Psoralens
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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Dermatology > Psoralens: Photochemoprotection and Other Biological Activities
Psoralens: Photochemoprotection and Other Biological Activities

Psoralens: Photochemoprotection and Other Biological Activities


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About the Book

The fifth international symposium entitled "Psoralens in 1988: Past, Present and Future" was held in Paris, April 15th-16th 1988, and this publication of the proceedings represents a fruitful cross-fertilization of ideas for newer and better uses of psoralens and UV radiation. The most rewarding and successful use of psoralen photochemotherapy has now been extended to the treatment and control of nearly 20 miscellaneous dermatoses refractory to other therapeutic approaches, including mycosis fungoides, atopic eczema, polymorphous light eruption and generalized lichen planus. The use of retinoids given concurrently with PUVA has increased the efficacy of psoralens in the treatment of psoriasis and other diseases. The concept of enhanced tanning as a defence mechanism against UV damage has received in the past much adverse publicity in the media mainly due to the concerns among several dermatologists and photobiologists that psoralens and UV radiation are carcinogenic to mice and should not be promoted for increasing tolerance to the solar radiation of normal fair-skinned individuals. After 40 years of use in thousands of patients with psoriasis and vitiligo, the carcinogenic risk of PUVA is now regarded as low and only affecting a select few individuals with certain "predisposing factors." The symposium presented experimental data both in animals and human subjects, indicating that PUVA-induced tans were associated with a melanin-rich, thickened horny layer and provided significantly greater protection against damaging UV radiation than UVB- and UVA-induced tans. This tanning process, if carried out with well regulated exposures, offers a promising future to fair-skinned white individuals in prophyulaxis of chronic sun-induced cutaneous changes (dermatoheliosis) and skin cancer. Besides reviewing the progress in the biology of melanin pigmentation (eumelanogenesis and pheomelanogenesis), the symposium provided a forum for understanding the phototoxic, pharmacologic, melanogenic and DNA-photobinding properties of new psoralen analogs, including benzopsoralens, pyrrolocoumarins, 8-azapsoralen, pyridopsoralens and furanochromones. The conference also witnessed a new, interesting area involving the actions of melanocyte-stimulating hormone (alpha-MSH) and certain synthetic alpha-melanotropin analogs in the stimulation of melanin pigmentation (pheomelanin to eumelanin shift) of mammalian skin. These results, especially in conjunction with UVA radiation and the action of PUVA, have important implications for understanding the process of melanogenesis in general and for the treatment of hypopigmentary disorders in humans (eg vitiligo). One of the most important parts of the symposium was the observation involving the stimulation of the nocturnal secretion of melatonin with oral psoralens. This suggested a new possible use of psoralens as an anti-depressant drug in controlling the circadian system of mentally depressed patients or modulating the syndrome of jet lag.

Table of Contents:
Part 1 Progress in melanogenesis: mechanisms in melanin pigmentation - an up-to-date view; photoprotective role of melanin (eumelanin) in human skin; mechanisms controlling melanin pigmentation of the skin. Part 2 Pigmentogenic effects of psoralens: psoralen induced pigmentation in human skin - overview of clinical evidence, mechanisms of induction and future research; effectiveness and safety of bergapten in sunlight-induced cutaneous pigmentation; a dose photo response study of a sunscreen product with bergapten; melanogenic potential of various furocoumarins in normal and vitiliginous skin; PUVA 5-MOP and PUVA 5-MOP + phenylalanine in the treatment of vitiligo; study of 125 patients - preliminary results. Part 3 Pharmacology and cutaneous biology of psoralens: in vivo percutaneous absorption of 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) in man and rhesus monkey; 8-MOP photosensitization in human skin - split irradiation studies; action spectrum of 8-methoxypsoralen in human skin investigated with dye-lasers in the UVA; phototoxicity after topical and pharmacokinetics after oral administration of psoralen; photosensitizing furocoumarins - photocycloaddition to unsaturated fatty acids; pyrrolocoumarin derivatives - new potential photochemotherapeutic drugs; dosage of serum 8-methoxypsoralen after oral intake in psoriatic patients treated with puvatherapy - study of 27 cases; 5-methoxypsoralen pharmacokinetics in psoriatic patients; biological activity of two tetracyclic psoralen derivatives; azapsoralens and benzoazapsoralens as new potential photochemotherapeutic agents; effect of 5-methoxypsoralen on cholesterol in cells; epidermal photosensitization by psoralens - protective effect of vitamins A and E on polyamine and free radical metabolism; influence of different vehicles and bergapten concentrations on phototumorigenic effects of UV light in HRO hairless mice; resources naturelles en furocoumarines (psoralenes); phototoxicity of bergamot oil and the lens - evaluation of the cataract incidence in workers involved in essential oil production; new psoralens and analogs; are activated oxygen species involved in PUVA-induced biological effects in vivo? Part 4 Advances in therapeutic uses of psoralens: bioavailability of 5-methoxypsoralen (5-MOP) from formulations containing the micronized and unmicronized drug; topical puvatherapy of alopecia areata with 5-methoxypsoralen creams; photochemotherapy (PUVA) of psoriasis - a double-blind comparative study of 5- and 8-methoxypsoralen; a new equipment of puvatherapy; PUVA and RE-PUVA in the treatment of mycosis fungoides - 58 cases of mycosis fungoides with 7 to 10 years follow-up; melatonin and depression - a possible role of psoralen. (part contents)


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Product Details
  • ISBN-13: 9780861960392
  • Publisher: John Libbey & Co
  • Publisher Imprint: John Libbey & Co Ltd
  • Height: 250 mm
  • Weight: 1030 gr
  • ISBN-10: 0861960394
  • Publisher Date: 01 Jan 1989
  • Binding: Hardback
  • Sub Title: Photochemoprotection and Other Biological Activities
  • Width: 230 mm


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