About the Book
Designed for Learning. Grounded in Science. Built for Practice.
This comprehensive, first-edition text, developed specifically for advanced practice education, explores the cellular and molecular mechanisms of disease, organ-specific pathologies, and multisystem disorders with an emphasis on evidence-based application.
Students learn pathophysiology while simultaneously connecting it to related key concepts in pharmacology and assessment, enabling them to grasp not only what is happening in the body, but also how it intersects with the "3P" cornerstones of clinical decision-making. This approach reinforces the interconnected nature of advanced practice knowledge and better prepares students to deliver optimal real-world patient care.
- "Assessment Connection" and "Pharmacology Connection" boxes link pathophysiology, pharmacology, and assessment concepts, helping students to tie together the 3Ps and understand how their integration supports precise, informed clinical decisions.
- “Learning Outcomes” are consistent with the relevant domains and outcomes advocated by the National Organization of Nurse Practitioner Faculty (NONPF) and Collegiate Commission on Nursing Education (CCNE) for competency-based graduate education.
- Clinical exemplars address how, where, and most importantly, why foundational concepts apply to clinical practice.
- "Clinical Connection" boxes inform how a pathophysiologic concept or process relates to clinical practice, including diagnostic reasoning and selection of management strategies.
- "Patho Point" and "Physio Point" boxes highlight important high-yield facts/ /
- "Pediatric Point" and "Gero Point" boxes identify key clinical considerations for populations across the lifespan.
- "Social Determinants of Health" boxes identify economic or other disparities that might impact access to or delivery of care.
- "Genetic/Genomic Point" boxes articulate how a specific genetic alteration or identified pattern of inheritance influences a diagnosis.
- "Zebra" lists detail unusual or rare conditions diagnosed and managed by specialists, but that the primary care practitioner should be aware of as a collaborator in clinical care.
- "So, Why?/So You Know" boxes explain complicated concepts using easy-to-grasp analogies or clinical application examples.
Table of Contents:
PART I: FOUNDATIONAL PHYSIOLOGIC CONCEPTS
I.The Cell
1.Cellular Biology, Regulation, and Control Mechanisms
2.Cellular and Tissue Physiology
3.Bioenergetics and Body Metabolism
4.Body Fluid Homeostasis
II.Genetics and Genomics
5.Basic Genetics
6.Patterns of Inheritance, Mitochondrial Inheritance, Epigeneticand Selected Associated Disorders
III.Inflammation, Immunity, Infection, and Cancer Biology
7.Innate Immunity and Inflammation
8.Adaptive Immunity
9.Infectious Processes and Body Responses
10.Abnormal Cell Growth and Cancer Biology
PART II: PATHOPHYSIOLOGY OF DISORDERS WITHIN SPECIFIC BODY SYSTEMS
OXYGENATION AND PERFUSION
IV.Cardiovascular System
11.Review of Cardiovascular Development, Structure, and Function
12.Vascular Disorders
13.Cardiac Disorders
14.Congenital Heart Disease Across the Lifespan
15.Shock and Multiple Organ Dysfunction Syndrome
V.Pulmonary System
16.Review of Pulmonary Structure, Development, and Function
17.Congenital, Obstructive, and Restrictive Pulmonary Disorders
18.Infectious Pulmonary Disorders and Lung Cancer
VI.Renal-Urinary System
19.Review of Renal System Structure, Development, and Function
20.Urinary Tract Disorders
21.Kidney Disorders
VII.Hematologic and Lymphatic System
22.Chapter 22.Review of Hematologic System Development, Structure, and Function
23.Chapter 23.Hematologic and Lymphatic System Disorders
SENSATION, MOBILITY, AND REGULATION
VIII.Nervous System
24.Review of Nervous System Development, Structure, and Function
25.Central Nervous System Disorders
26.Peripheral Nervous System Disorder
27.Disorders of the Special Senses
28.Mental Health Disorders
IX.Musculoskeletal System
29.Review of Musculoskeletal Development, Structure, and Function
30.Muscle and Tendon Disorders
31.Bone and Joint Disorders
X.Endocrine System
32.Review of Endocrine Structure, Function, and Interactions
33.Disorders of the Hypothalamus, Pituitary Glands, and Adrenal Glands
34.Disorders of the Thyroid Gland and the Parathyroid Glands
35.Glycemic Control and Diabetes Mellitus
PROTECTION, NUTRITION, AND REPRODUCTION
XI.Disorders of Immunity
36.Disorders of Reduced Immune Function
37.Hypersensitivity and Autoimmune Disorders
XII.Integumentary System
38.Review of Integumentary Development, Structure, and Function
39.Integumentary System Disorder
XIII.Digestive System
40.Review of Gastrointestinal Development, Structure, and Function
41.Disorders of the Mouth, Throat, Esophagus, and Stomach
42.Disorders of the Small Intestine, Large Intestine, Pancreas, and Hepatobiliary System
XIV.Reproductive Systems
43.Review of Reproductive System Development, Structure, Function, and Sex Chromosome Abnormalities
44.Common Disorders of the Female Reproductive System
45.Male Reproductive Disorders
46.Sexually Transmitted Infections
47. Physiology and Pathophysiology of the Breast
About the Author :
Adjunct Faculty, Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland Ohio Formerly Professor, School of Nursing and Health Studies, University of Miami, Coral Gables Florida
