Handbook of Multiple Sclerosis, Third Edition: (Neurological Disease and Therapy)

Reporting on the latest advances made in treating multiple sclerosis (MS) and continuing the high standards set by earlier editions, the Handbook of Multiple Sclerosis, Third Edition examines a wide range of topics from etiology to treatment options. Analyzes recent developments in the natural history, immunopathology, lesion evolution, and therapy affecting MS treatment-including up-to-date research results from experimental therapies with t-cell vaccines, oral myelin, and monoclonal antibodies! Summarizing previous breakthroughs and pointing the way toward future research, the Handbook of Multiple Sclerosis, Third Edition provides a historical summary of the disease and examines the epidemiology and genetics of MS, including new evidence for and against an infectious etiology investigates virus-induced demyelination, emphasizing models such as canine distemper (CDV), corona, visna, and herpes simplex viruses; the semliki forest virus (SFV); and animal models of autoimmune demyelination notes the role of magnetic resonance imaging (MRI) in diagnosis, prognosis, natural history, and as a guide to therapy explores the growing evidence for axonal damage as a major cause of disability in MS summarizes the natural history of MS and delineates factors influencing exacerbations and progression of the disease assesses current clinical and biological prognostic indicators for accurate diagnoses of MS as opposed to other idiopathic inflammatory demyelinating diseases (IIDDs) and evaluates the growing number of therapies for treating MS and more!

Table of Contents:
Etiopathogenesis The History of Multiple Sclerosis W. I. McDonald The Epidemiology of Multiple Sclerosis William Pryse-Phillips and Fiona Costello The Genetics of Multiple Sclerosis Jan Hillert and Thomas Masterman Experimental Models of Virus-Induced Demyelination Mauro C. Dal Canto Evidence for a Viral Etiology of Multiple Sclerosis Stuart D. Cook Experimental Models of Autoimmune Demyelination Fred D. Lublin Evidence for Immunopathogenesis Ute Traugott Autoantibodies in Demyelinating Disease Anne H. Cross, Jeri-Anne Lyons, and John L. Trotter Clinical Pathologic Features Clinical Features Aaron E. Miller Cognitive Impairment in Multiple Sclerosis Jill S. Fischer Loss and Restoration of Impulse Conduction in Disorders of Myelin Stephen G. Waxman Pathology of Multiple Sclerosis John W. Prineas Axonal Injury in Multiple Sclerosis Carl Bjartmar and Bruce D. Trapp Cerebrospinal Fluid John N. Whitaker, Khurram Bashir, and Etty N. Benveniste Laboratory Tests: Evoked Potentials Marc R. Nuwer Neuroimaging and the Use of Magnetic Resonance in Multiple Sclerosis Lael A. Stone, Nancy Richert, and Henry McFarland Therapeutic Considerations The Natural History of Multiple Sclerosis Sandra Vukusic and Christian Confavreux Prognostic Factors in Multiple Sclerosis Orhun H. Kantarci and Brian G. Weinshenker Therapeutic Considerations: Rating Scales Richard Rudick, Brian Weinshenker, and Gary Cutter Therapeutic Considerations: Treatment of the Acute Exacerbation Raymond Troiano Interferon- -1b: Prophylactic Therapy in Multiple Sclerosis Kenneth P. Johnson and Peter A. Calabresi Therapeutic Considerations: Prophylactic Therapy with Interferon- -1a Lawrence Jacobs Prophylactic Therapy-Glatiramer Acetate (Copaxone®) Hillel Panitch Treatment of Multiple Sclerosis with Intravenous Immunoglobulin P. Rudge Immunosuppressive Drugs Mariko Kita and Donald E. Goodkin Treatment of Multiple Sclerosis: Bone Marrow Reconstitution, Total Lymphoid Irradiation, and Plasma Exchange George P. A. Rice Symptomatic Therapy Randall T. Schapiro Symptomatic Treatment and Rehabilitation in Multiple Sclerosis Charles R. Smith and Labe Scheinberg Experimental Therapies with T-Cell Vaccines, Oral Myelin, and Monoclonal Antibodies in Multiple Sclerosis Suprabha Bhat and Jerry S. Wolinsky Future Immunotherapies Christine Rohowsky-Kochan

Review :
"International praise for the previous editions... This is a substantial multi-authored text covering all the important aspects of current knowledge on multiple sclerosis.... ...well produced, illustrated and abounds with well-chosen references... "-Journal of Neurology, Neurosurgery and Psychiatry ...a well-written book that describes both classic and recent knowledge about multiple sclerosis. The contributors are outstanding.... ...clearly and comprehensively organized. -Canadian Medical Association Journal ...a Baedeker of multiple sclerosis research, and a guide to the basic neurobiology of the disorder.... ...excellent sections of undeniable general appeal and great practical use. -Annals of Internal Medicine ...most useful to residents and fellows in neurology...to neurologic clinicians, who are interested in comprehensive and current advances...and to both basic and clinical investigators. -Mayo Clinic Proceedings ...helps to understand the links between the actual knowledge...and the therapies that are applicable in patients....This book is useful for neurologists who have a special interest in multiple sclerosis and look for an overview as well as for the rationale for using newly developed therapies. -European Neurology "present[s] the latest information concerning the immunopathology of this disease and new treatment modalities for those cursed with this affliction. highly recommended for all academic health science library collections. "-E-Streams