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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Diseases and disorders > Infectious and contagious diseases > Viruses: Agents of Evolutionary Invention
Viruses: Agents of Evolutionary Invention

Viruses: Agents of Evolutionary Invention


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About the Book

While viruses—the world’s most abundant biological entities—are not technically alive, they invade, replicate, and evolve within living cells. Michael Cordingley goes beyond our familiarity with infections to show how viruses spur evolutionary change in their hosts and shape global ecosystems, from ocean photosynthesis to drug-resistant bacteria.

Table of Contents:
Cover Title Page Copyright Contents Introduction 1. Obligate Parasites of Cells The Virosphere and Its Metagenome Complexity and “Dark Matter” Selfish Information and the Essence of Being Viral The Emergence of Egotistical Replicators The Viral Empire 2. Viruses, Genes, and Ecosystems Lifestyles and Life Cycles Lysogeny: Exercising Temperance Kill the Winner Gene Brokers Selfishness Drives Adaptive Evolution Phages and the Microbiome Unfriendly Competition Chemical Warfare 3. Potentiation of Bacterial Diseases by Phages For a Charm of Powerful Trouble Toxic Enablers Choose Your Poison Treasure Islands Prophage Induction and Antibiotic Drug Resistance Viruses, Cells, Organisms, and Populations “Just a Virus” Human Rhinoviruses Uncommon Diversity Accidents of Pathogenesis Mutation, Diversity, and Quasipecies 5. The Flu: No Common Cold Antigenic Escape Artists Human Influenza A Virus Epidemic Influenza: Dress for the Season Quasispecies, Sequence Clusters, and Codon Bias Correlating Genetic and Antigenic Evolution Seeding of Seasonal Epidemics Pandemic Influenza: The Emperor with No Clothes 6. Alternative Virus Lifestyles Latency: Till Death Do Us Part All in the Family Herpesviridae 7. Evolutionary Mechanisms of DNA Viruses Gene Duplication and Gene Capture Poxvirus Evolution Poxvirus Party Tricks Small DNA Virus Evolution 8. Viroids and Megaviruses: Extremes Viroids: The Smallest Evolutionary Reliquary Megaviruses: The Biggest Big and Bigger Virophages: Fleas upon Fleas Chimerism Megavirus Origins: Mavericks at Heart 9. HIV-1: A Very Modern Pandemic A New Disease and a New Virus Anatomy of HIV-1 HIV in the Making Socioepidemiology of AIDS: A Man-Made Epidemic Within-Host Evolution: A Very Personal Arms Race Shortsighted Evolution Adaptive Evolution: An Evolving Relationship Outrunning the Red Queen Medicine at the Virus-Host Interface Resistance Is Futile 10. Cross-Species Infections: Means and Opportunity A Rogue’s Gallery of Emerging Viruses Adaptive Evolution in Zoonosis Fitness Landscape A Shifting Fitness Landscape The Paradox in RNA Virus Evolution RNA Viruses and Molecular Clocks Arboviruses: Vector-Borne Viruses Evolutionary Compromise Host Restriction 11. Future Pandemic Influenza: Enemy at the Gates Real and Present Danger Pandemic Threat Level The Pandemic Phenotype Outbreak 12. Ebolavirus EBOV Makona What We Were Afraid to Say about Ebola Evolution or Adaptive Change EBOV Persistence 13. Viral Zoonoses and Animal Reservoirs The Usual Suspects Filovirus Origins Bats and Viral Zoonoses A Special Relationship Tolerance and Resistance 14. Endogenous Retroviruses: Our Viral Heritage Genome Invasion by Retroviruses Endogenization in Progress Change Agents Domestication of ERV Genes Endogenous Viral Elements 15. Viruses as Human Tools Myxoma Virus: Biological Control Genomics of an Attenuated Poxvirus Orthopoxviruses: Past Solutions and Future Problems Live-Attenuated Viruses Attenuation by Design Virus Therapeutics Doctor’s Little Helpers Oncolytic Viruses 16. Conclusion: Humanity and Viruses The Human Future and Viruses Beauty in Design References Acknowledgments Index

Review :
Michael Cordingley has written an engaging and enlightening description of viruses from a refreshingly different viewpoint, as agents that drive not only their own evolution, but that of their hosts.
-- Vincent Racaniello, Columbia University
This is a much needed book on a subject that has long been overlooked. The author has done an excellent job of communicating how viruses are core agents in the evolution of life. Anyone interested in the evolution of life should read this book.
-- Luis P. Villarreal, University of California, Irvine
Michael Cordingley describes the complex life of viruses from the perspective of evolutionary agents. With carefully selected and easily understandable examples, he makes the argument that viruses follow the laws of Darwinian evolution. This book is highly recommended for microbiologists and individuals who care about global health care.
-- Peter Sarnow, Stanford University School of Medicine
Provides an amazing connection between the multiple scales or dimensions that viruses play at, together with the evolutionary processes and mechanisms...This a fascinating book intended for readers interested in the evolution of microbes, but also for specialists working in the field. The volume provides key systems and examples that allow better comprehension of the complexity of viruses.
-- Josep Sardanyés Quarterly Review of Biology


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Product Details
  • ISBN-13: 9780674978638
  • Publisher: Harvard University Press
  • Publisher Imprint: Harvard University Press
  • Edition: Digital original
  • No of Pages: 384
  • ISBN-10: 0674978633
  • Publisher Date: 19 Jun 2017
  • Binding: Digital (delivered electronically)
  • Language: English
  • Sub Title: Agents of Evolutionary Invention


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