Hypercoagulable StatesFundamental Aspects, Acquired Disorders, and Congenital Thrombophilia

Hypercoagulable States presents cutting edge scientific knowledge of hypercoagulability, a condition characterized by increased predisposition to blood clotting. The text provides a common language to enhance understanding between clinicians and clinical pathologists in the laboratory.

Table of Contents:
Introduction Hypercoagulable States: An Overview, J. Seghatchian and M.M. Samama FUNDAMENTAL ASPECTS AND LABORATORY APPROACHES Fundamental Aspects of Haemostasis/Thrombosis Tissue Factor, Flow, and the Initiation of Coagulation, Y. Nemerson and P.B. Contino Platelet Procoagulant Activity and Microvesicle Formation, R.F.A. Zwaal, P. Confurius, E. Smeets, and E.M. Bevers Monocytes and Hypercoagulable States, B. Østerud The Protein C Anticoagulant Pathway and Heparin-Antithrombin Mechanism, K.A. Bauer and R.D. Rosenberg Study of the Prothrombotic State using Perfusion Systems, Y. Cadroy Diagnostic Strategies and Laboratory Approaches Laboratory Diagnosis of Hereditary Thrombophilia, F.E. Preston and M. Greaves Diagnosis of Activation States of Circulating Platelets, M.C. Trzeciak, J.C. Bordet, and M. Dechavanne Von Willebrand Factor in Thrombotic Disorders, M.J. Seghatchian, A.A. Halle, T. McKiernan, S. Johnson, S. Farid, and H.L. Messmore, Jr. Critical Evaluation of Fibrinogen Assays, M.P.M. de Maat and F. Haverkate Fibrinolysis and the Hypercoagulable State, P.J. Gaffney Biological Markers of Acute Venous Thrombosis and Pulmonary Embolism, H. Bounameaux Assessment of Fibrinolysis in Patients with Thrombosis-From Laboratory to Clinical Practice, J. Gram and J. Jespersen Decreased Fibrinolytic Activity in Thrombotic Disease: An Update, B. Wiman and A. Hamsten Drug and Blood Products Induced Hypercoagulability Drug-Induced Hypercoagulability, M. Greaves and F.E. Preston Drug-Dependent Platelet Activating IgG: Heparin and Streptokinase, T. Lecompte Warfarin-Induced Hypercoagulability: Standardisation of Laboratory Aspects and Management of Skin Necrosis, M.J. Seghatchian and M.M. Samama Paradoxical Hypercoagulability Induced by Thrombolytic Drugs, G. Helft and M.M. Samama Update on Thrombogenicity of FIX and FXI Concentrates: Laboratory and Clinical Aspects of the Induced Hypercoagulability, J. Goudemand and M.J. Seghatchian Artificial Surfaces and Hypercoagulability, M.J. Seghatchian ACQUIRED DISORDERS AND CONGENITAL THROMBOPHILIA Acquired Disorders: Epidemiology, Pathophysiological Conditions Haemostatic Variables and Arterial Thrombotic Disease: Epidemiological Evidence, P.Y. Scarabin Hyperlipidaemia and Blood Coagulation, M.P. Esnouf Antiphospholipid Antibody Syndrome, D.A. Triplett Peptide Markers in Hypercoagulability Associated with Coronary Heart Disease, G.J. Miller Hypercoagulability and Cancer, H.C. Kwaan Hypercoagulable States and Pregnancy, J. Bonnar Hypercoagulability in Children and Neonates, N. Schlegel Hypercoagulability and Diabetes Mellitus, S.C.L. Gough and C.R.M. Prentice Hematological Disorders and Stroke, M.J. Seghatchian, T. Baglin, and M.M. Samama Paroxysmal Nocturnal Hemoglobinuria: Pathogenesis and Clinical Manifestations of Thrombosis, T. Plesner, H. Birgens, and N.E. Hansen Spinal Cord Injury: Pathophysiology, Hypercoagulability, and Clinical Management, D. Green and D. Chen Hypercoagulability in Surgical Patients, G.D.O. Lowe Hypercoagulability, Inflammatory Cytokines, Disseminated Intravascular Coagulation, and Hyperfibrinolysis, M.J. Seghatchian and M.M. Samama Congenital Thrombophilia: Clinical Aspects, Diagnosis, and Management Antithrombin, Its Deficiency, and Venous Thromboembolism, D.A. Lane, R.J. Olds, and S.L. Thein Antithrombin III Deficiency: Laboratory Aspects and Clinical Management, M.J. Seghatchian, M.M. Samama, and J. Conard Hereditary Protein C and Protein S Deficiency, I. Elalamy, J. Conard, M.H. Horellou, P. Van Dreden, and M.M. Samama Inherited Resistance to Activated Protein C: A Single Point Mutation in the Gene for Factor V as a Major Risk Factor for Venous Thrombosis, B. Dahlback Heparin Cofactor II, P. Sié Hereditary Dysfibrinogenemia, Afibrinogenemia, Hypofibrinogenemia, and Thrombosis, M.M. Samama, and F. Haverkate Plasma Fibrin Gel Architecture and Thrombotic Disorder, J.P. Collet, J. Soria, M. Mirshahi, Z. Mishal, M. Vasse, J.P. Caen, and C. Soria Plasminogen Alteration, T. Koyama and N. Aoki Hyperhomocysteinemia and Vascular Disease, G. Palareti, C. Legnani, and S. Coccheri Sickle Cell Disease, E. Verdy and R. Girot A Life-Long Hypercoagulable State in ß-Thalassemia Major Patients, A. Eldor, J. Maclouf, A. Goldfarb, R. Durst, M.C. Guillin, and E.A. Rachmilewitz Arterial Thrombosis with Thrombocytopenia, H. Messmore, W.H. Wehrmacher, and M.J. Seghatchian Therapeutic Aspects The Long Search Toward Ideal Antithrombin Drugs, M. Verstraete