Usefulness of Acute Phase Reactant Score in the Neonatal Period
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Usefulness of Acute Phase Reactant Score in the Neonatal Period: Managing Neonatal Infections

Usefulness of Acute Phase Reactant Score in the Neonatal Period: Managing Neonatal Infections


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About the Book

In clinical practice, the most important points for accurately diagnosing neonatal infections are: immediate results at the bedside (quickness), accuracy of results (reliability), the degree of invasiveness to the sick baby is as low as possible (less invasiveness), the examination is not too expensive (cost performance), and the examination can be repeated (repeatability). This book describes the acute phase reactant (APR) score, in which one test item is 10 µL, and three APRs can be measured within 3 minutes in total at the bedside and scored. With clinicians' keen observability and this APR score, neonatal infections can be confidently assessed. In addition, this book does not only refer to APR score, but also publishes the measurement results of cytokine profiles in comparison with APR scores throughout. This book will also increase understanding of the pathophysiology of neonatal infectious diseases.

About the Author :
Toshihiko Nakamura, MD, PhD, is a clinical professor at Tokyo Medical and Dental University, Japan, and Director of Neonatology at the Japanese Red Cross Musashino Hospital in Tokyo. He is the author of "Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury induced by the intratracheal instillation of endotoxin in piglets" in the Journal of Neonatal Biology (2001), "Study on the Usefulness of APR Scores from the Viewpoint of Proinflammatory Cytokines" in Disease Markers (2015), and "The mechanism of onset in neonatal leukemoid reaction: synergistic effects of proinflammatory cytokines including interleukin-6" in Advances in Medicine and Biology (2020).Haruo Goto, MD, PhD, is Honorary Director of Nagoya City University West Medical Center, Japan. He is the author of "Diagnostic significance of serum orosomucoid level in bacterial infection during neonatal period" in Acta Paediatrica Scandinavica (1973), and "Evaluation of APR-Score (acute-phase reactants score) as screening test of the neonatal infection." in Acta Neonatologica Japonica (1974).

Review :
'This book integrates evidence of APR score efficacy in neonatal medicine. With a dream that no neonate will die of infection, Dr Goto (one of the authors of this book) developed the APR score, a prompt infection diagnostic method that uses a small sample volume. In many NICUs in Japan, this score has been proven useful, not only for diagnosis of infection, but also for the evaluation of inflammatory status. One author, Dr Nakamura, is an excellent neonatologist who has aspired to disseminate APR score across the globe.'Norihisa Koyama, MD, PhDDoctor at Toyohashi Children's Mental and Physical Development Center, Japan, and Former Vice-Director of Toyohashi Municipal Hospital, Japan'This book provides a detailed description of APR as well as other inflammation-related cytokines in the unique pathology of preterm infants and rare case reports, making it easy to understand the pathology.'Tanaka Taihei, MD, PhDFormer Director of the Department of Neonatology at the Japanese Red Cross Society Nagoya Daini Hospital, Japan'Dr Nakamura and Professor Goto have developed the APR Score and have been making a great contribution to rescuing many neonates from infectious diseases in Japan. The neonatal survival rate of Japan is the best in the world, and I am very happy to know that this secret Score will be introduced to other countries in detail through this book.'Naoto Takahashi, MD, PhDDepartment of Pediatric and Neonatal Intensive Care, University of Tokyo, Japan'This book is well-written, and the readers will find it full of clinical pearls. I highly recommend this book to all neonatologists worldwide. Starting with the history and principles of the APR test, the book details its usefulness in diagnosing infectious diseases and its application in inflammatory diseases and other neonatal-specific conditions, with examples. This is a useful book to refer to at the bedside.'Tomohiro Morio, MD, PhDDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU) Graduate School, Japan


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Product Details
  • ISBN-13: 9781036400132
  • Publisher: Cambridge Scholars Publishing
  • Publisher Imprint: Cambridge Scholars Publishing
  • Edition: Unabridged edition
  • Language: English
  • Sub Title: Managing Neonatal Infections
  • ISBN-10: 1036400131
  • Publisher Date: 29 Feb 2024
  • Binding: Hardback
  • Height: 212 mm
  • No of Pages: 250
  • Width: 148 mm


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Usefulness of Acute Phase Reactant Score in the Neonatal Period: Managing Neonatal Infections
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