Myocardial Viability

Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, one that holds significant clinical and prognostic relevance. Authored by physicians of international renown, the book brings together various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of: basic concepts and mechanisms; vascular biology and cellular physiology; advances in functional imaging; and perfusion, metabolism and cell membrane integrity. New concepts, such as stunning and hibernation, are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New and sophisticated examination techniques are also presented, as well as advances in instrumentation and imaging techniques, which may result in improved use of resources and enhanced efficiency of health care delivery. This monograph will serve as a reference source for those interested in the field of myocardial viability, and hopefully improve understanding between investigators from various disciplines. Clinical cardiologists, physicians, and nurses in the field, as well as radiologists, vascular surgeons, reperfusionists, cellular biologists and physiologists, and students will all find material of interest in this book.

Table of Contents:
PrefaceV. Dilsizian Part I. Introduction 1. Perspectives on the Study of Human Myocardium: Viability V. Dilsizian Part II. Basic Concepts and Mechanisms 2. Modulation of Responses to Myocardial Ischemia: Metabolic Features of Myocardial Stunning, Hibernation, and Ischemic Preconditioning H. Taegtmeyer 3. Reversible Myocardial Dysfunction: Stunning, Hibernation, or What? F.J. Klocke, A.J. Sherman, A. Jain 4. Preconditioning J.M. Downey, M.V. Cohen Part III. Vascular Biology and Cellular Physiology 5. Experimental Models Useful in Evaluating Myocardial Viability J.T. Willerson, H.V. Anderson 6. Essential Fuels for the Heart and Mechanical RestitutionH. Taegtmeyer, R.R. Russell 7. Nitric Oxide and Energetics of the Heart: Physiology and Pathophysiology J.S. Ingwall 8. Channels, Ischemia, and Stunning: Cellular Electrophysiology and Intercellular Communication M. Ovadia, P.R. Brink Part IV. Advances in Functional Imaging 9. New Methods for Measurement of Regional and Global Ventricular FunctionS.L. Bacharach 10. Myocardial Contractile Reserve V.H. Rigolin, R.O. Bonow 11. Morphological and Echocardiographic Features of Viable and Nonviable Myocardium J. Shirani, M. Chandra, E.H. Sonnenblick 12. Timing and Myocardial Salvage: Lessons Learned From the Thromboembolytic and Revascularization Multicentre Trials T.J. Ryan Part V. Perfusion, Metabolism, and Cell Membrane Integrity 13. Introduction to Tracer Kinetics S.L. Bacharach 14. Thallium-201 Scintigraphy: Experience of Two Decades V. Dilsizian 15. Technetium-99m-Labeled Myocardial Perfusion Tracers: Blood Flow or Viability Agents? V. Dilsizian 16. Myocardial Imaging of Lipid Metabolism with Labeled Fatty Acids L.E. Feinendegen 17. Positron Emission Tomography for the Assessment of Myocardial Viability: Noninvasive Approach to Cardiac Pathophysiology H. Schoder, H.R. Schelbert 18. Nuclear Magnetic Resonance and Myocardial Viability W.J. Thoma, M.A. Lawson, W.T. Evanochko, G.M. Pohost

