CRC Handbook of Laboratory Safety, 4th Edition

This Fourth Edition of the CRC Handbook of Laboratory Safety expands and updates the discussions found in the previous editions. The latest technologies and issues are incorporated to keep managers and laboratory personnel up-to-date on effective programs to meet the needs of new regulations. Since the publication of the previous edition, the anticipated realization of numerous standards has become fact. The present edition contains material on all of these. Every attempt has been made to ensure that the current edition is as up-to-date as possible by continually reviewing current regulatory standards. Every article has been revised to reflect the newest changes. Topics may be similar but the content may have changed significantly. The wealth of information easily accessible in this new edition continues to make the CRC Handbook of Laboratory Safety an essential reference tool. The Fourth Edition covers the numerous actions that have significant impact on laboratory safety, including: New OSHA laboratory safety standards 1994 NRC radiation safety standards Guidelines for X-ray use in hospitals Enforcement of the standard for dealing with blood-borne pathogens, including the Ryan White Act Changes in DOT regulations on the packaging of hazardous materials EPA action on the release of radioactive materials into the environment OSHA actions covering hazardous waste operations and emergency response New CDC guidelines for research with microbiological hazards

Table of Contents:
Introduction Laboratory Safety as a Cooperative Responsibility Organizational Structure The Safety Department Departmental Responsibilities Laboratory Responsibilities References Emergencies Components of Emergency Preparedness Initial Conditions. Facilities, Fixed and Movable Equipment Institutional or Corporate Emergency Committee Emergency Plan Laboratory Emergency Plan. Organizational Emergency Plan. Emergency Equipment. Basic Emergency Procedures. Emergency Procedures for Selected Emergencies. Artificial Respiration, Cardiopulmonary Resuscitation (CPR), and First Aid Laboratory Facilities-Design and Equipment Laboratory Design Engineering and Architectural Principles. Building Codes and Regulatory Requirements. Laboratory Classification. Access. Construction and Interior Finish. Ventilation. Electrical Systems. Plumbing. Other Laboratory Utilities. Maintenance Factors. Fixed Equipment and Furniture Laboratory Furniture. Hoods. Built-In Safety Equipment. Other Fixed Equipment Chemical Storage Rooms Capacity. Construction Features. Ventilation. Fire Safety. Movable Equipment Refrigeration Equipment. Ovens. Heating Baths. Stills. Kjeldahl Systems. Autoclaves. Animal Laboratories Special Requirements Fixed Equipment in Animal Holding Facilities. Equipment for Animal Laboratories and Holding Areas. Appendix: Vertebrate Animal Safety Boisafety Level Criteria. Laboratory Operations General Considerations OSHA Laboratory Safety Standard The Chemical Laboratory. Chemical Hygiene Plan Operational Planning Quantities. Sources. Material Safety Data Sheets. Purchase of Regulated Items. Free Materials Purchasing of Animals Storage Compatible Chemical Storage. Labeling. Regulated Materials. Ethers. Perchloric Acid. Flammable Liquids. Refrigeration Storage. Gas Cylinders. Animal Food and Supply Storage. Handling and Use of Chemicals in Laboratory Operations Physical Laboratory Conditions. Working Procedures. Hazard Awareness (Right-to-Know) Basic Requirements. Written Hazard Communication Program. Health Effects Exposure Limits. Environmental Monitoring. Modes of Exposure. Health Assurance Program. The OSHA Blood-borne Pathogen Standard: Infection from Work with Human Specimens. Pregnancy in the Laboratory. Regulated and Potential Carcinogens. Neurological Hazards of Solvents. Spills and Emergencies Small-to Moderate-Scale Spills. Large-Scale Releases of Chemicals. Chemical Wastes Resource Conservation and Recovery Act. Practical Hazardous Waste Management Program. State-of-the-Art Hospital and Institutional Waste Incineration, Selection, Procurement, and Operations Laboratory Closeout Procedures Nonchemical Laboratories Introduction Radioisotope Laboratories Natural Radioactivity. Basic Concepts. Licensing. Radiation Protection, Discussion, and Definitions. Radioisotope Facilities and Practices. Material Control Procedures. Operations. Radon. Acute Radiation Syndrome. X-Ray Facilities Generation of X-Rays. Types of Machines Non-Ionizing Radiation Guidelines on Limits of Exposure to Radiofrequency Electromagnetic Fields in the Frequency Range From 100 kHz to 300 GHz Laser Laboratories Protective Procedures for Class IIIb and Class IV Lasers. Eye Protection. Medical Surveillance. Microbiological and Biomedical Laboratories Introduction. Laboratory Safety and Hazard Communication Standards. Laboratory Director. Miscellaneous Safety Practices. Accidents and Spills of Biohazardous Materials. Generation of Aerosols. Infectious Waste. Laboratory Facilities-Design and Equipment. Biosafety Levels. Recommended Biosafety Levels. Recombinant DNA Laboratories Definition of Recombinant DNA Molecules. General Applicability. Containment. Guidelines in Covered Experiments. Roles and Responsibilities. Appendices. Research Animal Care and Handling Introduction. Laws and Regulations Relating to Animal Care and Use. Personnel. Animal Holding Facilities. Animal Care and Handling. Human Health Monitoring. Personal Protective Equipment Introduction Respiratory Protection Eye Protection Materials for Protective Apparel Hearing Protection First Aid Kits References Appendix: Laboratory Checklist Index