About the Book
The world's leading experts detail the basic rationale, scientific evidence, and treatment protocol for thrombolytic therapy in acute stroke patients. These experienced clinicians show how promptly delivered thrombolysis can restore cerebral blood flow in time to salvage brain and neurologic functions, first by reviewing the preclinical development of thrombolytics, and then by presenting the pivotal clinical trials that proved their efficacy and safety. Their description of the treatment protocol discusses field triage and management, emergency department therapy, brain imaging, clinical decision making and patient selection, drug administration, post-thrombolysis management, and the treatment of complications. Comprehensive and highly practical, Thrombolytic Therapy for Stroke offers the practicing physician everything necessary - background, protocols, and case studies - for the safe and effective treatment of the emergency stroke patient today.
Table of Contents:
Part I. Background and Basic Investigations. Mechanisms of Thrombolysis, Gregory J. del Zoppo and Naohisa Hosomi. Pathogenesis of Cervico-cranial Artery Occlusion, Louis R. Caplan. The Ischemic Penumbra and Neuronal Salvage, Patrick D. Lyden. Part II. Scientific Rationale and Clinical Trials. Pre-Clinical Testing of Thrombolytic Therapy for Stroke, Anne M. Guyot and Steven R. Levine. Combination of Thrombolytic Therapy with Neuroprotectants, James C. Grotta. Early Studies of Thrombolytic Therapy for Stroke, Anne M. Guyot, Luchi Quinones, and Steven R. Levine. Phase 2 Experience with Intravenous Thrombolytic Therapy for Acute Ischemic Stroke, E. Clarke Haley, Jr. Intravenous Thrombolytic Therapy for Acute Ischemic Stroke: Results of Large, Randomized Clinical Trials, Rashmi U. Kothari and Joseph P. Broderick. Further Analysis of NINDS Study: Long-Term Outcome, Subgroups, and Cost Effectiveness, Susan C. Fagan, Thomas Kwiatkowski, and Patrick D. Lyden. Intra-Arterial Thrombolysis in Acute Ischemic Stroke, Anthony J. Furlan, Randall Higashida, Irene Katzan, and Alex Abou-Chebl. Combinations of Intravenous and Intra-Arterial Thrombolysis, Joseph P. Broderick and Rashmi Kothari. Part III. Using Thrombolysis for Acute Stroke. The Case for Thrombolytic Therapy in Stroke Patients, Patrick D. Lyden. The Case Against the Present Guidelines for Stroke Thrombolysis: The Present Recommendations for Clinical Use Should Be Modified, Louis R. Caplan. How to Run a Code Stroke, Christopher Lewandowski. Interpretation of CT Scans for Acute Stroke, Rudiger von Kummer. Identifying and Overcoming Obstacles to Acute Stroke Treatment with rt-PA: Establishing Hospital and EMS Protocols, Karen S. Rapp and Patti Bratina. The NINDS t-PA for Acute Stroke Protocol, John R. Marler and Patrick D. Lyden. Research Directions and the Future of Stroke Therapy, Patrick D. Lyden. Part IV. Illustrative Cases. Illustrative Cases. Index.
Review :
the authors succeeded very well in their intention to make a reference work that is based not only on scientific evidence but also on their own experience in the field. - Acta Neurologica Belgica This is very much a hands on book, with much practical advice, ranging from detailed advice about the assessment and selection of patients for thrombolysis to how to set up and deliver an emergency service for stroke. The book ranges from a detailed description of the evidence from clinical trials to advice based on personal experience proceeds to an excellent account of the early trials of thrombolysis an excellent chapter follows on the techniques and interpretation of CT in acute stroke the book is highly recommended as a guide to current practice for those contemplating introducing thrombolysis into their clinical practice. - Journal of Neurology, Neurosurgery, and Psychiatry The purpose is to bring all individuals who actively manage stroke up-to-date with the current literature. The author adequately accomplishes this by doing a comprehensive review of the available research published in this field. The objectives are quite worthy and well met...The author has taken care of stroke patients for years and thus is a credible authority on the subject. The book covers all aspects of the clinical trials, outcomes, and current arguments in the field of thrombolysis. There is an excellent chapter that offers opinions from several stroke experts. Finally, the case presentations at the end of the book are well done and helpful. This is a nice wrap-up of the material. This is an excellent overview of current literature on thrombolysis for stroke. I would highly recommend it for anyone who manages the acute stroke patient. It is probably one of the best I have seen on the topic. - Doody's Health Sciences Book Review Journal The authors of this fine reference book cover all aspects of thrombolytic therapy related to cerebral ischaemia. From the pathophysiology to analysis of scientific studies to clinical use, the information in these 18 chapters may be useful to any of the physicians who threat patients in the first few hours after stroke: neurologists, neurosurgeons, emergency medicine physicians, internists, and radiologists. The authors provide data necessary for understanding the indications and limitations of thrombolytic therapy, so that even the practitioners unfamiliar with the subject can obtain sufficient information for evaluation of potential patients. All chapters are well referenced with up-to-date citations. In summary, the editor, Patrick D. Layden, has orchestrated the assembly of a superb book that provides a comprehensive source of information on thrombolytic therapy for acute stroke patients. - European Journal of Emergency Medicine Co-authored by many leaders in the field of acute stroke therapy, this book represents a thorough yet concise primer on stroke thrombolysis The strength of this book lies in its balance: it provides the reader with enough of a knowledge base to develop a good understanding of the issues surrounding stroke thrombolysis, whereas avoiding information overload. The writing is generally clear, concise, and well referenced The chapters are accompanied with informative tables and well reproduced imaging studies. The case presentations at the end provide an excellent opportunity for the reader to take what has been learned and apply it to real patient scenarios This book is intended for the wide range of clinicians involved in the care of acute stroke patients, including neurology residents, neurologists, neurosurgeons, emergency physicians, primary care providers, and emergency service coordinators. - Neurology, Official Journal of the American Academy of Neurology The strength of this book lies in its balance: it provides the reader with enough of a knowledge base to develop a good understanding of the issues surrounding stroke thrombolysis... - AAN Journal
