Molecular Basis of Oxidative Damage by Leukocytes

Molecular Basis of Oxidative Damage by Leukocytes presents papers and many discussions from the First Montana State University/Keystone Symposium at Big Sky, Montana, January 28-February 2, 1991. The purpose of this meeting was to synthesize a molecular understanding of the creation, action, and interplay of the toxic oxygen species generated by leukocytes. The book covers a variety of aspects, including the molecular basis of superoxide generation by phagocytes, the major pathways of oxidative injury, events at the leukocyte superoxide generator/target interface, regulatory events that feed back to modulate leukocyte superoxide production, and the role of leukocyte oxidants in disease. Audience will find a wealth of information in this one-of-a-kind book.

Table of Contents:
Preface and Acknowledgements. Meeting Summary (A.J. Jesaitis, M. Quinn, G. Mukherjee, P.A. Ward, and E.A. Dratz). FEATURED PRESENTATIONS. Molecular Mechanism of Activation of Leukocyte Superoxide Production (L. McPhail). Molecular Dissection of the Leukocyte Superoxide Generating System (R.A. Clark). The Flavoprotein Component of the Superoxide Generating NADPH Oxidase (A.R. Cross). The Structure of the Human Neutrophil Plasma Membrane B-Type Cytochrome Involved in Superoxide Production (C.A. Parkos, M.T. Quinn, S. Sheets, and A.J. Jesaitis). Structural Control of Electron Transfer in Proteins (D.N. Beratan). Molecular Associations of Human Neutrophil Cytochrome B (M.T. Quinn). Role of CD11/CD18 Integrins and cAMP in TNF-Induced Respiratory Burst of Human Neutrophil (M. Fuortes and C. Nathan). Organization of the Leukocyte Plasma Membrane Components of Superoxide Production (A.J. Jesaitis). Perturbation of Arachidonic Metabolism and Membrane Function by Oxidants (H. J. Forman, T.W. Robison, D.C. Skelton, and D.P. Duncan). Influence of Myeloperoxidase on Oxidant Production and Lipid Oxidation by Neutrophils (C.C. Winterbourn and A.J. Kettle). The Chemistry and Biology of Superoxide (02-): Central Concepts and Residual Problems (I. Fridovich). The Mechanism of Inactivation of Glyceraldehyde 3-Phosphate Dehydrogenase by Hydrogen Peroxide In Vitro: A Study on a Molecular Aspect of Oxidant Mediated Tissue Injury (P.A. Hyslop, W.A. Halsey Jr., D.B. Hinshaw, I.U. Shraufstatter, R.D. Sauerheber and C.G. Cochrane). Leukocyte Oxygen Products and Tissue Damage (P.A. Ward, and M.S. Mulligan). Mechanisms of Cell Damage by Oxidants (C.G. Cochrane). The Role of Neutrophils in Reperfusion Injury (B.J. Zimmerman, F.E. Landreneau, and D.N. Granger). Ischemia-Reperfusion of the Myocardium: Mechanisms of Oxidative Injury and Defense (L.S. Terada, J.M. Brown, and J.E. Repine). Electron Paramagnetic Resonance Measurements of Free Radical Generation in Isolated Cells and Whole Tissues (J.L. Zweier, P. Kuppusamy, S.M.L. Shandelya, S. Thompson-Gorman, H.F. Weisman, D.T. Fearon, and M.L. Weisfeldt). Clinical Application of Free Radical Ablation for the Prevention of Reperfusion Injury (H.J. Schiller and G.B. Bulkley). Superoxide Production by Human Phagocytes: Insights from Chronic Granulomatous Disease (J.T. Curnutte). Superoxide Production and Human Disease (J.M. McCord). POSTER PRESENTATIONS. Changes in Plasma Membrane Microheterogeneity of Polymophonuclear Leukocytes During the Activation of the Respiratory Burst (A. Kantar, P.L. Giorgi, G. Curatola, and R. Fiorini). The Respiratory Burst Oxidase and its Relationship with the Cytoskeleton of Human Neutrophils (R.C. Woodman, J.M. Ruedi, A.J. Jesaitis, N. Okamura, M.T. Quinn, R.M. Smith, J.T. Curnutte, and B.M. Babior). Superoxide Production by Murine Tumour-Associated Macrophages in Inhibited by a Species Acting on the Signal Transduction Pathway (S.J. Eason and B.M. Hannigan). Correlations and Dissociations Between Superoxide Production and Adhesion Function of Human Neutrophils (P. Bellavite, S. Chirumbolo, G. Poli, and C. Mansoldo). Nitric Oxide Medulates Leukocyte Adhesion to Vascular Endothelium (P. Kubes, J. Russell, M. Suzuki, and D.N. Granger). Biological Surfaces Differentially Affect 02- Production by Human Neutrophils (NEU) and Eosinophils (EOS) (P. Dri, R. Cramer, P. Spessotto, M. Romano, and P. Patriarca). Differential Regulation of Reactive Nitrogen and Reactive Oxygen Intermediate Production by Hepatic Macrophages and Endothelial Cells (C.R. Gardner, D.E. Heck, L.S. Feder, T.W. McCloskey, J.D. Laskin, and D.L. Laskin). Activation of Carcinogens by the Systems Simulating Oxidants Generated by Polymorphonuclear Leukocytes (D. Malejka-Giganti, C.L. Ritter , and R.W. Decker). Electron Microscopic Immunocytochemical Localization of Lipid Peroxidation Products in Phagocytosing Human Neutrophils (J.G. Linner, E.S. Buescher, D. Siemsen, E.A. Dratz, M.T. Quinn, and A.J. Jesaitis). Generation of Reactive Oxygen Intermediates by Leukocytes Treated with Psoralens and Ultraviolet Light (D.E. Heck, E. Bisaccia, S. Armus, and J.D. Laskin). Secretion of Enzymatically Active Human Recombinant Myeloperoxidase by Chinese Hamster Ovary Cells in Culture (N. Moguilevsky, L. Garcia-Quintana, A. Jacquet, C. Tournay, L. Fabry, L. Pierard, and A. Bollen). Myeloperoxidase-Dependent Formation of Benzo(a)pyrene-7,8-DIOL DNA Adducts by Stimulated Pulmonary Neutrophils (J.M. Petruska, D.R. Mosebrook, G.J. Jakab, and M.A. Trush). Modulation of Endothelial Cell Injury All-Trans Retinoic Acid (RA): Role in the Anti-Inflammatory Effects of RA (J. Varani and K.J. Johnson). Transgenic Expression of Glutathione Peroxidases in Human Breast Cells: Increased Resistance to Clastogenic Oxidants (M.-E. Mirault, A. Tremblay, L. Lavoie, M. Tremblay, and N. Beaudoin). Comparison of Oxidative Damage and Inhibition of FE Uptake in HL60 Cells from a Mono or BIS Thiosemicarbazone Copper Complex (W.E. Antholine, J. Narasimhan, C.R. Chitambar, and D.H. Petering). Expression of Superoxide Dismutase During Endothelial Cell Stress (N.V. Ketis and J. Jones). Manganese Superoxide Dismutase Appears to be Associated with the Neutrophil Plasma Membrane (M.L. McCormick, L.W. Oberley, T.D. Oberley, and B.E. Britigan). Increased Neutrophil Radical Production, Increased Lipid Peroxidation and Increased Consumption of Antioxidants in HIV-Infected Patients (C. Jarstrand, O. Rasool, B. Akerlund, and B. Lindeke). Constitutive Extracellular Release of Phosphatidylcholine Preferring Phospholipase C (PC-PLC) by Human Fibroblasts and Smooth Muscle Cells (L.I. Gordon, D. Gutstein, S. Prachand and S.A. Weitzman). Cardiovasculatr Effects of Activated Polymorphonuclear Leukocytes (K. Prasad, J. Kalra, and D. Debnath). Oxidative Damage of Normal and Neoplastic Epidermal Cells by Stimulated Polymorphonuclear Leukocytes in Man (R.E. Schopf, C. Ziegler, M. Rehder, and B. Morsches). The Role of Oxidants in Influenza-Induced Airway Hyperactivity in Rats (J.S. Tepper, J.R. Lehmann, G. Dupont, J.R. Hoidal, D.L. Costa, G.R. Burleson, and T.P. Kennedy). The Role of Neutrophils in Hepatic Ischemia-Reperfusion Injury (H. Jaeschke, C.W. Smith, H. Hughes, and A. Farhood).