Fimbriae Adhesion, Genetics, Biogenesis, and Vaccines

Fimbriae are the best-studied bacterial colonization factors. They are of paramount importance in bacterial pathogenesis and microbial ecology. Due to the advent of new and powerful techniques, an impressive amount of information has been accumulated on these important surface organelles over the last decade. The first book of its kind, Fimbriae brings together into one volume the state of the art of this very active field. Internationally recognized researchers give both a horizontal and lateral approach to fimbriology. Selected types of fimbriae are extensively reviewed and fundamental questions such as evolution, control or regulation, biogenesis, bacteria-host interaction, and fimbriae-based vaccines are examined.

Table of Contents:
Introduction: A Historical Perspective /James P. Duguid and David C. Old. -- Chapter 1 -- Type 1 Fimbriae of Escherichia coli /Per Klemm and Karen Angeliki Krogfelt -- Chapter 2 -- S and F1C Fimbriae /Jorg Hacker and Joachim Morschhauser -- Chapter 3 -- Structure, Function, and Biogenesis of Escherichia coli P Pili /Meta J. Kuehn, David Haslam, Staffan Normark, and Scott J. Hultgren -- Chapter 4 -- Fimbriae of Enterotoxigenic Escherichia coli /Frits K. de Graaf and Wim Gaastra -- Chapter 5 -- Nonfimbrial Adhesins of Escherichia coli /M Alexander Schmidt -- Chapter 6 -- Type 3 Fimbriae of the Enterobacteriaceae /Steven Clegg, Timo K. Korhonen, Douglas B. Homick, and Ann-Mari Tarkkanen -- Chapter 7 -- Salmonella Fimbriae /Steven Clegg and Dana L. Swenson -- Chapter 8 -- Bordetella pertussis Fimbriae /Frits R. Mooi -- Chapter 9 -- Type 4 Fimbriae /Jan M. Tennent and John S. Mattick -- Chapter 10 -- Pili (Fimbriae) of Neisseria gonorrhoeae /John K. Davies, J. Michael Koomey, and H. Steven Seifert -- Chapter 11 -- Fimbriae of Vibrio cholerae /Melissa R. Kaufman and Ronald K. Taylor -- Chapter 12 -- Regulation of E. coli Fimbrial Expression /Bernt Eric Uhlin -- Chapter 13 -- Fimbrial Operons and Evolution /Johannes G. Kusters and Wim Gaastra -- Chapter 14 -- Bacteria-Extracellular Matrix Interactions /David L. Hasty, Harry SCourtney, Evgeni V. Sokurenko, and Itzhak Ofek -- Chapter 15 -- The Role of Interactions Between Fimbriae and the Intestinal Mucus Layer in Bacterial Colonization and Enteric Pathogenesis /Paul S. Cohen and David C. Laux -- Chapter 16 -- An Ecological Perspective of Fimbrial Function in the Porcine Digestive Tract /Patricia L. Conway and Lena Blomberg -- Chapter 17 -- Fimbriae and Disease /Catharina Svanborg, Frits Orskov, and Ida Qrskov -- Chapter 18 -- Fimbrial Vaccines /Myron M Levine, Jorge A. Giron, and Fernando R. Noriega -- Chapter 19 -- Chimeric Fimbrial Vaccines /Lars Pallesen and Per Klemm -- Index.

About the Author :
Per Klemm, Ph.D., D.Sc., is Professor at the Department of Microbiology, Technical University of Denmark, located outside Copenhagen. Dr. Klemm graduated in 1976 from the University of Copenhagen, with a M.Sc. degree in biochemistry, and he obtained his Ph.D. in 1979. In 1986, he received a D.Sc. degree from the University of Copenhagen. After doing post-doctoral work at the Department of Biochemical Genetics, University of Copenhagen, and at the Max-Planck Institute for Immunobiology in Freiburg, Germany, he was appointed an Assistant Professor of Microbiology at the Technical University of Denmark in 1982. He became Associate Professor of Microbiology in 1983 and Professor in 1988. Dr. Klemm has been the recipient of research grants from the Danish Research Councils, The Carlsberg Foundation, and the World Health Organization. He has published more than 50 research papers and reviews and has presented numerous invited lectures at international meetings and universities. His current major research interests include molecular biology of fimbriae and vaccine development.