Managing Myeloproliferative Neoplasms: A Case-Based Approach

This is a concise, practical, case-based book documenting examples and scenarios that will help you manage challenging clinical issues for patients with myeloproliferative neoplasms. The editors and authors have strived to distil the very latest information in this rapidly advancing field in a way that will help you to update your practice and manage your patients. The key focuses are: diagnosis, both standard and challenging; both day-to-day management as well as special situations such as surgery, thrombotic events and pregnancy; and finally, managing evolving situations with MPN such as progression to acute myeloid leukemia. This book is an outstanding resource that includes a discussion of both classical myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera and myelofibrosis, and also less common disorders such as systemic mast cell disease, hypereosinophilia, MPN/MBS overlap syndromes and atypical CML, amongst others. This book is a practical reference for practitioners, hematologists, medical oncologists and trainees.

Table of Contents:
Preface; 1. Initial assessment of the undiagnosed patient who has an erythrocytosis, leucocytosis or thrombocytosis Mary Frances McMullin; 2. Practical approaches to molecular testing and diagnosis of mastocytosis, hypereosinophilia and MDS/MPN overlap syndromes Nicholas C. P. Cross, Dimitra Koumaki, Georgia Metzgeroth and Andreas Reiter; 3. Incidental splenomegaly: an approach to diagnosis Craig B. Reeder; 4. When to do a bone marrow biopsy and how to interpret it in the diagnosis of myeloproliferative neoplasm Hans Michael Kvasnicka; 5. Accurately assessing risk in your myeloproliferative neoplasm patient Francisco Cervantes and Arturo Pereira; 6. Incorporating symptomatic assessment in therapy choice for patients with myeloproliferative neoplasms Robyn M. Scherber, Holly L. Geyer and Ruben A. Mesa; 7. The newly diagnosed patient with essential thrombocythemia Guido Finazzi; 8. The newly diagnosed patient with polycythemia vera Alessandro M. Vannucchi and Paola Guglielmelli; 9. Longstanding polycythemia vera and essential thrombocythemia: monitoring and management goals Loula Papageorgiou and Claire Harrison; 10. Management of myelofibrosis: which patients are candidates for JAK inhibitors and how to manage patients on JAK inhibitor treatment Lorenzo Falchi and Srdan Verstovsek; 11. Hematopoietic cell transplantation for myelofibrosis: who and when? Veena Fauble and Vikas Gupta; 12. Systemic mast cell disease, diagnosis and management Deepti Radia; 13. Hypereosinophilia: an illustrated approach to diagnosis and management Jason Gotlib; 14. Myelodysplastic/myeloproliferative neoplasm overlap syndromes Aaron T. Gerds, Ramon V. Tiu and Mikkael A. Sekeres; 15. Atypical chronic myeloid leukemia and chronic neutrophilic leukemia Daniel A. Pollyea and Jeffrey T. Schowinsky; 16. Women and children with myeloproliferative neoplasms – special considerations Robert Schneidewend and Laura C. Michaelis; 17. Conception and pregnancy in myeloproliferative neoplasms Susan Robinson; 18. Managing acute vascular events in patients with myeloproliferative neoplasms David Garcia and Bethany T. Samuelson; 19. Challenging thrombotic scenarios in the myeloproliferative neoplasms: splanchnic vein thrombosis and others Brady L. Stein; 20. Familial myeloproliferative neoplasms – implications for patients and their families Sabina Swierczek and Josef Prchal; 21. Management of acute leukemia following myeloproliferative neoplasms Raoul Tibes; Index.