The Basis of Toxicity Testing
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The Basis of Toxicity Testing: (Handbooks in Pharmacology and Toxicology)

The Basis of Toxicity Testing: (Handbooks in Pharmacology and Toxicology)

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About the Book

This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies. Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.

Table of Contents:
INTRODUCTION PRELIMINARY CONSIDERATIONS Introduction The Agent Being Tested The Vehicle Routes of Administration Species Pharmacokinetics/Toxicokinetics Biotransformation Diet Endpoints of Toxicity Animal Numbers ACUTE TOXICITY STUDIES Purpose and Objectives Study Design Interpretation of Data Utility of the LD50 Studies Dermal Toxicity Studies Ocular Toxicity Studies Utility of Alternative Studies Conclusions SUBCHRONIC AND CHRONIC STUDIES Introduction Experimental Design Evaluation of Results Carcinogenicity Studies REPRODUCTIVE TOXICOLOGY Introduction Male Reproductive Toxicity Female Reproductive Toxicity Preimplantation Studies Teratogenicity Embryo Culture Harmonization Screening Tests MUTAGENESIS - CARCINOGENESIS Introduction Mutagenesis Mutagenicity Testing with Prokaryotic Cell Systems Mutagenicity Testing with Eukaryotic Cell Systems In Vitro Mutagenicity Testing with Eukaryotic Cells In Vivo The Impossibility - A Test for All Mutagens! Carcinogenicity Testing Strategies for Limited Bioassays Long-Term Carcinogenicity Studies RISK ASSESSMENT Introduction Hazard Identification Dose-Response Assessment Exposure Assessment Risk Characterization Carcinogen Classification INDEX


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Product Details
  • ISBN-13: 9780849385544
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: CRC Press Inc
  • Edition: New edition
  • Language: English
  • No of Pages: 240
  • Series Title: Handbooks in Pharmacology and Toxicology
  • Width: 178 mm
  • ISBN-10: 0849385547
  • Publisher Date: 11 Aug 1997
  • Binding: Hardback
  • Height: 254 mm
  • No of Pages: 240
  • Returnable: N
  • Weight: 662 gr


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The Basis of Toxicity Testing: (Handbooks in Pharmacology and Toxicology)
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