Neurodegeneration: Molecular Basis of Treatment Approaches

Neurodegeneration, the progressive loss of structure and function of neurons in the body, is a condition that affects millions of people globally. This new book covers the basics of neurodegeneration as well as the etiology, epidemiology, and diagnostics of neurodegenerative illnesses in depth. A thorough discussion of the molecular mechanisms behind neurodegenerative illnesses is provided, with particular emphasis on the roles that protein folding and misfolding play in the onset and progression of these conditions. Recent advancements in neurodegeneration associated with brain iron buildup, oxidative stress, and biomarker research are also covered. Repurposed medications, approved treatment approaches for neurodegenerative illnesses, and the application of AI and machine learning for diagnosis and therapy are all discussed. Along with cutting-edge CRISPR/Cas and genetic techniques, the book also emphasizes the potential of ethnomedicinal contributions toward neurodegenerative illnesses.

Table of Contents:
1. Introduction to Neurodegeneration: Molecular Basis of Treatment Approaches 2. Neurodegeneration: Etiology, Epidemiology, Diagnosis 3. Molecular Mechanisms of Neurodegenerative Diseases 4. Protein Folding and Misfolding in Neurodegenerative Diseases 5. Biomarkers Studies in Neurodegenerative Disease 6. Oxidative Stress in Neurodegeneration: Cause or Consequence? 7. Neurodegeneration with Brain Iron Accumulation 8. Approved Treatment Strategies for Neurodegenerative Diseases 9. Unlocking the Potential: Repurposing Drugs for Neurodegeneration 10. Use of AI/ML for Diagnosis and Treatment 11. Ethnomedical Contributions Toward Neurodegenerative Diseases 12. Advanced CRISPR-Cas and Genetic Approaches for Neurodegeneration 13. Challenges and Future Prospects in Diagnosis and Treatment of Neurodegenerative Diseases

About the Author :
Vivek P. Chavda, MPharm, is an Assistant Professor in the Department of Pharmaceutics and Pharmaceutical Technology at L. M. College of Pharmacy, India. Before joining academia, he worked in the biologics industry in research and development, contributing to regulatory filings at Lupin Biotech and Dr. Reddy's Laboratories. He has more than 200 publications to his credit. He is listed among the world's top 2% of scientists by Stanford University and Elsevier. His interests include biologics process and formulation development, medical device development, nano-diagnostics, non-carrier formulations, long-acting parenteral formulations, and nano-vaccines. Rajashri Bezbaruah, MPharm, is a Lecturer at the Institute of Pharmacy, Assam Medical College and Hospital, India. She was formerly affiliated with the Pratiksha Institute of Pharmaceutical Sciences and the Department of Pharmaceutical Sciences at Dibrugarh University, India. To her credit, she has more than 18 national and international publications, five book chapters, and eight articles in progress. Her research interests include immunological studies, evaluation of herbal neuroprotective drugs, and extraction and isolation of herbal drugs. Bibhuti Bhushan Kakoti, PhD, is a Professor of Pharmaceutical Sciences at Dibrugarh University, India, where he is also the in-charge for the Centre of Studies in Biotechnology, scientist in-charge of the Institutional Animal Ethical Committee, and member of various boards. He has guided more than 20 PhD scholars and has published more than 40 national and international articles and book chapters. His research interests include screening and evaluation of plants and synthetic drugs. Vladimir N. Uversky, PhD, DSc, FRSB, FRSC, is a Professor in the Department of Molecular Biology, University of South Florida, USA. He has authored over 1150 scientific publications and has been included on the Clarivate List of Highly Cited Researchers™ from 2014 to 2020. He is a Fellow of the Royal Society of Biology and a Fellow of the Royal Society of Chemistry. He has delivered more than 240 invited talks and seminars around the globe and has collaborated with more than 12,500 colleagues from more than 2,750 research organizations in 89 countries/territories. He is an editor of a number of scientific journals and has edited several books and book series on protein structure, function, folding, and misfolding.