Delayed Preconditioning and Adaptive Cardioprotection
Home > Medicine & Health Science textbooks > Clinical and internal medicine > Cardiovascular medicine > Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)
Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)

Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)


     0     
5
4
3
2
1



International Edition


X
About the Book

Interest in the ability of myocardium to adapt to ischaemic stress has continued to grow since the discovery of ischaemic preconditioning in 1986. In 1993, two reports heralded the recognition of a delayed preconditioning response in the heart, now commonly known as the `second window' of protection. Since then, a number of studies have described the ability of delayed preconditioning and related adaptive phenomena to protect against a variety of pathologies in the ischaemic and reperfused myocardium. Our understanding of the cellular mechanisms of sub-acute adaptive cardioprotection has advanced considerably during this period. This compilation of state-of-the-art reviews by those who have made significant contributions to this field provides detailed and critical analysis of this research, from molecular basis to potential clinical relevance. The book aims to provide an authoritative, comprehensive and thoroughly up-to-date overview for scientists and clinicians engaged in, or observing, this rapidly-developing area of heart research. It will also be of interest to those engaged in research on other tissues where ischaemia-reperfusion pathology is of major concern.

Table of Contents:
1 Delayed Preconditioning Against Lethal Ischaemic Injury.- 1. Introduction.- 2. Background.- 3. Discovery of Delayed Preconditioning.- 4. Characteristics of Delayed Preconditioning Against Infarction.- 5. Delayed Preconditioning Against Myocyte Injury In Vitro.- 6. Delayed Preconditioning Against Ischaemic Injury in Other Tissues.- 7. Mechanisms of Delayed Preconditioning.- 8. Triggers of Adaptation in Delayed Preconditioning.- 9. Signal Transduction in Delayed Preconditioning.- 10. Downstream Mediators and Possible Effectors of Protection.- 11. Conclusions.- References.- 2 Delayed Preconditioning Against Myocardial Stunning.- 1. Introduction.- 2. Pathophysiology of Late Preconditioning Against Stunning.- 3. The Preconditioning Stimulus or ‘Trigger’ of Late PC.- 4. The Signal Transduction Pathways of Late PC.- 5. The Mediator(s) of the Protective Effects of Late PC.- 6. The Nitric Oxide Hypothesis of Late PC.- 7. Conclusions.- References.- 3 Delayed Preconditioning Against Endothelial Dysfunction.- 1. Introduction.- 2. Reperfusion Injury to Endothelial Cells.- 3. Evidence for Delayed Preconditioning of Coronary Endothelial Cells.- 4. Mechanisms of Delayed Protection.- 5. Mediators of Protection.- 6. Triggers of Protection.- 7. Conclusion.- References.- 4 Delayed Preconditioning Against Ventricular Arrhythmias.- 1. Introduction.- 2. Experimental Background.- 3. From Early to Delayed Protection.- 4. Delayed Protection Against Arrhythmias by Cardiac Pacing.- 5. Time Course and Renewal of Delayed Protection.- 6. Delayed Protection Against Arrhythmias Induced by Prostacyclin.- 7. Delayed Protection Against Arrhythmias Induced by Endotoxins.- 8. Delayed Protection Against Arrhythmias Induced by Catecholamines.- 9. Roles of NO and Bradykinin in Delayed Protection AgainstArrhythmias.- 10. Conclusion.- References.- 5 Intracellular Signalling Mechanisms in Myocardial Adaptation to Ischaemia.- 1. Introduction.- 2. Stress Adaptation in the Heart.- 3. Signal Transduction Pathways in Adaptation.- 4. Protein Tyrosine Kinase Signalling.- 5. Phospholipase D Signalling.- 6. Protein Kinase C Signalling.