Molecular and Biochemical Toxicology

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. •    Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies •    Uses a didactic approach with basic biological or theoretical background for the methodology presented •    Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology •    Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts •    “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Table of Contents:
Preface xxix List of Contributors xxxi Section 1 Introduction 1 1 Molecular and Biochemical Toxicology: Definition and Scope 3 Ernest Hodgson and Robert C. Smart Section 2 Techniques in Biochemical and Molecular Toxicology 11 2 Molecular Techniques for the Study of Gene Function 13 Yoshiaki Tsuji and Robert C. Smart 3 Transcriptomics 55 B. Alex Merrick 4 Proteomics 91 Michael S. Bereman 5 Metabolomics 115 Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell 6 Cellular Techniques 135 Sharon A. Meyer and Barbara A. Wetmore 7 Basic Concepts of Molecular Epidemiological Research Methods 159 Cathrine Hoyo, David A. Skaar, and Randy L. Jirtle Section 3 Mechanisms in Molecular and Biochemical Toxicology 187 8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189 Ernest Hodgson 9 Structure, Mechanism, and Regulation of Cytochromes P 450 209 John M. Seubert, Matthew L. Edin, and Darryl C. Zeldin 10 Polymorphisms in Phase I and Phase II Genes and Outcomes 239 Yoshiaki Tsuji, Edward L. Croom, and Ernest Hodgson 11 Cellular Transport and Elimination 273 David S. Miller and Ronald E. Cannon 12 Nuclear Receptors 293 Seth W. Kullman, William S. Baldwin, and Gerald A. LeBlanc 13 Mechanisms of Cell Death 327 Mac Law and Susan Elmore 14 Mitochondrial Dysfunction 371 Jun Ninomiya‐Tsuji 15 Reactive Metabolites, Reactive Oxygen Species (ROS), and Toxicity 391 Elizabeth L. MacKenzie and Yoshiaki Tsuji 16 DNA Damage and Mutagenesis 421 Zhigang Wang 17 DNA Repair 485 Isabel Mellon 18 Carcinogenesis 535 Robert C. Smart and Jonathan R. Hall Section 4 Molecular and Biochemical Aspects of Organ Toxicology 589 19 Molecular Mechanisms of Respiratory Toxicity 591 James C. Bonner 20 Molecular Mechanisms of Hepatotoxicity 629 Supriya R. Kulkarni, Andrew D. Wallace, Sharon A. Meyer, and Angela L. Slitt 21 Molecular Mechanisms of Renal Toxicology 665 Lawrence H. Lash 22 Molecular Mechanisms of Neurotoxicity 709 Kimberly P. Keil, Marianna Stamou, and Pamela J. Lein 23 Molecular Mechanisms of Immunotoxicity 773 Tai L. Guo, Joella Xu, Yingjia Chen, Daniel E. Lefever, Guannan Huang, and David A. Lawrence 24 Molecular Mechanisms of Reproductive Toxicity 823 Ayelet Ziv‐Gal, Catheryne Chiang, and Jodi Anne Flaws 25 Molecular Mechanisms of Developmental Toxicity 851 Antonio Planchart Section 5 Emerging Areas in Molecular and Biochemical Toxicology 877 26 Computational and Molecular Approaches to Risk Assessment 879 Richard S. Judson, John Wambaugh, Kristin Isaacs, and Russell S. Thomas 27 Nanotoxicology 909 James C. Bonner 28 Developmental Origins of Health and Disease 933 Michael Cowley 29 Exposome 945 Stephen M. Rappaport Index 969

About the Author :
ROBERT C. SMART, PhD, is a William Neal Reynolds Professor of Toxicology, the Director of the Center for Human Health and the Environment, and the former Director of the Toxicology Graduate Program at North Carolina State University. Together with Dr. Hodgson, he coedited the two previous editions of this book. ERNEST HODGSON, PhD, is Distinguished Professor Emeritus of Environmental and Molecular Toxicology and Executive Director of the Foundation for Agromedicine and Toxicology at North Carolina State University. Alongside the previous editions of this book, he edited four editions of A Textbook of Modern Toxicology (Wiley) and is the Editor of the Journal of Biochemical and Molecular Toxicology.