Human Population Genetics: (7 Foundation of Human Biology)

Introductory guide to human population genetics and microevolutionary theory Providing an introduction to mathematical population genetics, Human Population Genetics gives basic background on the mechanisms of human microevolution. This text combines mathematics, biology, and anthropology and is best suited for advanced undergraduate and graduate study. Thorough and accessible, Human Population Genetics presents concepts and methods of population genetics specific to human population study, utilizing uncomplicated mathematics like high school algebra and basic concepts of probability to explain theories central to the field. By describing changes in the frequency of genetic variants from one generation to the next, this book hones in on the mathematical basis of evolutionary theory. Human Population Genetics includes: Helpful formulae for learning ease Graphs and analogies that make basic points and relate the evolutionary process to mathematical ideas Glossary terms marked in boldface within the book the first time they appear In-text citations that act as reference points for further research Exemplary case studies Topics such as Hardy-Weinberg equilibrium, inbreeding, mutation, genetic drift, natural selection, and gene flow Human Population Genetics solidifies knowledge learned in introductory biological anthropology or biology courses and makes it applicable to genetic study. NOTE: errata for the first edition can be found at the author's website: http://employees.oneonta.edu/relethjh/HPG/errata.pdf

Table of Contents:
Foreword vii Preface ix 1 GENETIC, MATHEMATICAL, AND ANTHROPOLOGICAL BACKGROUND 1 I. The Scope of Population Genetics 2 II. Genetics Background 5 III. Principles of Probability 14 IV. The Anthropological Connection 17 V. A Closing Thought 21 2 HARDY–WEINBERG EQUILIBRIUM 23 I. Genotype and Allele Frequencies 24 II. What is Hardy–Weinberg Equilibrium? 30 III. The Mathematics of Hardy–Weinberg Equilibrium 31 IV. Using Hardy–Weinberg Equilibrium 37 V. Extensions of Hardy–Weinberg Equilibrium 40 VI. Hardy–Weinberg Equilibrium and Evolution 44 VII. Summary 45 3 INBREEDING 49 I. Quantifying Inbreeding 51 II. Population Genetics and Inbreeding 62 III. Inbreeding in Human Populations 65 IV. Summary 75 4 MUTATION 77 I. The Nature of Mutations 77 II. Models of Mutation 81 III. Mutational History and Anthropological Questions 88 IV. Summary 96 5 GENETIC DRIFT 101 I. What is Genetic Drift? 102 II. Genetic Drift and Population Size 112 III. Effects on Genetic Variation 120 IV. Mutation and Genetic Drift 121 V. Coalescent Theory 125 VI. Summary 131 6 MODELS OF NATURAL SELECTION 139 I. How Does Natural Selection Work? 140 II. A General Model of Natural Selection 145 III. Types of Natural Selection 147 IV. Other Aspects of Selection 160 V. Summary 167 7 NATURAL SELECTION IN HUMAN POPULATIONS 181 I. Case Studies of Natural Selection in Human Populations 182 II. Are Humans Still Evolving? 198 III. Summary 203 8 GENE FLOW 205 I. The Evolutionary Impact of Gene Flow 206 II. Models of Gene Flow 208 III. Gene Flow and Genetic Drift 213 IV. Estimating Admixture in Human Populations 226 V. Summary 230 9 HUMAN POPULATION STRUCTURE AND HISTORY 237 I. Case Studies of Human Population Structure 238 II. The Origin of Modern Humans 242 III. Case Studies of Population Origins 247 IV. Summary 255 Glossary 257 References 267 Index 279

About the Author :
Dr. John H. Relethford (Distinguished Teaching Professor) is a biological anthropologist who received his Ph.D. in anthropology in 1980 from the State University of New York at Albany. Dr. Relethford's major interests are in the fields of anthropological genetics, human variation, and modern human origins. Much of his research has focused on the reconstruction of history from patterns of modern biological variation. His past work has also included studies of migration, quantitative genetics, child growth, epidemiology, and aging. His current work focuses on two topics, the evolutionary history of Irish populations and the origin of modern humans.

Review :
“Relethford’s Human Population Geneticsis a superb attempt at facing the challenges of explaining the basics of population genetics to those with a limited background in evolutionary theory and a fear of the quantitative.”  (The Quarterly Review of Biology, 1  September 2014) “For many students, and likely some instructors, who have found the mathematical underpinnings of evolutionary genetics daunting, this new volume will be a welcome addition to the bookshelf. It is an easy book to recommend either as a primary text in anthropological genetics courses, or as a recommended or adjunct text in upper division/beginning graduate courses in human biology, human genetics, or human evolution.”  (American Journal of Physical Anthropology, 19 September 2013)