Cholecystokinin and Its Antagonists in Pain Management
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Cholecystokinin and Its Antagonists in Pain Management

Cholecystokinin and Its Antagonists in Pain Management


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About the Book

Examine the strong evidence of this unrealized pain management tool Cholecystokinin (CCK), the regulatory peptide hormone found primarily in the gastrointestinal tract that works as a neurotransmitter throughout the nervous system, has been researched for years. CCK antagonists in conjunction with opioids are beginning to be seen as having possible major therapeutic benefits in pain management. Cholecystokinin and Its Antagonists in Pain Management is an extensive examination that gathers the mounting compelling evidence into one comprehensive source. Here researchers, neuroscientists, physicians, and pharmacy professionals are given the research and findings they need to explore the possible applications of CCK antagonists for a variety of illnesses. Cholecystokinin and Its Antagonists in Pain Management extensively describes opioids in pain management, CCK and the body’s uses for the chemical, CCK receptor antagonists, and the evidence that points to its being a possible breakthrough application in pain management. Various animal studies are offered that present a convincing view of what may be the future of chronic pain management, with less side effects and a reduction in analgesic tolerance than when opioids are used alone. Potential uses of CCK antagonists are clearly discussed. The book is comprehensively referenced and provides several tables and graphs to fully illustrate the research findings. Topics in Cholecystokinin and Its Antagonists in Pain Management include: in vivo localization of CCK CCK as a gut and nervous system peptide factors that increase CCK anti-opioid effects CCK receptor antagonists pro-analgesic effect of CCK antagonists CCK antagonists reducing analgesic tolerance to opioids safety of combining opioids and CCK antagonists human clinical application of CCK antagonists Cholecystokinin and Its Antagonists in Pain Management is a crucial source of the latest information and research results on CCK that is certain to be important for neuroscientists, clinicians, and pharmaceutical industry professionals.

Table of Contents:
Chapter 1. Introduction Chapter 2. Opioids in Pain Management Codeine Dihydrocodeine Tramadol Morphine Oxycodone Fentanyl Hydromorphone Buprenorphine Conclusions Chapter 3. Cholecystokinin The Original Description of Cholecystokinin Molecular Characteristics of Cholecystokinin Synthesis and Degradation of Cholecystokinin Chapter 4. Cholecystokinin As a Gut Peptide Cholecystokinin Release Effect of CCK Chapter 5. Cholecystokinin As a Central Nervous System Peptide CCK A and CCK B Distribution of CCK Receptors Chapter 6. Central Effect of Cholecystokinin Opioid Receptors and Intracellular Calcium Noradrenaline Release in the Rat Supraoptic Nucleus Dynorphin Delta Opioid Receptors Rostral Ventromedial Medulla Dopamine Alpha Adrenergic Receptors Chapter 7. Factors That Increase Central Cholecystokinin Representation Potassium Neural Injury Gamma-Aminobutyric Acid Vasoactive Intestinal Peptide Morphine Chapter 8. Cholecystokinin As an Antiopioid Peptide Effect of CCK on Opioid Antinociception Influence of CCK Type on Opioid Antinociception Chapter 9. Cholecystokinin Receptor Antagonists Mixed CCK A and B Antagonists CCK A Antagonists CCK B Antagonists Alternative Classification CCK Antagonists with Other Effects Chapter 10. Do Cholecystokinin Antagonists Influence Opioid-Derived Antinociception? Proglumide PD134,308/CI988 L365,260 PD135,158 Comparisons Between CCK Antagonists CCK Antagonists and Enkephalins CCK Antagonists and Tricyclic Antidepressants Summary Chapter 11. Do CCK Antagonists Reduce Tolerance to the Antinociceptive Effects of Opioids? Effect of CCK Antagonists on Antinociceptive Effect of Opioids Effect on Morphine Dependence Conclusions Chapter 12. Is the Combination of Opioids and CCK Antagonists Safe? L364,718 and Squirrel Monkeys L365,260 and Humans Conclusion Chapter 13. Human Studies of the Combination of CCK Antagonists and Opioids Experimental Pain Postsurgical Pain Cancer Pain Chronic Benign Pain Neuropathic Pain Analgesic Tolerance Diet and Its Effect on Endogenous CCK Levels Issues with the Human Literature Conclusions Chapter 14. Other Potential Uses of CCK Antagonists Biliary Colic Pancreatitis Anxiolysis Dependence and Withdrawal Reactions Conclusions Chapter 15. Conclusions Notes Index


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Product Details
  • ISBN-13: 9780789028938
  • Publisher: Taylor & Francis Inc
  • Publisher Imprint: Haworth Press Inc
  • Language: English
  • No of Pages: 145
  • Returnable: N
  • ISBN-10: 078902893X
  • Publisher Date: 01 Sep 2006
  • Binding: Paperback
  • No of Pages: 145
  • Returnable: N
  • Weight: 249 gr


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