Antidotes for Poisoning by Cyanide
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Antidotes for Poisoning by Cyanide: (Series Number 2 International Programme on Chemical Safety: Evaluation of Antidotes)

Antidotes for Poisoning by Cyanide: (Series Number 2 International Programme on Chemical Safety: Evaluation of Antidotes)


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About the Book

This, the second volume in the series, compares the efficacy of and indications for the clinical and field use of various antidotes for cyanide poisoning. These include oxygen; sodium thiosulphate; amyl nitrate; 4-dimethylaminophenol; hydroxocobalamine; and dicobalt edetate. The volume also assesses agents used to treat methaemoglobemia. This important new series arises from a coordinated programme of the International Programme on Chemical Safety (IPCS) (ILO/UNEP/WHO) and the Commission of the European Communities (CEC) to evaluate the efficacy of and indications for clinical and field use of these antidotes and other agents to treat poisoning.

Table of Contents:
Preface; Abbreviations; Part I. Overview: 1. Historical review; 2. Potential sources of cyanide; 3. Toxicity of cyanide in man; 4. Mechanism of toxicity; 5. Clinical features; 6. Laboratory findings; 7. Biological detoxification of cyanide; 8. Protective measures for occupational exposure; 9. Treatment; 10. Summary of treatment recommendations; 11. Summary of analytical aspects; 12. Proposed areas for research; 13. New developments in cyanide antidotes; 14. References; Part II. Oxygen: 15. Introduction; 16. Name and chemical formula of antidote; 17. Physico-chemical properties of molecular oxygen; 18. Synthesis; 19. Analytical methods; 20. Storage conditions; 21. General properties; 22. Animal studies; 23. Volunteer studies of pulmonary oxygen toxicity; 24. Clinical studies of oxygen toxicity; 25. Summary of evaluation; 26. Model information sheet; 27. References; Part III. Sodium Thiosulfate: 28. Introduction; 29. Name and chemical formula of antidote; 30. Physico-chemical properties; 31. Synthesis; 32. Analytical methods; 33. Shelf-life; 34. General properties; 35. Animal studies; 36. Volunteer studies; 37. Clinical studies; 38. Clinical studies - case reports; 39. Summary of evaluation; 40. Model information sheet; 41. References; Part IV. Hydroxocobalamine: 42. Introduction; 43. Name and chemical formula of antidote; 44. Physico-chemical properties; 45. Synthesis; 46. Analytical methods; 47. Shelf-life; 48. General properties; 49. Animal studies; 50. Volunteer studies; 51. Clinical studies; 52. Clinical studies - case reports; 53. Summary of evaluation; 54. Model information sheet; 55. References; Part V. Dicobalt Edetate: 56. Introduction; 57. Name and chemical formula; 58. Physico-chemical properties; 59. Synthesis; 60. Analytical methods; 61. Stability and shelf-life; 62. General properties; 63. Animal studies; 64. Volunteer studies; 65. Clinical trials; 66. Clinical studies - case reports; 67. Summary of evaluation; 68. Model information sheet; 69. References; Part VI. Amyl Nitrate: 70. Introduction; 71. Name and chemical formula; 72. Physico-chemical properties; 73. Synthesis; 74. Analytical methods; 75. Shelf-life; 76. General properties; 77. Animal studies; 78. Volunteer studies; 79. Clinical studies; 80. Clinical studies - case reports; 81. Summary of evaluation; 82. Model information sheet; 83. References; Part VII. Sodium Nitrite: 84. Introduction; 85. Name and chemical formula; 86. Physico-chemical properties; 87. Synthesis; 88. Analytical methods; 89. Shelf-life; 90. General properties; 91. Animal studies; 92. Volunteer studies; 93. Clinical studies; 94. Clinical studies - case reports; 95. Summary of evaluation; 96. Model information sheet; 97. References; Part VIII. 4-Dimethylaminophenol: 98. Introduction; 99. Name and chemical formula; 100. Physico-chemical properties; 101. Synthesis; 102. Analytical methods; 103. Shelf-life; 104. General properties; 105. Animal studies; 106. Volunteer studies; 107. Clinical studies; 108. Clinical studies - case reports; 109. Summary of evaluation; 110. Model information sheet; Part IX. Methylene Blue and Toluidine Blue: 111. Methylene blue; 112. Toluidine Blue; Part X. Analytical Methods for Cyanide Alone and in Combination with Cyanide Antidotes in Blood: 113. Qualitative methods; 114. Microdiffusion technique; 115. References.

Review :
."..easy to find specific information. The writing is clear and easy to follow, and the information is interesting and useful....a useful and concise review of a very important topic. It will be particularly useful for many clinical pharmacologists, all clinical toxicologists and every Poison Centre." Michael A. McGuigan, Canadian Journal of Clinical Pharmacology


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Product Details
  • ISBN-13: 9780521454582
  • Publisher: Cambridge University Press
  • Publisher Imprint: Cambridge University Press
  • Height: 255 mm
  • No of Pages: 203
  • Returnable: N
  • Returnable: N
  • Spine Width: 15 mm
  • Width: 177 mm
  • ISBN-10: 0521454581
  • Publisher Date: 13 Jan 1994
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Returnable: N
  • Series Title: Series Number 2 International Programme on Chemical Safety: Evaluation of Antidotes
  • Weight: 535 gr


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Antidotes for Poisoning by Cyanide: (Series Number 2 International Programme on Chemical Safety: Evaluation of Antidotes)
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