Texas Southwestern Medical Center; Professor of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX, USA.

Review :
“This is a valuable book that everybody taking care of IBD patients should have. It is very concise but at the same time very complete” Henrique Fernandez, MD, FACP, Parkview Medical Center on behalf of Doody’s