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Benign to Malignant Progression in Cervical Squamous Epithelium

Benign to Malignant Progression in Cervical Squamous Epithelium


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About the Book

This monograph is a diagnostic guide providing histologic and cytologic criteria to help the reader recognize progressive benign to malignant changes in the cervical squamous epithelium. It demonstrates the importance of retaining basic morphologic criteria in a changing scene of lesion classification with emphasis on papillomavirus, pitfalls and shades of grey. It also discusses the impact of colposcopy in concert with simplified nomenclature in the 1988 Bethesda system. The text includes a chapter on papillomavirus infection of the cervix that not only demonstrates the morphologic interplay of papillomavirus effect and dysplasia, but also puts the value of immunologic testing in cervical diagnoses in perspective.

Table of Contents:
Part 1 Setting the Stage: Basic Morphology and Cytology of the Uterine Cervix; The Transitional Zone; The Healing of Erosions by Squamous Epithelium; Two Benign Epithelial Pitfalls. Part 2 Intraepithelial Precursors to Invasive Squamous Cell Carcinoma: Historical Perspective; HPV Effect; Dysplasia and CIS - Definitions and Criteria; Classification Systems to be Evaluated and Reconciled - The Dysplasia/CIS System, The Reagan System, The CIN System, The Bethesda System; Problems and Pitfalls in Diagnosis - Shades of Gray; Summary and Review of Diagnostic Criteria. Part 3 Human Papillomavirus (HPV) Infection - Its Importance, Morphologic Expression, Relevance to Neoplasia and Methods of Viral Detection and Typing, Gerard J. Nuovo: Molecular Hybridization Analysis for HPV; Morphological Expression of HPV Infection. Part 4 Early Stromal Invasion: The Meaning of "Differentiation"; Keratinizing Lesions that Warn of Invasion; CIS with Atypical Differentiation; Another Warning of Impending Invasion - Micronucleoli; The Cytologic Recognition of Early Stromal Invasion; Controversies over Depth and Vascular Space Invasion. Part 5 Invasive Squamous Cell Carcinoma: Morphologic Criteria of Invasive Carcinoma; Histology and Classification of Squamous Cell Carcinomas; Diagnostic Pitfalls; Detection of Cancer in the Endocervical Canal; Radiation Effect. Part 6. Adenocarcinoma and Its Precursors: Adenocarcinoma in Situ (AIS) and Microinvasive Adenocarcinoma; Invasive Adenocarcinoma of the Cervix. Part 7 Problems with Biopsies and Smears: The Inadequate Cervical Biopsy and the False Negative Report; The Inadequate Pap Smear. (Part contents).


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Product Details
  • ISBN-13: 9780896402416
  • Publisher: Igaku-Shoin Medical Publishers Ltd
  • Publisher Imprint: Igaku-Shoin
  • Edition: Illustrated edition
  • Weight: 910 gr
  • ISBN-10: 089640241X
  • Publisher Date: 01 Jan 1994
  • Binding: Hardback
  • Height: 250 mm


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