Buy Cardiovascular Specific Gene Expression by Robert S. Reneman
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Clinical and internal medicine > Cardiovascular medicine > Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)
Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)

Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)


     0     
5
4
3
2
1



International Edition


X
About the Book

The development of the heart and vessels during embryogenesis depends on the complex interplay of various cell types and growth factors. The implementation of molecular tools has enabled us to analyse early steps in cardiogenesis and vasculogenesis. Furthermore the introduction of transgenic and knock-out techniques in mice, and the miniaturization of physiologic measurements to the mouse level has fundamentally changed our knowledge. Pathophysiology can be unravelled at the molecular level. The implications of various stimuli on specific membrane receptors can be analyzed. In response to receptor activation, interacting intracellular signalling pathways can activate or block transcription factors. The changes in gene expression lead to functional changes observed in the cardiovascular systems of animal models and humans. Changes in the level of gene expression and protein function in cardiovascular disease are discussed for the sarcomeric, calcium handling and ion channel genes. Furthermore, different approaches to the design of cell-type-specific gene therapy approaches for the heart and vessels are outlined.

Table of Contents:
1. Cardiology approaching the year 2000. A clinician’s look at molecular cardiology.- One: Cardiovascular specific gene expression.- 2. The transcriptional building blocks of the heart.- 3. A cardiac-specific troponin I promoter. Distinctive patterns of regulation in cultured fetal cardiomyocytes, adult heart and transgenic mice.- 4. Mice deficient in muscle LIM protein (MLP) reveal a pathway to dilated cardiomyopathy and heart failure.- 5. Regulation of endothelial cell specific receptor tyrosine kinase gene expression during development and disease.- 6. Smoothelins: one gene, two proteins, three muscle cell types .... so far.- Two: Transcription regulation.- 7. Regionalization of transcriptional potential in the myocardium: ‘cardiosensor’ transgenic mice.- 8. Human troponin genes: transcriptional regulation and chromosomal organization.- 9. Retinoid signaling: insight from genetically engineered mice.- 10. Ventricular expression of the atrial regulatory myosin light chain gene.- 11. Expression of rat gap junction protein connexin 40 in the heart.- three: Ion channels and gap junction.- 12. Sympathetic regulation of cardiac delayed rectification: relationship to cardiac arrhythmias.- 13. The sarco(endo)plasmic reticulum Ca2+ pumps in the cardiovascular system.- 14. Potassium channels; genes, proteins, and patients.- 15. Expression of Cx43 in cardiac and aortic muscle cells of hypertensive rats.- 16. Genetic engineering and cardiac ion channels.- four: Intracellular signaling.- 17. Receptor tyrosine kinase signaling in vasculogenesis and angiogenesis.- 18. Molecular analysis of vascular development and disorders.- 19. Crosstalk between the estrogen receptor and the insulin-like growth factor (IGF-1) receptor. Implications for cardiac disease.- 20. Expression ofbasic helix-loop-helix proteins and smooth muscle phenotype in the adult rat aorta.- 21. Expression of the IGF system in acute and chronic ischemia.- 22. Long-chain fatty acids and signal transduction in the cardiac muscle cell.- five: DNA transfer.- 23. Reduction of kidney renin expression by ribozymes.- 24. Receptor-dependent cell specific delivery of antisense oligonucleotides.- 25. Tissue-specific gene delivery by recombinant adenoviruses containing cardiac-specific promoters.- 26. Catheter-mediated delivery of recombinant adenovirus to the vessel wall to inhibit restenosis.


Best Sellers


Product Details
  • ISBN-13: 9780792356332
  • Publisher: Kluwer Academic Publishers
  • Publisher Imprint: Kluwer Academic Publishers
  • Height: 235 mm
  • No of Pages: 330
  • Returnable: Y
  • Width: 155 mm
  • ISBN-10: 0792356330
  • Publisher Date: 30 Apr 1999
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Series Title: 214 Developments in Cardiovascular Medicine


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)
Kluwer Academic Publishers -
Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Cardiovascular Specific Gene Expression: (214 Developments in Cardiovascular Medicine)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!