Inhaled Glucocorticoids in Asthma: Mechanisms and Clinical Actions(97 Lung Biology in Health and Disease)

Offers in-depth, interdisciplinary discussions on the pharmacology of corticosteroids in relation to their use in the treatment of airway diseases-focusing on specific issues that apply to topically active glucocorticoids.

Table of Contents:
Subcellular Actions of Glucocorticoids Glucocorticoid Receptor Structure and Function, Roger L. Miesfeld and John W. Bloom Negative Transcriptional Regulation by the Glucocorticoid Receptor Is Responsible for the Anti-Inflammatory Activity of Glucocorticoids, Michael Karin and Fahri Saatcioglu Glucocorticoids Attenuate Induction of Two Primary Response Immediate Early Genes Prostaglandin Synthase 2 and Inducible Nitric Oxide Synthase, Whose Products Mediate Paracrine Cell Communication, Harvey Herschman, Rebecca Gilbert, Srinivasa Reddy, Bradley Fletcher, Weiln Xie, Jeffrey Smith, and Dean Kujubu Glucocorticoids and Apoptosis of Hematopoietic Cells: Transcriptional and Posttranscriptional Control, E. Brad Thompson Lymphocyte Activation: The Interplay and Synergy of Immunosuppressants, Isabella Graef, Neil Clipstone, Steffan N. Ho, Luika A. Timmerman, Jeffrey Northrop, and Gerald R. Crabtree Effects on Airway Mucosa and Submucosa Airway Ultrastructure in Asthma, Lauri A. Laitinen and Annika Laitinen Sputum Indices of Inflammation in Asthma, Frederick E. Hargreave, Emilio Pizzichini, Marcia Pizzichini, Ann Efthimiadis, Jerry Dolovich, and Paul M. O'Byrne Tissue Remodeling and Fibroblast Heterogeneity in Asthma and Other Chronic Airways Inflammatory Diseases, Jack Gauldie, Patricia J. Sime, Guy M. Tremblay, Diane Torry, Manel Jordana, and Bengt Sarnstrand Airway Microcirculation, Epithelium, and Glucocorticoids, Carl G. A. Persson Inhibition of Inflammatory Cell Recruitment by Glucocorticoids: Cytokines as Primary Targets, Robert P. Schleimer, Lisa A. Beck, Lisa A. Schweibert, Cristiana Stellato, Kelly Davenpeck, and Bruce S. Bochner Airway Lymphocytes, Stephen R. Durham, Chris J. Corrigan, Douglas S. Robinson, Quatayba Hamid, and A. B. Kay Effects of Corticosteroids on Basophils and Mast Cells, Judah A. Denburg Glucocorticoid Effects on Human Eosinophils, Gerald J. Gleich, Loren W. Hunt, Bruce S. Bochner, and Robert P. Schleimer Cytokines and Growth Factors in Asthma, Stephen J. Lane, David J. Cousins, Ana R. Sousa, Dontcho Z. Staynov, and Tak H. Lee Glucocorticoid Activity and Selectivity at the Airway Level Basis of Airway Selectivity of Inhaled Glucocorticoids, Ralph Brattsand and Bengt I. Axelsson Glucocorticoid Pharmacokinetics: Principles and Clinical Applications, Staffan Edsbäcker and Stanley J. Szefler Determinants of Dose and Response to Inhaled Therapeutic Agents in Asthma, Gerald C. Smaldone Clinical Aspects A Comparison of Inhaled Versus Oral Corticosteroids as Maintenance Therapy in Asthma, William W. Busse Inhaled Corticosteroids in Asthma: Importance of Early Intervention, Paul M. O'Byrne Role of Glucocorticoids in the Therapy of Acute Asthma, E. R. McFadden, Jr. Corticosteroids in the Treatment of Allergic Rhinitis, Peter H. Howarth Efficacy and Safety of Inhaled Corticosteroids in Children, Søren E. Pedersen Effects of Inhaled Steroid Therapy for Asthma of Skeletal Metabolism, John H. Toogood Steroid-Resistant Asthma, Donald Y. M. Leung Prospects Inhaled Glucocorticoids in Asthma: Current Understanding and Future Directions, Peter J. Barnes