Review :
"Unquestionably, the book provides an excellent foundation...The editor has very skillfully organized the contributions of 27 experts in various fields of cardiology into a logical and comprehensive overview of the field of myocardial viability. Additionally, the book is enjoyable to read...The editor and all the contributors should feel very proud of this publication." --Circulation "With this monograph the editor brings much information on myocardial viability together into one place. The basic and clinical aspects of stunned and hibernating myocardium are important to clinical decision making about revascularization. These are important clinical topics and all the answers are not available. This text is a good start for interested professionals." -Doody's Review Service "Professor Dilsizian has assembled an impressive cast of renowned basic and clinical researchers to produce this comprehensive, fluent, and useful reference source."Overall, the volume is highly successful in its stated purpose of bridging basic science and clinical practice, while at the same time encompassing this broad and ever-changing field." --Texas Heart Institute Journal "This monograph represents an important update on the investigative areas relating to myocardial viability. The authors are all outstanding and among the most qualified experts in the different topics. 'This book deserves to be on the shelf of all who are interested in myocardial function. It will be of particular value to investigators in basic science, nuclear medicine physicians, radiologists, cardiologists and heart surgeons, especially those involved in clinical decision-making regarding coronary revascularization." --European Journal of Nuclear Medicine "Myocardial Viability: A Clinical and Scientific Treatise is a well-constructed series of concise chapters that address aspects important to both patient care and research...This book appears particularly well-suited for physicians with research or clinical interests in myocardial dysfunction and viability. It would be especially useful as a foundation for clinicians struggling to conduct critical reviews of original investigations in the literature, [while] basic researchers are likely to appreciate the extensive references to clinical medicine. "[This book] is likely to be a useful addition to the personal library, especially for physicians with research or clinical interests in myocardial dysfunction and viability." --Journal of Nuclear Cardiology ..".this book meets its goal of explaining the physiology of myocardial viability and how it can be assessed with both routine and advanced medical imaging methods. It should be a valuable reference for the intended audience." --Radiology ..".there are excellent, comprehensive summaries of all radionuclide approaches. In addition, there are 2 chapters that provide an excellent, balanced treatment of the echocardiographic literature. ..".illustration quality is excellent in almost all cases. "This volume is an important, useful collection of up-to-date data and provides insight into new directions in the field. It will be a very useful addition to the library of nuclear medicine physicians, cardiologists, and cardiothoracic surgeons as well as of cardiac and cellular physiology." --Journal of Nuclear Medicine "Among the many strengths of this work are that the chapters are comprehensive and clearly written; the illustrations are appropriate and helpful; most chapters represent the author's point of view, not just a summary, of specific subjects; basic science, diagnostic techniques, and clinical aspects are combined in one monographic work; the reassuring feature that chapters are written by well-known authorities in their respective areas; the concise and simple style provides accessibility for the nonspecialized reader; an extensive review of the literature is presented. "This book will interest scientists and clinicians alike. A wide spectrum of physicians, including cardiologists, nuclear medicine specialists, and those interested in cardiac metabolism, as well as scientists with an interest in myocardial viability and cardiac imaging, will find this work a useful tool for their practice as well as an inspiration for further research. Both cardiologists and nuclear medicine physicians in training, as well as medical students eager to explore problems related to myocardial viability in greater depth will find this book extremely useful." --Clinical Cardiology ""Unquestionably, the book provides an excellent foundation...The editor has very skillfully organized the contributions of 27 experts in various fields of cardiology into a logical and comprehensive overview of the field of myocardial viability. Additionally, the book is enjoyable to read...The editor and all the contributors should feel very proud of this publication."" --Circulation ""With this monograph the editor brings much information on myocardial viability together into one place. The basic and clinical aspects of stunned and hibernating myocardium are important to clinical decision making about revascularization. These are important clinical topics and all the answers are not available. This text is a good start for interested professionals."" -Doody's Review Service " "Professor Dilsizian has assembled an impressive cast of renowned basic and clinical researchers to produce this comprehensive, fluent, and useful reference source."Overall, the volume is highly successful in its stated purpose of bridging basic science and clinical practice, while at the same time encompassing this broad and ever-changing field."" "-"-Texas Heart Institute Journal ""This monograph represents an important update on the investigative areas relating to myocardial viability. The authors are all outstanding and among the most qualified experts in the different topics." "'This book deserves to be on the shelf of all who are interested in myocardial function. It will be of particular value to investigators in basic science, nuclear medicine physicians, radiologists, cardiologists and heart surgeons, especially those involved in clinical decision-making regarding coronary revascularization."" --European Journal of Nuclear Medicine ""Myocardial Viability: A Clinical and Scientific Treatise" "is a well-constructed series of concise chapters that address aspects important to both patient care and research...This book appears particularly well-suited for physicians with research or clinical interests in myocardial dysfunction and viability. It would be especially useful as a foundation for clinicians struggling to conduct critical reviews of original investigations in the literature, [while] basic researchers are likely to appreciate the extensive references to clinical medicine." ""[This book] is likely to be a useful addition to the personal library, especially for physicians with research or clinical interests in myocardial dysfunction and viability."" --Journal of Nuclear Cardiology .".".this book meets its goal of explaining the physiology of myocardial viability and how it can be assessed with both routine and advanced medical imaging methods. It should be a valuable reference for the intended audience."" --Radiology .".".there are excellent, comprehensive summaries of all radionuclide approaches. In addition, there are 2 chapters that provide an excellent, balanced treatment of the echocardiographic literature." .".".illustration quality is excellent in almost all cases." ""This volume is an important, useful collection of up-to-date data and provides insight into new directions in the field. It will be a very useful addition to the library of nuclear medicine physicians, cardiologists, and cardiothoracic surgeons as well as of cardiac and cellular physiology."" --Journal of Nuclear Medicine ""Among the many strengths of this work are that the chapters are comprehensive and clearly written; the illustrations are appropriate and helpful; most chapters represent the author's point of view, not just a summary, of specific subjects; basic science, diagnostic techniques, and clinical aspects are combined in one monographic work; the reassuring feature that chapters are written by well-known authorities in their respective areas; the concise and simple style provides accessibility for the nonspecialized reader; an extensive review of the literature is presented." ""This book will interest scientists and clinicians alike. A wide spectrum of physicians, including cardiologists, nuclear medicine specialists, and those interested in cardiac metabolism, as well as scientists with an interest in myocardial viability and cardiac imaging, will find this work a useful tool for their practice as well as an inspiration for further research. Both cardiologists and nuclear medicine physicians in training, as well as medical students eager to explore problems related to myocardial viability in greater depth will find this book extremely useful."" --Clinical Cardiology