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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Diseases and disorders > Oncology > Clinical Applications of Cytokines and Growth Factors: (80 Developments in Oncology)
Clinical Applications of Cytokines and Growth Factors: (80 Developments in Oncology)

Clinical Applications of Cytokines and Growth Factors: (80 Developments in Oncology)


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About the Book

The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off invading microbes by humoral, cell-mediated, and phagocytic immunity. Today several growth factors are available to the clinician as treatments for various pathologic perturbations of hematopoiesis. Their use has also advanced our capacity to safely deliver cancer chemotherapy. Hematopoietic growth factors have become an everyday tool for the practicing oncologist. Here, experts review the biological interactions between hematopoietic progenitors, growth factors and cytokines, and the stromal micro-environment that have provided the scientific basis for our current understanding of hematopoiesis. In subsequent sections the pathophysiology of neutropenia, anemia and thrombocytopenia are presented, along with discussions of the clinical challenges these pose for the practicing oncologist and hematologist and the roles of various hematopoietic growth factors in therapeutic strategies for these entities.

Table of Contents:
I. Biology of Hematopoietic and Lymphopoietic Cytokines.- 1. Cytokines, Growth Factors, and Hematopoiesis.- 2. The Interaction of Cytokines with Stem Cell and Stromal Cell Physiology.- 3. The Interaction of Cytokines with T-cell and Natural Killer Cell Physiology.- 4. Improving on Nature by Re-Engineering Hematopoietic Growth Factors.- II. Management of Neutropenia and Neutropenic Fever.- 5. The Influence of Colony Stimulating Factors on Neutrophil Production, Distribution, and Function.- 6. Evidence-Based Use of Hematopoietic Cytokines in Clinical Oncology.- 7. Economic, Public Health, and Policy Implications of Hematopoietic Growth Factors, High-Dose Chemotherapy, and Stem Cell Rescue.- 8. Outpatient Management of Neutropenic Fever: Antibiotics, Growth Factors or Both?.- 9. The Use of Hematopoietic Growth Factors for Recruitment of Leukocytes for Transfusion.- III. Management of Anemia.- 10. Pathophysiology of the Anemia of Malignancy.- 11. The Use of Recombinant Erythropoietin in the Treatment and Prevention of Cancer and Chemotherapy Related Anemia.- IV Management of Thrombocytopenia.- 12. Regulation of Human Megakaryocytopoiesis.- 13. The Effects of Multilineage Cytokines on Platelet Recovery.- 14. Clinical Studies of Thrombopoietin.- V. The Role of Cytokines to Enhance Cancer Chemotherapy.- 15. Dose Intensification in Solid Tumor Chemotherapy.- 16. Conventional and High Dose Chemotherapy for Lymphomas.- 17. Hematopoietic Growth Factors in Acute Leukemia.- VI. Management of Marrow Failure States.- 18. Cytokines for the Treatment of Myelodysplastic Syndromes and Other Bone Marrow Failure States.- VII The Use of Cytokines in Blood and Marrow Transplantation.- 19. Stem Cell Collection for Hematopoietic Transplantation: Stem Cell Sources, Mobilization Strategies, and Factors that Influence Yield.- 20. Mechanisms of Growth Factor Mobilization of Hematopoietic Progenitors.- 21. The Use of Cytokines to Enhance Collection of Stem Cells for Marrow and Blood Transplantation.- 22. The Use of Cytokines During Blood and Marrow Transplantation.


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Product Details
  • ISBN-13: 9780792384861
  • Publisher: Kluwer Academic Publishers
  • Publisher Imprint: Kluwer Academic Publishers
  • Height: 235 mm
  • No of Pages: 407
  • Returnable: Y
  • Width: 155 mm
  • ISBN-10: 0792384865
  • Publisher Date: 31 May 1999
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Series Title: 80 Developments in Oncology


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Clinical Applications of Cytokines and Growth Factors: (80 Developments in Oncology)
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