Mechanics of Biomaterials: Fundamental Principles for Implant Design(Cambridge Texts in Biomedical Engineering)

Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues and presents case studies in four key clinical areas: orthopedics, cardiovascular devices, dentistry and soft tissue implants. Each chapter ends with a list of topical questions, making this an ideal course textbook for senior undergraduate and graduate students, and also a self-study tool for engineers, scientists and clinicians.

Table of Contents:
Part I. Materials: 1. Biocompatibility, sterilization and materials selection for implant design; 2. Metals for medical implants; 3. Ceramics; 4. Polymers; 5. Mechanical behavior of structural tissues; Part II. Mechanics: 6. Elasticity; 7. Viscoelasticity; 8. Failure theories; 9. Fracture mechanics; 10. Fatigue; 11. Friction, lubrication and wear; Part III. Case Studies: 12. Regulatory affairs and testing; 13. Orthopedics; 14. Cardiovascular devices; 15. Oral and maxillofacial devices; 16. Soft tissue replacements; Appendix A. Selected topics from mechanics of materials; Appendix B. Table of material properties of engineering biomaterials and tissues; Appendix C. Teaching methodologies in biomaterials; Glossary; List of symbols.

About the Author :
Lisa A. Pruitt is the Lawrence Talbot Chair of Engineering at the University of California, Berkeley and also serves as an adjunct professor in the Department of Orthopedic Surgery at the University of California, San Francisco. She recently served as the Associate Dean of Lifelong Learning and Outreach Education in the College of Engineering and has received numerous awards including the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring (2004) and the Graduate Student Instructor Mentor Award from the University of California, Berkeley (2009). Ayyana M. Chakravartula received her Ph.D. in Mechanical Engineering from the University of California, Berkeley in 2005. She currently works at Exponent, Inc. in Menlo Park, CA, in its Mechanics and Materials practice. She has worked as a research scientist at the Cambridge Polymer Group in Boston, MA, and has served as an adjunct lecturer at Boston University. She has mentored numerous students, interns and research assistants in her graduate and postgraduate career.

Review :
'Mechanics of Biomaterials is the textbook I have been waiting for. This comprehensive work synthesizes the science and engineering of biomaterials that has developed over the past three decades into a highly useful textbook for training students … as I reviewed this work it felt like I was reviewing my own lecture notes developed over 20 years. [It] combines materials science, mechanics and medical device design and analysis in a seamless and thorough manner incorporating many critical studies from the literature into a clear and comprehensive work … Pruitt and Chakravartula have succeeded in developing an outstanding text and reference book that should be required reading for all who aspire to design, develop and evaluate medical devices.' Jeremy L. Gilbert, Syracuse University '… a detailed yet easy-to-read book that can be used by materials scientists and biomedical engineers, from both the budding biomedical engineering student to the seasoned medical device designer. It combines the fundamentals of plastics, metals, and ceramics behavior with the required properties for the often challenging loading and environmental conditions found in the body. I particularly liked Pruitt and Chakravartula's technique of introducing a detailed discussion of the theoretical explanation of a particular material class's response to a loading environment, and then providing a real-life case study demonstrating how the theoretical response translates to clinical performance … The book is rich in practical examples of biomaterials used in permanent implants currently on the market. Sufficient historical information is provided on implant successes and failures to appreciate the challenges for material and design selection in the areas of both hard and soft tissue replacement.' Stephen Spiegelberg, Cambridge Polymer Group, Inc. 'Mechanics of Biomaterials: Fundamental Principles for Implant Design provides a much needed comprehensive resource for engineers, physicians, and implant designers at every level of training and practice. The book includes a historical background which outlines the engineering basis of traditional implant designs, and interactions of materials, biology, and mechanics resulting in clinical success or failure of these devices. Each chapter contains a detailed description of the engineering principles which are critical to understand the mechanical behavior of biomaterials and implants in vivo. The scope of the text covers orthopaedics, cardiovascular devices, dental, and soft tissue implants, and should help considerably in our efforts to improve the function and durability of biomaterials and implants used in clinical practice.' Michael Ries, University of California, San Francisco