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Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pharmacology > Peptide-based Drug Design: Controlling Transport and Metabolism(ACS Professional Reference Books)
Peptide-based Drug Design: Controlling Transport and Metabolism(ACS Professional Reference Books)

Peptide-based Drug Design: Controlling Transport and Metabolism(ACS Professional Reference Books)


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About the Book

This volume presents a contemporary understanding of protein and peptide transport mechanisms and metabolism as a framework for facilitating the design, and evaluation of peptidomimetic and other peptide-based drugs that combine high intrinsic potency with improved drug delivery properties. The book provides an introductory chapter addressing the molecular biology of amino acid and peptide transport. It includes sections on: intestinal peptide transport; blood-brain barrier peptide transport; peptide transport in microorganisms; and peptide metabolism.

Table of Contents:
Introduction: molecular biology of amino acid, peptide and oligopeptide transport, Rufus M. Williamson and Dale L. Oxender; peptide metabolism at brush-border membranes, Roger H. Erickson; peptide metabolism by gastric, pancreatic and lysosomal proteinases, Ramesh Krishnamoorthy and Ashim K. Mitra; biopharmaceutical properties and pharmacokinetics of peptide drugs, Hye J. Lee; intestinal peptide transport. Part 1 Intestinal absorption of B-lactam antibiotics, Akira Tsuji; oral absorption of angiotensin-converting enzyme inhibitors and peptide prodrugs, Shiyin Yee and Gordon L. Amidon; the intestinal oligopeptide transporter - molecular characterization and substrate specificity, Werner Kramer et al; oral delivery of therapeutic proteins and peptides by the B12-uptake system, Gregory J. Russell-Jones; prodrug approaches for improving peptidomimetic drug absorption, Barbra H. Stewart and Michael D. Taylor. Part 2 Liver peptide transport: hepatic processing of peptides, David L. Marks; approaches to modulating liver transport of peptide drugs, Mary L. Ruwart. Part 3 Blood-brain barrier peptide transport: blood-brain barrier peptide transport and peptide drug delivery to the brain, William M. Pardridge; oligopeptide drug delivery to the brain - importance of absorptive-mediated endocytosis and P-glycoprotein-associated active efflux transport at the blood-brain barrier, Tetsuya Terasaki and Akira Tsuji; molecular packaging - peptide delivery to the central nervous system by sequential metabolism, Nicholas Bodor and Laszlo Prokai. Part 4 Peptide transport in micro-organisms: bacterial peptide permeases as a drug delivery target, J. W. Payne; fungal peptide transport as a drug delivery system, Jeffrey M. Becker and Fred R. Naider. Part 5 Peptide metabolism: peptidomimetic design and chemistry approaches to peptide metabolism, T.K. Sawyer; peptide prodrugs designed to limit metabolism, Judi Moss; improving duration of action of peptide drugs, John J. Nestor Jr. Part 6 Methods and systems for evaluating transport and metabolism of peptide-based drugs - cell culture models for examining peptide absorption, Donald W. Miller et al; Elsbeth G. Chikale and Ronald T. Borchardt; gastrointestinal transport of peptides - experimental systems, David Fleisher; in vitro models of hepatic uptake - methods to determine kinetic parameters for receptor-mediated hepatic uptake, Yuichi Sugiyama and Yukio Kato.


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Product Details
  • ISBN-13: 9780841230583
  • Publisher: American Chemical Society
  • Publisher Imprint: American Chemical Society
  • Height: 254 mm
  • Returnable: N
  • Sub Title: Controlling Transport and Metabolism
  • ISBN-10: 0841230587
  • Publisher Date: 05 May 1995
  • Binding: Hardback
  • Language: English
  • Series Title: ACS Professional Reference Books
  • Width: 178 mm


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Peptide-based Drug Design: Controlling Transport and Metabolism(ACS Professional Reference Books)
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