Blood and Marrow Transplantation Long-Term Management: Prevention and Complications

Currently more than 100,000 patients undergo blood and marrow transplantation (BMT) annually worldwide, a number which is steadily increasing. Long-term survival after BMT has improved significantly since its inception over 40 years ago, due to improved supportive care and early recognition of long-term complications. With broadening indications, more options for BMT, and improvement in survival, by 2020 there may be up to a million long-term survivors after BMT globally. Higher than average rates of second malignancies and cardiopulmonary, infectious, endocrine, and renal diseases, and bone loss or avascular necrosis amongst this population suggest that the rapidly swelling ranks of BMT survivors require more frequent screening and earlier interventions than the general population. The purpose of Blood and Marrow Transplantation Long-Term Management is to describe practical approaches to screening for and managing these late effects, with the goal of reducing preventable morbidity and mortality associated with BMT. This unique new book is the first to address the needs of the increasing population of long-term survivors after stem cell transplantation, making it a must-have resource for all oncologists, hematologists, and primary care physicians involved in the long-term management and care of BMT patients. Titles of related interest Thomas’ Hematopoietic Cell Transplantation, 4th edition Appelbaum, ISBN 9781405153485 Practical Stem Cell Transplantation Cant, ISBN 9781405134019 Mollison’s Blood Transfusion in Clinical Medicine, 12th edition Klein, ISBN 9781405199407

Table of Contents:
Foreword by John Barrett vii Foreword by Stephanie J Lee viii Foreword by John Goldman ix List of Contributors x Section 1 Late effects concepts 1 1 Introduction 3 Bipin N Savani 2 Overview: transplant data and increasing numbers of long-term survivors 7 Jakob R Passweg and Helen Baldomero 3 Long-term transplant clinic setup 11 André Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovó 4 Late effects after allogeneic hematopoietic stem cell transplantation 21 Shahrukh Hashmi and Mark R Litzow 5 Late effects after autologous hematopoietic stem cell transplantation 31 Sairah Ahmed and Yago Nieto 6 Graft-versus-host disease and late effects after hematopoetic stem cell transplantation 43 Gérard Socié 7 Prominent role of allied health professionals (nurse practitioners, physician assistants, others) in long-term follow-up after hematopoietic stem cell transplantation 52 Catherine E Lucid Section 2 Management, 55 8 Screening and prevention guidelines for hematopoietic cell transplant survivors 57 Navneet S Majhail and J Douglas Rizzo 9 Secondary malignancies: prevalence, screening, prevention, and management guidelines 65 Paolo F Caimi and Hillard M Lazarus 10 Cutaneous chronic graft-versus-host disease 77 Attilio Olivieri, Daniela Massi, Andrea Bacigalupo, and Anna Campanati 11 Anti-infective prophylaxis, immunization and prevention of recurrent infectious complications in long-term survivors 106 John P Galvin and Jayesh Mehta 12 Seasonal virus infections: prevention and management guidelines 116 Gaurav Trikha and John R Wingard 13 Exposure to family members: infections and recent live vaccinations 130 Brian G Engelhardt and James E Crowe, Jr 14 Late pulmonary complications after allogeneic hematopietic stem cell transplantion: bronchiolitis obliterans syndrome (BOS) and organizing pneumonia (OP) 141 Lee Gazourian, Gerald L Weinhouse, Joseph H Antin, and Vincent T Ho 15 Post-transplantation bone disease: prevalence, monitoring, prevention, and management guidelines 151 Kathryn Dahir, Brandon Perry, and Shubhada Jagasia 16 Ocular complications: prevalence, monitoring, prevention, and management guidelines 162 André Tichelli and Alicia Rovó 17 Oral complications in hematopoietic stem cell transplantation survivorship 172 Sharon Elad, Corey Cutler, and Nathaniel Treister 18 Sexual dysfunction in long-term survivors: monitoring and management 183 Andrea L Utz and Shubhada Jagasia 19 Fertility issues, contraception, and pregnancy outcome in long-term survivors 193 Alicia Rovó, Nina Salooja, Carl P Schwarze, Joerg P Halter, and André Tichelli 20 Follow-up of children after hematopoietic stem cell transplantation: growth and development 203 Kristina K Hardy, David A Jacobsohn, and Evelio Perez-Albuerne 21 Posttransplant diabetes mellitus: monitoring, prevention, and management guidelines 215 Prathima Jasti, Shichun Bao, and Shubhada Jagasia 22 Thyroid disease: monitoring and management guidelines 225 M Kathleen Figaro, Cheryl A Fassler, Shubhada Jagasia, and Vipul T Lakhani 23 Special issues related to female long-term survivors 233 Melissa A Merideth, Kristin Clay Chabarria, Tajana Klepac Pulanic, and Pamela Stratton 24 Cardiac and vascular complications in long-term survivors after hematopoietic stem cell transplantation 244 Alicia Rovó and André Tichelli 25 Hyperlipidemia: prevalence, monitoring, management, interactions with immunosuppressive agents, and follow-up 258 Dara L Eckerle Mize, Shubhada Jagasia, and Jeffrey B Boord 26 Hypertension management in long-term survivors 269 Imad Abboud 27 Gastrointestinal complications of hematopoietic cell transplantation 276 Preet Bagi, Niharika Samala, Steven Pavletic, and Theo Heller 28 Hepatic complications of hematopoietic stem cell transplantation 286 Niharika Samala, Preet Bagi, Theo Heller, and Steven Pavletic 29 Monitoring and management of hepatitis B, hepatitis C, and HIV infection before and after transplantation 294 Keith Luckett and Stephen Dummer 30 Prevention and management of renal complications in long-term survivors 304 Michael Dickenmann and Joerg P Halter 31 Immunosuppressive agents and monitoring in long-term survivors 314 Paul Shaughnessy and Helen Leather Section 3 Supportive care for long-term survivors after HSCT 321 32 Nutritional assessments and nutritional supplementation for long-term transplant survivors: multivitamins, vitamin D, calcium, antioxidants, and minerals 323 Lauren Zatarain, LaQuisa Hill, Daniel R Thomas, and Stacey A Goodman 33 Daily routines and guidelines: driving, infection isolation, masks, food/diet, activities, exercise, pets, sun exposures, and others 332 Angela M Woods 34 Caregivers of long-term survivors 340 Elizabeth Wulff-Burchfield 35 Health-related quality of life in adult and pediatric survivors of hematopoietic stem cell transplantation 345 Margaret Bevans and Lori Wiener 36 Prevalent psychosocial adjustment issues and solutions: lifestyle and social challenges 368 Katrina M Stokes 37 A patient’s perspective: concepts of long-term survivor support groups and their roles 376 Michael W Brown APPENDIX 1 NMDP/Be The Match posttransplant guidelines resources 379 Darlene Haven APPENDIX 2 Long-term follow-up calendar 381 André Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovó APPENDIX 3 Commonly used transplant-related medications in long-term survivors 385 Melissa Logue Index, 387