About the Book
Leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer and its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth and progression has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.
Table of Contents:
Part I. Introduction. Building the Road to Defeat Prostate Cancer: A Dedication to Donald S. Coffey, W. Steven Ward. Part II. Cancer Genetics. Hereditary Prostate Cancer, William B. Isaacs, Jianfeng Xu, and Patrick C. Walsh. AR Gene Alterations in Prostate Cancer Progression, Tapio Visakorpi. Lethal Metastatic Human Prostate Cancer: Autopsy Studies and Characteristics of Metastases, G. Steven Bova, Kirk M. Chan-Tack, and William W. LeCates. Tumor Suppressor Genes in Prostate Cancer, Robert Bookstein. Androgen Receptor Polymorphisms and Prostate Cancer Risk, Phillip G. Febbo and Philip W. Kantoff. The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease, Ronald K. Ross, Juergen K. V. Reichardt, Sue Ann Ingles, and Gerhard A. Coetzee. Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques, Junqi Qian and Robert B. Jenkins. Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN), Paul H. Duray, David K. Ornstein, Cathy D. Vocke, Stephen M. Hewitt, Kristina A. Cole, John W. Gillespie, Chad R. Englert, Emanuel F. Petricoin, David B. Krizman, W. Marston Linehan, and Michael R. Emmert-Buck. Xenograft Models and the Molecular Biology of Human Prostate Cancer, Robert E. Reiter and Charles L. Sawyers. Comprehensive Analyses of Prostate Gene Expression, Peter S. Nelson. Part III. Cancer Biology. The Role of Nuclear Matrix and Cytoskeleton in Cancer, Robert H. Getzenberg. The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis, Jer-Tsong Hsieh. Ligand Dependent and Independent Activation of Androgen Receptor, Gloria R. Mora and Donald J. Tindall. Tyrosine Kinases and Cellular Signaling in Prostate Cancer, Hsing-Jien Kung, Clifford G. Tepper, and Ralph W. deVere White. Molecular Pathways that Underlie Prostate Cancer Progression: The Role of Caveolin-1, Timothy C. Thompson, Terry L. Timme, Likun Li, Chengzen Ren, Alexi Goltsov, Salahaldin Tahir, and Guang Yang. Angiogenesis and Prostate Cancer, Ingrid B. J. K. Joseph and John T. Isaacs. Prostate Specific Membrane Antigen, Denise S. O'Keefe, Dean J. Bacich, and Warren W. D. Heston. Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer, Martin E. Gleave, Hideaki Miyake, Colleen Nelson, Paul Rennie, and Simon Leung. Stromal-Epithelial Interaction: From Bench to Bedside, Leland W. K. Chung and Haiyen E. Zhau. Part IV. Cancer Therapeutics. Chemoprevention of Prostate Cancer, James D. Brooks and William G. Nelson. Anatomic Radical Retropubic Prostatectomy for Prostate Cancer, Misop Han and Alan W. Partin. Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical, and Biologic Considerations, Naren R. Ramakrishna and Theodore L. DeWeese. Prostate Cancer Chemotherapy: Closing Out a Century and Opening a New One, Jeffrey M. Kamradt and Kenneth J. Pienta. The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer, Joel B. Nelson. Development of Dendritic Cell-Based Prostate Cancer Vaccine, Benjamin A. Tjoa and Gerald P. Murphy. Antiprogression Agents for Prostate Cancer, Hadley M. Wood and Michael A. Carducci. Human Gene Therapy for Urological Oncology, Fernando Ferrer, Jonathan W. Simons, and Ronald Rodriguez. Chemoprevention Trials for Prostate Cancer, Peter Greenwald and Ronald Lieberman. Index.
Review :
the editors have done a remarkable job in selecting the topics and compiling the various articles into a comprehensive and easily accessible volume. The chapters are concise and informative, covering highly innovative studies being conducted in the field of recent years the complexity of prostate cancer biology is well represented in the book, and the resourceful information can benefit not only those who are interested in prostate biology, but also those researchers employing molecular and cellular approaches to solve other important biological questions. - Quarterly Review of Biology a welcome addition to the literature The main strength of this book is that experts from several disciplines have contributed their thoughts on recent advances in prostate cancer I strongly recommend this book to researchers who study prostate cancer, whether at the bench or at the bedside, and to clinicians who treat patients with prostate the book covers our current knowledge of prostate cancer and its treatment and helps define the foundation for future directions. - New England Journal of Medicine Well researched and extensively referenced, the book provides a valuable source of information on the current state of understanding of the molecular biology of prostate cancer, and the treatment modalities in routine clinical practice. - ACP News Each chapter is presented in a way that provides all available knowledge on the subject and the book structure allows readers to use a single section or chapter according to their interests. All these characteristics make the book a valuable tool to general oncologists or urologists interested in updating their basic knowledge of prostate cancer. Annals of Oncology