- 7. Mitogen Activated Protein Kinases.- 8. p38 MAP Kinase Signalling.- 9. MAPKAP Kinase 2.- 10. Gene Expression.- 11. Conclusion.- References.- 6 Changes in Cardiac Gene Expression After Ischaemia and Reperfusion.- 1. Introduction.- 2. Methodological Considerations.- 3. Pathophysiological Considerations.- 4. Examination of Gene Regulation.- 5. Transcription Factors.- 6. Cytokines and Growth Factors.- 7. Sarcoplasmic Reticulum Calcium Regulating Proteins.- 8. Antioxidants.- 9. Miscellaneous.- 10. Perspective and Conclusion.- References.- 7 The Heat Shock Response and Tissue Protection.- 1. Introduction.- 2. Heat Shock and HSP70.- 3. Heat Shock, HSP70 and Inducible Cellular Protection in the Heart.- 4. HSP70 Transgenic Mice and Myocardial Protection.- 5. Function of HSP70.- 6. Inducible Cellular Protection in the Brain.- 7. Other Possibilities.- 8. HSP27 and Endogenous Cellular Protection.- 9. HSP27 in the Heart and Brain.- 10. Conclusions.- References.- 8 Antioxidant Defences in Myocardial Adaptation.- 1. Introduction.- 2. Sublethal Ischaemia-induced Cardioprotection.- 3. Sublethal Heat Stress-induced Cardioprotection.- 4. Exercise and Cardioprotection.- 5. Production of Oxygen Free Radicals and Biphasic Cardioprotection.- 6. Conclusion.- References.- 9 Endotoxin, Monophosphoryl Lipid A and Delayed Cardioprotection.- 1. Introduction.- 2. Effects of MLA and LPS on Myocardial Infarct Size.- 3. Effects of MLA and LPS on Myocardial Stunning.- 4. Role of Neutrophils in MLA- and LPS-induced Infarct Size Reduction.- 5. Role of Heat Shock Proteins in MLA- and LPS-induced Cardioprotection.- 6. Role of ATP-Sensitive Potassium Channels (KATP) in MLA-induced Infarct Size Reduction.- 7. Role of KATP Channels in MLA-induced Attenuation of Stunning.- 8. Role of Adenosine in the Cardioprotective Effect of MLA.- 9. Role of NO in MLA-induced Cardioprotection.- 10. Conclusion.- References.- 10 Adenosine and Delayed Cardioprotection.- 1. Introduction.- 2. Adenosine as a Trigger of Delayed Preconditioning.- 3. Time Course and Maintenance of Adenosine-induced Delayed Cardioprotection.- 4. Signal Transduction Mechanisms.- 5. Distal Mediator(s) of Adenosine-induced Delayed Protection.- 6. Conclusion.- References.- 11 Angina and Cardiac Adaptation.- 1. Introduction.- 2. Preinfarction Angina.- 3. From Experimental Laboratory to Humans.- 4. Pathophysiological Studies.- 5. Retrospective Clinical Studies.- 6. Prospective Clinical Trials.- 7. Preinfarction Angina: Is Preconditioning the Only Mechanism of Protection?.- 8. Conclusion.- References.

Review :
`This book is recommended for physiologists, cardiologists, and cardiac surgeons vaguely aware of the concept, who want to know more about it.' Acta cardiologica, 54:3 (1999) `... this up-to-date review of literature is timely... the editors have done a commendable job of assembling well known experts...to compile this essential review of delayed preconditioning research.' The Bulletin, 13:2 (2000)


Best Sellers


Product Details
  • ISBN-13: 9780792352594
  • Publisher: Kluwer Academic Publishers
  • Publisher Imprint: Kluwer Academic Publishers
  • Height: 244 mm
  • No of Pages: 230
  • Returnable: Y
  • Width: 170 mm
  • ISBN-10: 0792352599
  • Publisher Date: 31 Oct 1998
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Series Title: 207 Developments in Cardiovascular Medicine


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)
Kluwer Academic Publishers -
Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Delayed Preconditioning and Adaptive Cardioprotection: (207 Developments in Cardiovascular Medicine)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    New Arrivals


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!