Practical Transfusion Medicine

Practical Transfusion Medicine, Fourth Edition Edited by Michael F. Murphy, Professor of Blood Transfusion Medicine, University of Oxford; Consultant Haematologist, NHS Blood and Transplant and Oxford University Hospitals, Oxford, UK Derwood H. Pamphilon, formerly Consultant Haematologist, NHS Blood and Transplant; Honorary Clinical Reader, Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK Nancy M. Heddle, Director, MTRP, Professor, Department of Medicine, McMaster University, Hamilton, Ontario, Canada   The pace of change in transfusion medicine is relentless, with new scientific and technological developments. In addition, efforts are continuing to improve clinical transfusion practice and avoid the use of blood wherever possible. This fourth edition continues to be a concise and comprehensive guide to transfusion medicine. It has been thoroughly revised and updated throughout. The scope of the book has been broadened by including more international authors and a new co-editor, Professor Nancy Heddle, an expert in evidence-based transfusion medicine. Practical Transfusion Medicine is divided into seven main parts, each of which guide the reader systematically through the key areas of the speciality: -       Principles of transfusion medicine -       Complications of transfusion -       Practice in blood centres and hospitals -       Clinical transfusion practice -       Alternatives to transfusion -       Cellular and tissue therapy and organ transplantation -       Development of the evidence base for transfusion This book is ideal for trainee/resident haematologists revising for examinations and as a reference source for clinical and scientific staff working in the field of transfusion medicine. Titles of related interest Klein: Mollison’s Blood Transfusion in Clinical Medicine, 11e ISBN 9780632064540 (forthcoming 2013) De Vries: Hemovigilance: An Effective Tool for Improving Transfusion Safety ISBN 9780470655276 (August 2012) McCullough: Transfusion Medicine, 3e ISBN 978144433705 (December 2011)  

