Testosterone: Action, Deficiency, Substitution

This book provides the most comprehensive and up-to-date source of information on testosterone and other androgens, and their role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behaviour, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and lipids, erection, and the prostate. Therapeutic uses of testosterone preparations are carefully evaluated, including use in women, the aging male, and its abuse and detection in sport. The book reviews applications in male contraception, the role of 5a-reductase inhibitors and the controversial use of DHEA. For this book the editors have assembled the world leaders in testosterone research and clinical andrology and endocrinology. A special feature of the book is the fact that its 24 chapters were submitted simultaneously to insure rapid publication. This revised and significantly expanded edition will serve as the standard source of reference for many years.

Table of Contents:
Preface; 1. Testosterone: an overview of biosynthesis, transport, metabolism and non-genomic actions F. F. G. Rommerts; 2. The androgen receptor: molecular biology H. Klocker, J. Gromoll and A. C. B. Cato; 3. Androgen receptor: pathophysiology O. Hiort and M. Zitzmann; 4. Behavioural correlates of testosterone K. Christiansen; 5. The role of testosterone in spermatogenesis G. F. Weinbauer, M. Niehaus and E. Nieschlag; 6. Androgens and hair: a biological paradox V. A. Randall; 7. Androgens and bone metabolism M. Zitzmann and E. Nieschlag; 8. Testosterone effects on the skeletal muscle S. Bhasin, T. W. Storer, A. B. Singh, L. Woodhouse, R. Singh, J. Artaza, W. E. Taylor, I. Sinha-Hikim, R. Jasuja and N. Gonzalez-Cadavid; 9. Androgens and erythropoiesis M. Zitzmann and E. Nieschlag; 10. Testosterone and cardiovascular diseases A. von Eckardstein and F. C. W. Wu; 11. Testosterone and erection H. M. Behre; 12. Testosterone and the prostate J. T. Isaacs; 13. Clinical use of testosterone in hypogonadism and other conditions E. Nieschlag and H. M. Behre; 14. Pharmacology of testosterone preparations H. M. Behre, C. Wang, D. J. Handelsman and E. Nieschlag; 15. Androgen therapy in non-gonadal disease P. Y. Liu and D. J. Handelsman; 16. Androgens in male senescence J. M. Kaufman, G. T'Sjoen and A. Vermeulen; 17. The pathobiology of androgens in women N. Burger and P. Casson; 18. Clinical use of 5a-reductase inhibitors K. D. Kaufman; 19. Dehydroepiandrosterone (DHEA) and androstenedione B. Allolio and W. Arlt; 20. Selective androgen receptor modulators (SARMs) S. S. Wolf and M. Obendorf; 21. Methodology for measuring testosterone, DHT and SHBG in a clinical setting M. Simoni; 22. Synthesis and pharmacological profiling of new orally active steroidal androgens A. Grootenhuis, M. de Gooyer, J. van der Louw, R. Bursi and D. Leysen; 23. Hormonal male contraception: the essential role of testosterone E. Nieschlag, A. Kamischke and H. M. Behre; 24. Abuse of androgens and detection of illegal use W. Schänzer; Index.

Review :
'... I was deeply impressed by the brilliance of selection and organization of topics, their authors, technical format and clear and instructive literary styles, which all result from the excellent editorial work ... The book certainly should be considered an important contribution to understand the contemporary knowledge about testosterone and about androgens in general.' Endocrine Regulations 'This book should be read not only by scientists dealing with steroid hormones but also by every doctor treating patients with androgen deficiency. It presents the current knowledge concerning androgen replacement therapy in a convincing manner.' Blackwell Verlag 'There is much to commend in this book ... an impressive overview.' The Endocrinologist 'This book should be read not only by scientists dealing with steroid hormones but also by every doctor treating patients with androgen deficiency. It presents the current knowledge concerning androgen replacement therapy in a convincing manner.' Andrologia '... provides a update encyclopedia on testosterone for the years to come. the book is well edited and illustrated and concluded by a detailed index. The volume belongs in the library of all those who deal with men, both clinically and scientifically.' The Aging Male 'This is the third edition of what has become a standard reference work on all things androgenic ... there is much to commend in this book ... it remains an impressive overview of the area and the major changes made since the 1998 version are to the good.' Human Fertility 'This book is a must reference for any practitioner or researcher who is going to be involved with measuring or prescribing testosterone or, for that matter, any androgen. It is so comprehensive that urologists who consider themselves a subspecialist in either oncology, impotence, infertility or geriatrics will find the information in this tome pertinent to their subspecialty.' The Journal of Urology