Ion Mobility Spectrometry, Second Edition

Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase ion chemistry and mobility. Beginning with a thorough discussion of the fundamental theories and physics of ion mobility, Ion Mobility Spectrometry, Second Edition describes the recent advances in instrumentation and newly pioneered applications. Divided into three sections, the first presents a history of technological developments, basic principles, theories, and other factors that govern the response in IMS. The second section describes aspects of IMS technology including sample introduction methods, draft tubes, modern methods for data analysis and display, the combination of mobility spectrometers with chromatographic methods, miniaturized IMS sensors, alternative ionization sources, and advances in computational capabilities that improved the acquisition and treatment of data. The final section emphasizes rapidly developing and exciting applications of IMS. The section is subdivided into existing, proven and potential applications encompassing the traditional forensic, military, and counter-terrorism applications and the now well-developed methods for detect biological agents and characterizing bio-molecules. It also highlights other applications found in clinical and environmental venues and await further development. This new edition of Ion Mobility Spectrometry offers a lucid and complete analysis of the technological and contextual developments surrounding the chemistry, instrumentation and growing number of applications of IMS that incorporate and depend upon the latest innovations in the field.

Table of Contents:
PART I: HISTORY, THEORY, AND BASIC PRINCIPLES OF ION MOBILITY SPECTROMETRY Introduction to Ion Mobility Spectrometry Background Studies of Ions in Gases at Atmospheric Pressure Early Developments of IMS as an Analytical Method (1970 to 1990) Modern Analytical IMS Present and Future Trends in IMS References Mobility of Ions in the Gas Phase Introduction Motion of Slow Ions in Gases Models for Ion–Neutral Interactions Models and Experimental Evidence Dependence of Mobility on Electric Field References Appendix A: Sensitivity of Calculated Mobilities toward the Choice of Parameters Gas-Phase Ion Chemistry in Mobility Spectrometers Introduction and General Considerations Ion Chemistry at Ambient Pressure Analytical Facets of Gas-Phase Ion Reactions The Interpretation of Mobility Spectra Summary References PART II: TECHNOLOGY OF ION MOBILITY SPECTROMETRY Drift Tubes for Mobility Spectrometers Introduction Inlets and Introduction of Sample Ion Sources Drift Tubes Selection of Materials Summary References Hyphenated Methods with Mobility Spectrometers Introduction to Hyphenated Ion Mobility Spectrometry (IMS) Methods GC/IMS LC/IMS IMS/MS Summary References PART III: APPLICATIONS OF ION MOBILITY SPECTROMETRY Forensics, Military, Security, and Counterterrorism Introduction Chemical Weapons Detection of Explosives by IMS Drugs Other Forensic Applications Conclusions References Biologial, Biomolecular Research, and Medical Uses of IMS Introduction Medical Diagnostics Using IMS Food Freshness and Odor Detection Proteins, Peptides, Amino Acids, and Other Large Biomolecules and Biopolymers Detection and Determination of Bacteria Conclusion References Developed Applications in Industrial and Environmental Monitoring Introduction Acidic and Corrosive Gases Volatile Organic Compounds and Halocarbons Ammonia in Water, Air, Clean Rooms, and Process Streams Gas Purity and Trap Efficiency SF Purity in Electrical Switches Semiconductor Manufacturing Recirculated or Controlled Atmospheres VOCs in the Air of the International Space Station Conclusion References Feasible Applications Introduction Occupational Hygiene and Air Quality Fugitive Emissions from Industrial Activity Smoke Alarm with Identification of Combustion Sources Surface Analysis and Adsorbed Layers Metal and Inorganic Ions Aerosols and Electric Mobility Analyzers Summary References Present Conditions, Barriers to Advances, and Future Developments in Ion Mobility Spectrometry State of the Science and Technology of Ion Mobility Spectrometry (IMS) Barriers to Advances in Performance and Uses Future for IMS Final Thoughts

Review :
"...The second edition of this book provides a timely update to the fundamental theory, advancements in instrumentation, and the development of new applications of IMS... The book accomplishes the objectives outlined by the authors... The CD [is] a useful and practical addition to this book... Overall, this book should be useful to experts in IMS research as well as those new to the technology. As a practical book, it offers a well-balanced combination of theory and application... I highly recommend it to anyone interested in IMS. " -- Robert G. Ewing, New Mexico Institute of Mining and Technology, in JACS, Vol. 128, 2006