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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Diseases and disorders > Immunology > A Survey of Models for Tumor-Immune System Dynamics: (Modeling and Simulation in Science, Engineering and Technology)
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A Survey of Models for Tumor-Immune System Dynamics: (Modeling and Simulation in Science, Engineering and Technology)

A Survey of Models for Tumor-Immune System Dynamics: (Modeling and Simulation in Science, Engineering and Technology)


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About the Book

A collection of seven interdisciplinary surveys on modelling tumour dynamics and interactions between tumours and immune systems. Modelling and simulation of general behaviours of immune systems is also discussed. Each survey covers a specialized field and provides a detailed description of the current state of research. the reader should be able to obtain essential information on the methodological approach used and on the models that are categorized and used. Topics covered include: general tumour biology modelling; growth kinetics; kinetic cellular theory; tumour-immune system interactions; and heterogeneity and growth control. There is also a glossary of scientific terms in immunology and biology to ensure a clear understanding of biological terms.

Table of Contents:
1. A Brief History of Immunologic Thinking: Is it Time for Yin and Yang?.- 1.1 Koch’s Postulates.- 1.2 Aristotle’s Laws of Logical Argument.- 1.3 Antigens and T-Cell Responses.- 1.4 Thinking About the Immune System.- 1.5 Fuzzy T-Cell Model.- 1.6 Acknowledgment.- 2. General Aspects of Modeling Tumor Growth and Immune Response.- 2.1 Introduction.- 2.2 What is a Mathematical Model?.- 2.3 Introduction to Deterministic Tumor (or Spheroid) Growth Models.- 2.4 A Predator-Prey Approach.- 2.5 A Model of Tumor Cell/Immune System Interaction.- 2.6 Models, Metaphors and Similes: Some Alternative Paradigms.- 2.7 References.- 2.8 Appendices.- 3. Mathematical Modeling of Tumor Growth Kinetics.- 3.1 Introduction.- 3.2 Tumor Growth as a Dynamical System.- 3.3 The Gompertz Model.- 3.4 The Logistic Model.- 3.5 Models of von Bertalanffy.- 3.6 Tumor Growth Modeled by Specific Mechanisms.- 3.7 Mathematical Models and Measured Growth Curves.- 3.8 Concluding Outlooks.- 3.9 Acknowledgment.- 3.10 References.- 4. Tumor Immune System Interactions: The Kinetic Cellular Theory.- 4.1 Introduction.- 4.2 A Concise Guide to the Literature.- 4.3 Guidelines: From Observation to Simulation.- 4.4 Cell Population and Activity.- 4.5 Modeling Cell Interactions.- 4.6 Evolution Kinetic Equations.- 4.7 Experimental Activity.- 4.8 Simulation and Validation Problems.- 4.9 Remarks Addressed to Applied Mathematicians.- 4.10 Perspectives.- 4.11 References.- 5. From Mutation to Metastasis: The Mathematical Modelling of the Stages of Tumour Development.- 5.1 Introduction.- 5.2 Avascular Tumour Growth: The Multicell Spheroid Model.- 5.3 Thmour Angiogenesis. Capillary Sprout Formation and Growth.- 5.4 Vascular Tumour Growth.- 5.5 Discussion and Conclusions.- 5.6 References.- 6. Basic Models of Tumor-Immune SystemInteractions Identification, Analysis and Predictions.- 6.1 Introduction.- 6.2 Kinetics Models of Cellular Cytotoxic Reactions at the Effector Stage of Immune Response.- 6.3 Regulatory Cells at the Effector Stage of the Cellular Immune Response.- 6.4 Modeling of the Recognition Mechanisms of Thmor Cells by NK-like Cells.- 6.5 Switch of Cytolytic Mechanisms: Effector Cells, Target Cells and Bispecific Regulating Molecules.- 6.6 Propagation and Interaction of Tumor Specific Macromolecules in Multicellular Tumors.- 6.7 Conclusion.- 6.8 Acknowledgment.- 6.9 References.- 7. Tumor Heterogeneity and Growth Control.- 7.1 Introduction.- 7.2 The Goal.- 7.3 The Plan.- 7.4 The Foundation and Tools.- 7.5 The Structure.- 7.6 Conclusions.- 7.7 References.- 8. Biological Glossary.

Review :
"This book is [a] very helpful tool for mathematicians constructing models in biology and hopefully it can also help biologists to understand some philosophy of mathematical descriptions of biological phenomena with all its pluses and minuses." —Mathematica Bohemica


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Product Details
  • ISBN-13: 9780817639013
  • Publisher: Birkhauser Boston Inc
  • Publisher Imprint: Birkhauser Boston Inc
  • Height: 235 mm
  • No of Pages: 344
  • Returnable: Y
  • Width: 155 mm
  • ISBN-10: 0817639012
  • Publisher Date: 01 Dec 1996
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Series Title: Modeling and Simulation in Science, Engineering and Technology


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