Table of Contents:
List of contributors, ix Preface to the Fourth Edition, xvi 1 Introduction: recent evolution of transfusion medicine, 1 Paul M. Ness Part One: Basic Principles of Immunohaematology 2 Essential immunology for transfusion medicine, 11 Jaap Jan Zwaginga & S. Marieke van Ham 3 Human blood group systems, 21 Geoff Daniels 4 Human leucocyte antigens, 31 Cristina V. Navarrete 5 Platelet and neutrophil antigens, 45 David L. Allen, Geoffrey F. Lucas & Michael F. Murphy Part Two: Complications of Transfusions 6 Investigation of acute transfusion reactions, 65 Kathryn E. Webert & Nancy M. Heddle 7 Haemolytic transfusion reactions, 77 Edwin J. Massey, Robertson D. Davenport & Richard M. Kaufman 8 Febrile and allergic transfusion reactions, 89 Mark K. Fung & Nancy M. Heddle 9 Acute lung injury after transfusion, 97 Steven H. Kleinman & Ram Kakaiya 10 Purported adverse effects of transfusion-related immunomodulation and of the transfusion of ‘old blood’, 106 Eleftherios C. Vamvakas 11 Transfusion-associated graft-versus-host disease and microchimerism, 116 Beth H. Shaz, Richard O. Francis & Christopher D. Hillyer 12 Posttransfusion purpura, 127 Michael F. Murphy 13 Transfusion-transmitted infections, 132 Roger Y. Dodd & Susan L. Stramer 14 Bacterial contamination, 144 Sandra Ram´ýrez-Arcos & Mindy Goldman 15 Variant Creutzfeldt–Jakob disease, 152 Marc L. Turner 16 Emerging infections and transfusion safety, 161 Roger Y. Dodd Part Three: Practice in Blood Centres and Hospitals 17 Regulatory aspects of blood transfusion, 171 William G. Murphy, Louis M. Katz & Peter Flanagan 18 The role of haemovigilance in transfusion safety, 181 James P. AuBuchon & Katharine A. Downes 19 Donors and blood collection, 190 Ellen McSweeney & William G. Murphy 20 Blood donation testing and the safety of the blood supply, 201 Richard Tedder, Simon J. Stanworth & Mindy Goldman 21 Production and storage of blood components, 209 Rebecca Cardigan & Stephen Thomas 22 Medicolegal aspects of transfusion practice, 224 Patricia E. Hewitt 23 Blood transfusion in hospitals, 230 Erica M. Wood, Mark H. Yazer & Michael F. Murphy 24 Blood transfusion in a global context, 250 David J. Roberts, Alan D. Kitchen, Stephen Field, Imelda Bates & Jean Pierre Allain Part Four: Clinical Transfusion Practice 25 Inherited and acquired coagulation disorders, 263 Vickie McDonald & Samuel J. Machin 26 Massive blood loss, 276 Beverley J. Hunt & John R. Hess 27 Good blood management in acute haemorrhage and critical care, 284 Gavin J. Murphy, Nicola Curry, Nishith Patel & Timothy S. Walsh 28 Haematological disease, 300 Lise J. Estcourt, Simon J. Stanworth & Michael F. Murphy 29 Blood transfusion in the management of patients with haemoglobinopathies, 314 David C. Rees 30 Heparin-induced thrombocytopenia, 322 Andreas Greinacher & Theodore E. Warkentin 31 Immunodeficiency and immunoglobulin therapy, 335 Siraj A. Misbah 32 Fetal, neonatal and childhood transfusions, 347 Irene Roberts, Naomi Luban & Helen V. New 33 Recombinant proteins in diagnosis and therapy, 368 Marion Scott Part Five: Alternatives to Transfusion 34 Principles of patient blood management, 379 Aryeh Shander & Lawrence Tim Goodnough 35 Autologous transfusion, 390 Dafydd Thomas, Biddy Ridler & John Thompson 36 Blood substitutes, 399 David J. Roberts & Chris V. Prowse 37 Pharmacological agents and recombinant activated factor VIIa, 410 Beverley J. Hunt & Simon J. Stanworth Part Six: Cellular and Tissue Therapy and Organ Transplantation 38 Regulation and accreditation in cellular therapy, 421 Derwood H. Pamphilon & Zbigniew M. Szczepiorkowski 39 Stem cell collection and therapeutic apheresis, 433 Khaled El-Ghariani & Zbigniew M. Szczepiorkowski 40 Haemopoietic stem cell processing and storage, 443 Ronan Foley & Pamela O’Hoski 41 Haemopoietic stem cell transplantation, 455 I. Grant McQuaker & Ian M. Franklin 42 Cord blood transplantation, 464 Rachael Hough 43 Recent advances in clinical cellular immunotherapy, 473 Mark W. Lowdell & Emma Morris 44 Tissue banking, 480 Akila Chandrasekar, Paul Rooney & John Kearney Part Seven: Development of the Evidence Base for Transfusion 45 Observational and interventional trials in transfusion medicine, 491 Alan Tinmouth, Dean Fergusson & Paul C. H´ebert 46 Getting the most out of the evidence for transfusion medicine, 505 Simon J. Stanworth, Susan J. Brunskill, Carolyn Doree, Sally Hopewell & Donald M. Arnold 47 Variation in transfusion practice and how to influence clinicians’ use of blood in hospitals, 516 Simon J. Stanworth, J.J. Francis, Michael F. Murphy & Alan T. Tinmouth 48 Scanning the future of transfusion medicine, 524 Dana V. Devine, Walter H. Dzik & Zbigniew M. Szczepiorkowski Index, 537 Colour plate section can be found facing page 432

About the Author :
Professor Michael F. Murphy, Consultant Haematologist, Department of Haematology, NHS Blood & Transplant, John Radcliffe Hospital, Oxford, UK. Dr Derwood Pamphilon, Consultant Haematologist, National Blood Service, Bristol, UK. Professor Nancy Heddle, Professor of Medicine, McMaster University, Ontario, Canada; Associate Professor, Department of Medicine and Director of the McMaster Transfusion Research Program (MTRP) and the Quality Essentials for Safe Transfusion (QUEST) Hamilton-Niagara Program.