Success Probability Estimation with Applications to Clinical Trials
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Medicine: general issues > Public health and preventive medicine > Epidemiology and Medical statistics > Success Probability Estimation with Applications to Clinical Trials
10%
Success Probability Estimation with Applications to Clinical Trials

Success Probability Estimation with Applications to Clinical Trials


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

Provides an introduction to the various statistical techniques involved in medical research and drug development with a focus on estimating the success probability of an experiment Success Probability Estimation with Applications to Clinical Trials details the use of success probability estimation in both the planning and analyzing of clinical trials and in widely used statistical tests. Devoted to both statisticians and non-statisticians who are involved in clinical trials, Part I of the book presents new concepts related to success probability estimation and their usefulness in clinical trials, and each section begins with a non-technical explanation of the presented concepts. Part II delves deeper into the techniques for success probability estimation and features applications to both reproducibility probability estimation and conservative sample size estimation. Success Probability Estimation with Applications to Clinical Trials: • Addresses the theoretical and practical aspects of the topic and introduces new and promising techniques in the statistical and pharmaceutical industries Features practical solutions for problems that are often encountered in clinical trials Includes success probability estimation for widely used statistical tests, such as parametric and nonparametric models Focuses on experimental planning, specifically the sample size of clinical trials using phase II results and data for planning phase III trials Introduces statistical concepts related to success probability estimation and their usefulness in clinical trials Success Probability Estimation with Applications to Clinical Trials is an ideal reference for statisticians and biostatisticians in the pharmaceutical industry as well as researchers and practitioners in medical centers who are actively involved in health policy, clinical research, and the design and evaluation of clinical trials.

Table of Contents:
Preface xv Acknowledgments xvii Acronyms xix Introduction xxi I.1 Overview of clinical trials xxii I.2 Success rates of clinical trials xxiv I.3 Success probability xxv I.4 Starting from practice xxvii PART I SUCCESS PROBABILITY ESTIMATION IN PLANNING AND ANALYZING CLINICAL TRIALS 1 Basic statistical tools 3 1.1 Pointwise estimation 4 1.2 Confidence interval estimation, conservative estimation 6 1.3 The statistical hypotheses, the statistical test and the type I error for one-tailed tests 10 1.4 The power function and the type II error 11 1.5 The p-value 14 1.6 The success probability and its estimation 17 1.7 Basic statistical tools for two tailed tests 19 1.8 Other statistical hypotheses and tests 23 2 Reproducibility Probability Estimation 25 2.1 Pointwise RP estimation 26 2.2 RP-testing 29 2.3 The RP estimate and the p-value 32 2.4 Statistical lower bounds for the RP 35 2.5 The stability criterion for statistical significance 37 2.6 Other stability criteria for statistical significance 40 2.7 Comparing stability criteria 43 2.8 Regulatory agencies and the single study 45 2.9 The RP for two-tailed tests 46 2.10 Discussing Situation I in Section I.4.1 49 3 Sample Size Estimation 51 3.1 The classical paradigm of sample size determination 52 3.2 SP estimation for adapting the sample size 55 3.3 Launching the trial in practice 57 3.4 Practical aspects of SSE 60 3.5 Frequentist conservative SSE 67 3.6 Optimal frequentist CSSE 70 3.7 Bayesian CSSE 75 3.8 A comparison of CSSE strategies 80 3.9 Discussing Situations I and II in Section I.4 83 3.10 Sample size estimation for the two-tailed setting 85 4 Robustness and Corrections in Sample Size Estimation 89 4.1 CSSE strategies with different effect sizes in phases II and III 90 4.2 Comparing CSSE strategies in different Scenarios 91 4.3 Corrections for CSSE strategies 94 4.4 A comparison among Corrected CSSE strategies 97 PART II SUCCESS PROBABILITY ESTIMATION FOR SOME WIDELY USED STATISTICAL TESTS 5 General parametric SP estimation 105 5.1 The parametric model 105 5.2 Power, SP and noncentrality parameter estimation 106 5.3 RP estimation and testing 107 5.4 Sample size estimation 108 5.5 Statistical tests included in the model 109 6 SP estimation for Student’s t statistical tests 113 6.1 Test for two means equal variances 114 6.1.1 Power and RP estimation 114 6.2 Test for two means unequal variances 117 6.3 On Student’s t RP estimates 120 7 SP estimation for Gaussian distributed test statistics 123 7.1 Test for two proportions 123 7.2 Test for survival: the log-rank test 127 8 SP estimation for Chi-square statistical tests 133 8.1 Test for two multinomial distributions: 2 x C comparative trial 133 8.2 Test for S couples of binomial distributions: the Mantel-Haenszel test 137 8.3 On χ2 RP estimates 141 9 General nonparametric SP estimation with - applications to the Wilcoxon test 143 9.1 The nonparametric model 144 9.2 General nonparametric SP estimation 145 9.3 The Wilcoxon rank-sum test 146 A Tables of quantiles 161 B Tables of RP estimates for the one-tailed Z test 169 References 179 Topic index 185 Author index 193

About the Author :
DANIELE DE MARTINI, PhD, is Assistant Professor in the Department of Statistics and Quantitative Methods at the University of Milano-Bicocca in Italy. He is also a member of the American Statistical Association, Society for Clinical Trials, and Italian Statistical Society.


Best Sellers


Product Details
  • ISBN-13: 9781118335789
  • Publisher: John Wiley & Sons Inc
  • Publisher Imprint: John Wiley & Sons Inc
  • Height: 244 mm
  • No of Pages: 232
  • Returnable: N
  • Weight: 454 gr
  • ISBN-10: 1118335783
  • Publisher Date: 17 May 2013
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Spine Width: 18 mm
  • Width: 163 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Success Probability Estimation with Applications to Clinical Trials
John Wiley & Sons Inc -
Success Probability Estimation with Applications to Clinical Trials
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Success Probability Estimation with Applications to Clinical Trials

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!