Inflammatory Diseases of Blood Vessels

In recent years, considerable progress has been made in understanding the vasculitic diseases, largely due to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in this new edition, which is designed to provide a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.

Table of Contents:
List of Contributors Preface Section I. Biology of Blood Vessels and Mechanisms of Vascular Inflammation 1 Vascular Development Domenico Ribatti and Enrico Crivellato 2 Vascular Repair Christian Troidl, Kerstin Troidl, Georg Jung, Thomas Schmitz-Rixen and Wolfgang Schaper 3 Leukocyte Trafficking Braedon McDonald and Paul Kubes 4 Dendritic Cells and Vascular Inflammation Cornelia M. Weyand 5 T Cells and Vascular Inflammation Jorg J. Goronzy 6 Autoantibodies and Vascular Inflammation A.Rutgers, J.S.F. Sanders, J.W. Cohen Tervaert, C.G.M. Kallenberg 7 Neutrophils and Vascular Inflammation Matthew David Morgan and Caroline OS Savage 8 Cytokines and Vascular Inflammation Maria C Cid, Marc Corbera-Bellalta, Ester Planas-Rigol, Ester Lozano, Georgina Espigol-Frigole, Ana Garcia-Martinez, Jose Hernandez-Rodriguez, Marta Segarra 9 Oxidative Stress and Vascular Inflammation David G. Harrison 10 Hemostasis and Vascular Inflammation Lawrence Leung and John Morser 11 Animal Models of Vasculitis Masato Nose 12 Arteries, Smooth Muscle Cells, and Genetic Causes of Thoracic Aortic Aneurysms Amy J. Reid and Dianna M. Milewicz 13 Innate Immunity in Atherosclerosis Shuang Chen, Prediman K. Shah and Moshe Arditi 14 Adaptive Immunity in Atherosclerosis Jan Nilsson Section II. Primary Autoimmune Vascular Diseases 15 Historical Perspectives Vasculitis Eric L. Matteson 16 Approach to the Differential Diagnosis of Vasculitis Eamonn S. Molloy and Carol A. Langford 17 Imaging of medium and large vessels (CT/PET/MR) Thorsten Alexander Bley 18 Kawasaki disease Rae S.M. Yeung 19 Henoch-Schonlein Purpura Philip J. Hashkes and Alexandra Villa-Forte 20 Polyarteritis Nodosa Eli M. Miloslavsky and John H. Stone 21 Microscopic polyangiitis Coen Stegeman 22 Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Gary S. Hoffman, Carol A. Langford and Ulrich Specks 23 Churg-Strauss Syndrome (Eosinophilic Granulomatosis with Polyangiitis, EGPA) Christian Pagnoux and Loic Guillevin 24 Giant cell arteritis Cornelia M. Weyand and Jorg J. Goronzy 25 Takayasu's arteritis Kathleen Maksimowicz-McKinnon and Gary S. Hoffman 26 Behcet's Syndrome Yusuf Yazici, Ismail Simsek and Hasan Yazici 27 Cogan's Syndrome Rex M. McCallum and E. William St. Clair 28 Idiopathic cryoglobulinemic vasculitides Benjamin Terrier and Patrice Cacoub 29 Primary central nervous system vasculitis Rula A. Hajj-Ali and Leonard H. Calabrese 30 Single organ vasculitis Jose Hernandez-Rodriguez and Gary S. Hoffman 31 Primary cutaneous vasculitis Jeffrey P. Callen 32 Buerger's disease (thromboangiitis obliterans) Ahmet Ruchan Akar and M. Serkan Durdu Section III. Secondary Causes of Vasculitis 33 Virus-associated vasculitides Dimitrios Vassilopoulos and Leonard H. Calabrese 34 Drug-induced vasculitis Peter A. Merkel 35 Rheumatoid vasculitis Kimberly P. Liang, Carl Turesson, Larry W. Moreland 36 Vasculopathy/Vasculitis and progressive systemic sclerosis Nezam Altorok, Omar R. Kahaly and Bashar Kahaleh 37 Vasculitis and Sjogren's syndrome George E. Fragoulis and Haralampos M. Moutsopoulos 38 Vasculitis in systemic lupus erythematosus Ricardo Garcia and Andras Perl 39 Vasculitis in the Idiopathic Inflammatory Myopathies Frederick W. Miller and Chester V. Oddis 40 Vasculitis and relapsing polychondritis Tanaz A. Kermani and Kenneth J. Warrington 41 Systemic Vasculitis in Sarcoidosis Alexandra Villa-Forte and Gary S. Hoffman 42 Vasculitis as a Paraneoplastic Syndrome and Direct Tumour Invasion of Vessels Claire E. Barber and Simon Carette Section IV. Recognizing Risks and Treating Damage from Vasculitis 43 Cholesterol and Modifications of Cholesterol in Rheumatic Disorders Jan Willem Cohen Tervaert 44 Prevention and treatment of medical complications Atul Khasnis and Carol A. Langford 45 Ophthalmic Risks and Complications Aassociated with the Treatment of Systemic Vasculitis Steven Yeh and James T. Rosenbaum 46 Subglottic Stenosis of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Rahul Seth and Daniel S. Alam 47 Sino-Nasal Manifestations of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Daniel S. Alam, Rahul Seth, Raj Sindwani 48 Neurologic Damage of Vasculitis C. David Lin 49 Endstage Renal Disease and Vasculitis Kirsten de Groot and Charles Pusey 50 Cardiothoracic Surgery for Takayasu's Arteritis and Giant Cell Arteritis Turki Albacker and Lars Svensson 51 Peripheral Vascular Surgery for Takayasu's Arteritis and Giant Cell Arteritis Ravi R. Rajani and Vikram S. Kashyap Index

About the Author :

Edited by

Gary S. Hoffman MD, MS
Professor of Medicine Department of Rheumatic and Immunologic Diseases Center for Vasculitis Care and Research Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA

Cornelia M. Weyand MD, PhD
Professor of Medicine Stanford University School of Medicine Stanford, CA, USA

Carol A. Langford MD, MHS
Director, Center for Vasculitis Care and Research Department of Rheumatic and Immunologic Diseases Cleveland Clinic Lerner College of Medicine Cleveland, OH, USA

Jörg J. Goronzy MD, PhD
Professor of Medicine Stanford University School of Medicine Stanford, CA, USA